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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Climbing to the Next Step: Photosensitive Protein Labels [作者：SCHULTZ CARSTEN,期刊：ACS CHEMICAL BIOLOGY, 页码：447-448 , 文章类型： Article，,卷期：2010年5-5] The tool set for intracellular labeling has received its newest addition. It is now possible to attach a fluorescent molecule to proteins inside living cells and to change the fluorescent properties at some point in time... Modulating the Bioluminescence Emission of Photoproteins by in Vivo Site-Directed Incorporation of Non-Natural Amino Acids [作者：ROWE LAURA; ENSOR MARK; MEHL RYAN; DAUNERT SYLVIA,期刊：ACS CHEMICAL BIOLOGY, 页码：455-460 , 文章类型： Article，,卷期：2010年5-5] The in vivo incorporation of non-natural amino acids into specific sites within proteins has become an extremely powerful tool for bio- and protein chemists in recent years. One avenue that has yet to be explored, howeve... Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-beta-Hexosaminidase Inhibitors [作者：HO CHINGWEN; POPAT SHINDE D; LIU TAWEI; TSAI KENGCHANG; HO MENGJUNG; CHEN WEIHUNG; YANG ANSUEI; LIN CHUNHUNG,期刊：ACS CHEMICAL BIOLOGY, 页码：489-497 , 文章类型： Article，,卷期：2010年5-5] Human N-acetyl-beta-hexosaminidase (Hex) isozymes are considered to be important targets for drug discovery. They are directly linked to osteoarthritis because Hex is the predominant glycosidase released by chondrocytes ... Isozyme-Specific Fluorescent Inhibitor of Glutathione S-Transferase Omega 1 [作者：SON JUNGHYUN; LEE JAEJUNG; LEE JUNSEOK; SCHUELLER ANDREAS; CHANG YOUNGTAE,期刊：ACS CHEMICAL BIOLOGY, 页码：449-453 , 文章类型： Article，,卷期：2010年5-5] Recently, the glutathione S-transferase omega 1 (GSTO1) is suspected to be involved in certain cancers and neurodegenerative diseases. However, profound investigation on the pathological roles of GSTO1 has been hampered ... Photoactivatable and Photoconvertible Fluorescent Probes for Protein Labeling [作者：MAUREL DAMIEN; BANALA SAMBASHIVA; LAROCHE THIERRY; JOHNSSON KAI,期刊：ACS CHEMICAL BIOLOGY, 页码：507-516 , 文章类型： Article，,卷期：2010年5-5] Photosensitive probes are powerful tools to study cellular processes with high temporal and spatial resolution. However, most synthetic fluorophores suited for biomolecular imaging have not been converted yet to appropri... ACS Publications on the Go [作者：MARTENS ERIC,期刊：ACS CHEMICAL BIOLOGY, 页码：437-437 , 文章类型： Editorial Material，,卷期：2010年5-5] no Asymmetric Allosteric Signaling in Aspartate Transcarbamoylase [作者：MENDES KIMBERLY R; MARTINEZ JESSICA A; KANTROWITZ EVAN R,期刊：ACS CHEMICAL BIOLOGY, 页码：499-506 , 文章类型： Article，,卷期：2010年5-5] Here we use the fluorescence from a genetically encoded unnatural amino acid, L-(7-hydroxycoumarin-4-yl)ethylglycine (HCE-Gly), replacing an amino acid in the regulatory site of Escherichia coil aspartate transcarbamoyla... Targeted Delivery of Antigen Processing Inhibitors to Antigen Presenting Cells via Mannose Receptors [作者：RAIBER EUNANG; TULONE CALOGERO; ZHANG YANJING; MARTINEZPOMARES LUISA; STEED EMILY; SPONAAS ANNA M; LANGHORNE JEAN; NOURSADEGHI MANDAD; CHAIN BENJAMIN M; TABOR ALETHEA B,期刊：ACS CHEMICAL BIOLOGY, 页码：461-476 , 文章类型： Article，,卷期：2010年5-5] Improved chemical inhibitors are required to dissect the role of specific antigen processing enzymes and to complement genetic models. In this study we explore the in vitro and in vivo properties of a novel class of targ... Rescue of Glaucoma-Causing Mutant Myocilin Thermal Stability by Chemical Chaperones [作者：BURNS J NICOLE; ORWIG SUSAN D; HARRIS JULIA L; WATKINS J DERRICK; VOLLRATH DOUGLAS; LIEBERMAN RAQUEL L,期刊：ACS CHEMICAL BIOLOGY, 页码：477-487 , 文章类型： Article，,卷期：2010年5-5] Mutations in myocilin cause an inherited form of open angle glaucoma, a prevalent neurodegenerative disorder associated with increased intraocular pressure. Myocilin forms part of the trabecular meshwork extracellular ma... X-ray Structures of Isopentenyl Phosphate Kinase [作者：MABANGLO MARK F; SCHUBERT HEIDI L; CHEN MO; HILL CHRISTOPHER P; POULTER C DALE,期刊：ACS CHEMICAL BIOLOGY, 页码：517-527 , 文章类型： Article，,卷期：2010年5-5] Isoprenoid compounds are ubiquitous in nature, participating in important biological phenomena such as signal transduction, aerobic cellular respiration, photosynthesis, insect communication, and many others. They are de...