- Structural Analysis of the Smad2-MAN1 Interaction That Regulates Transforming Growth Factor-beta Signaling at the Inner Nuclear Membrane
[作者:Konde, E; Bourgeois, B; Tellier-Lebegue, C; Wu, W; Perez, J; Caputo, S; Attanda, W; Gasparini, S; Charbonnier, JB; Gilquin, B; Worman, HJ; Zinn-Justin, S,期刊:Biochemistry, 页码:8020-8032 , 文章类型: Article,,卷期:2010年49-37]
- MAN1, an integral protein of the inner nuclear membrane, influences transforming growth factor-beta (TGF-beta) signaling by directly interacting with R-Smads. Heterozygous loss of function mutations in the gene encoding ...
- Backbone Amide Dynamics Studies of Apo-L75F-TrpR, a Temperature-Sensitive Mutant of the Tryptophan Repressor Protein (TrpR): Comparison with the N-15 NMR Relaxation Profiles of Wild-Type and A77V Mutant Apo-TrpR Repressors
[作者:Goel, A; Tripet, BP; Tyler, RC; Nebert, LD; Copie, V,期刊:Biochemistry, 页码:8006-8019 , 文章类型: Article,,卷期:2010年49-37]
- Backbone amide dynamics studies were conducted on a temperature-sensitive mutant (L75F-TrpR) of the tryptophan repressor protein (TrpR) of Escherichia coli in its apo (i.e., no L-tryptophan corepressor-bound) form. The N...
- Distinct Extracytoplasmic Siderophore Binding Proteins Recognize Ferrioxamines and Ferricoelichelin in Streptomyces coelicolor A3(2)
[作者:Patel, P; Song, LJ; Challis, GL,期刊:Biochemistry, 页码:8033-8042 , 文章类型: Article,,卷期:2010年49-37]
- Under iron limitation, the Gram-positive bacterium Streptomyces coelicolor A3(2) excretes three siderophores of the hydroxamate type: desferrioxamine B, desferrioxamine E, and coelichelin. These sequester iron from insol...
- Dual-Color Luciferase Mouse Directly Demonstrates Coupled Expression of Two Clock Genes
[作者:Noguchi, T; Michihata, T; Nakamura, W; Takumi, T; Shimizu, R; Yamamoto, M; Ikeda, M; Ohmiya, Y; Nakajima, Y,期刊:Biochemistry, 页码:8053-8061 , 文章类型: Article,,卷期:2010年49-37]
- We have established a dual-color transgenic mouse that simultaneously reports the expression of two clock genes, Bmal1 and Per2, in a single tissue. The expression of the two genes is monitored with green- and red-emitti...
- Characterization of Glycosyltransferase DesVII and Its Auxiliary Partner Protein DesVIII in the Methymycin/Pikromycin Biosynthetic Pathway
[作者:Borisova, SA; Liu, HW,期刊:Biochemistry, 页码:8071-8084 , 文章类型: Article,,卷期:2010年49-37]
- The in vitro characterization of the catalytic activity of DesVII, the glycosyltransferase involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin in Streptomyces v...
- Bronsted Analysis and Rate-Limiting Steps for the T5 Flap Endonuclease Catalyzed Hydrolysis of Exonucleolytic Substrates
[作者:Sengerova, B; Tomlinson, C; Atack, JM; Williams, R; Sayers, JR; Williams, NH; Grasby, JA,期刊:Biochemistry, 页码:8085-8093 , 文章类型: Article,,卷期:2010年49-37]
- During replication and repair flap endonucleases (FENs) catalyze endonucleolytic and exonucleolytic (EXO) DNA hydrolyses. Altering the leaving group pK(a), by replacing the departing nucleoside with analogues, had minima...
- The Flavanol (-)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity
[作者:Meng, FL; Abedini, A; Plesner, A; Verchere, CB; Raleigh, DP,期刊:Biochemistry, 页码:8127-8133 , 文章类型: Article,,卷期:2010年49-37]
- Islet amyloid polypeptide (IAPP, amylin) is the major protein component of the islet amyloid deposits associated with type 2 diabetes. The polypeptide lacks a well-defined structure in its monomeric state but readily ass...
- Redox Reactions of the alpha-Synuclein-Cu2+ Complex and Their Effects on Neuronal Cell Viability
[作者:Wang, CS; Liu, L; Zhang, L; Peng, Y; Zhou, FM,期刊:Biochemistry, 页码:8134-8142 , 文章类型: Article,,卷期:2010年49-37]
- alpha-Synuclein (alpha-syn), a presynaptic protein believed to play an important role in neuropathology in Parkinson's disease (PD), is known to bind Cu2+. Cu2+ has been shown to accelerate the aggregation of alpha-syn t...
- Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA
[作者:Karalewitz, APA; Kroken, AR; Fu, ZJ; Baldwin, MR; Kim, JJP; Barbieri, JT,期刊:Biochemistry, 页码:8117-8126 , 文章类型: Article,,卷期:2010年49-37]
- The botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. There are seven serotypes of BoNTs (A-G) based on a lack of cross antiserum neutralization. BoNTs utilize gangliosides as components of the...
- Interaction Kinetic and Structural Dynamic Analysis of Ligand Binding to Acetylcholine-Binding Protein
[作者:Geitmann, M; Retra, K; de Kloe, GE; Homan, E; Smit, AB; de Esch, IJP; Danielson, UH,期刊:Biochemistry, 页码:8143-8154 , 文章类型: Article,,卷期:2010年49-37]
- The mechanism of agonist interactions with Cys-loop ligand-gated ion channels has been studied using the acetylcholine-binding protein (AChBP) from Lymnaea stagnalis as a model protein and acetylcholine, nicotine, epibat...
- Kinetic Analysis of 14-3-3-Inhibited Arabidopsis thaliana Nitrate Reductase
[作者:Lambeck, I; Chi, JC; Krizowski, S; Mueller, S; Mehlmer, N; Teige, M; Fischer, K; Schwarz, G,期刊:Biochemistry, 页码:8177-8186 , 文章类型: Article,,卷期:2010年49-37]
- Eukaryotic assimilatory nitrate reductase (NR) is a dimeric multidomain molybdo-heme-flavo protein that catalyzes the first and rate-limiting step in the nitrate assimilation of plants, algae, and fungi. Nitrate reductio...
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