- Rat Carboxylesterase ES-4 Enzyme Functions as a Major Hepatic Neutral Cholesteryl Ester Hydrolase
[作者:Parathath, S; Dogan, S; Joaquin, VA; Ghosh, S; Guo, L; Weibel, GL; Rothblat, GH; Harrison, EH; Fisher, EA,期刊:Journal of Biological Chemistry, 页码:39683-39692 , 文章类型: Article,,卷期:2011年286-46]
- Although esterification of free cholesterol to cholesteryl ester in the liver is known to be catalyzed by the enzyme acyl-coenzyme A: cholesterol acyltransferase, ACAT, the neutral cholesteryl ester hydrolase (nCEH) that...
- The Cancer-associated K351N Mutation Affects the Ubiquitination and the Translocation to Mitochondria of p53 Protein
[作者:Muscolini, M; Montagni, E; Palermo, V; Di Agostino, S; Gu, W; Abdelmoula-Souissi, S; Mazzoni, C; Blandino, G; Tuosto, L,期刊:Journal of Biological Chemistry, 页码:39693-39702 , 文章类型: Article,,卷期:2011年286-46]
- Stress-induced monoubiquitination of p53 is a crucial event for the nuclear-cytoplasm-mitochondria trafficking and transcription-independent pro-apoptotic functions of p53. Although an intact ubiquitination pathway and a...
- MYC Protein Inhibits Transcription of the MicroRNA Cluster MC-let-7a-1 similar to let-7d via Noncanonical E-box
[作者:Wang, ZF; Lin, S; Li, JLJ; Xu, ZH; Yao, H; Zhu, X; Xie, D; Shen, Z; Sze, J; Li, K; Lu, G; Chan, DTM; Poon, WS; Kung, HF; Lin, MCM,期刊:Journal of Biological Chemistry, 页码:39703-39714 , 文章类型: Article,,卷期:2011年286-46]
- The human microRNA cluster MC-let-7a-1 similar to let-7d, with three members let-7a-1, let-7f-1, and let-7d, is an important cluster of the let-7 family. These microRNAs play critical roles in regulating development and ...
- A(1)A(o)-ATP Synthase of Methanobrevibacter ruminantium Couples Sodium Ions for ATP Synthesis under Physiological Conditions
[作者:McMillan, DGG; Ferguson, SA; Dey, D; Schroder, K; Aung, HL; Carbone, V; Attwood, GT; Ronimus, RS; Meier, T; Janssen, PH; Cook, GM,期刊:Journal of Biological Chemistry, 页码:39882-39892 , 文章类型: Article,,卷期:2011年286-46]
- An unresolved question in the bioenergetics of methanogenic archaea is how the generation of proton-motive and sodium-motive forces during methane production is used to synthesize ATP by the membrane-bound A(1)A(o)-ATP s...
- A Complex of Nuclear Factor I-X3 and STAT3 Regulates Astrocyte and Glioma Migration through the Secreted Glycoprotein YKL-40
[作者:Singh, SK; Bhardwaj, R; Wilczynska, KM; Dumur, CI; Kordula, T,期刊:Journal of Biological Chemistry, 页码:39893-39903 , 文章类型: Article,,卷期:2011年286-46]
- Nuclear factor I-X3 (NFI-X3) is a newly identified splice variant of NFI-X that regulates expression of several astrocyte-specific markers, such as glial fibrillary acidic protein. Here, we identified a set of genes regu...
- Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor
[作者:Proto, WR; Castanys-Munoz, E; Black, A; Tetley, L; Moss, CX; Juliano, L; Coombs, GH; Mottram, JC,期刊:Journal of Biological Chemistry, 页码:39914-39925 , 文章类型: Article,,卷期:2011年286-46]
- Metacaspases are caspase family cysteine peptidases found in plants, fungi, and protozoa but not mammals. Trypanosoma brucei is unusual in having five metacaspases (MCA1-MCA5), of which MCA1 and MCA4 have active site sub...
- Vascular Endothelial Growth Factor Receptor 2 Direct Interaction with Nephrin Links VEGF-A Signals to Actin in Kidney Podocytes
[作者:Bertuccio, C; Veron, D; Aggarwal, PK; Holzman, L; Tufro, A,期刊:Journal of Biological Chemistry, 页码:39933-39944 , 文章类型: Article,,卷期:2011年286-46]
- The transmembrane protein nephrin is an essential component of slit diaphragms, the specialized cell junctions that link podocyte foot processes. Podocytes are epithelial cells that surround the glomerular capillaries in...
- Protein Phosphatase 2A (PP2A)-specific Ubiquitin Ligase MID1 Is a Sequence-dependent Regulator of Translation Efficiency Controlling 3-Phosphoinositide-dependent Protein Kinase-1 (PDPK-1)
[作者:Aranda-Orgilles, B; Rutschow, D; Zeller, R; Karagiannidis, AI; Kohler, A; Chen, CW; Wilson, T; Krause, S; Roepcke, S; Lilley, D; Schneider, R; Schweiger, S,期刊:Journal of Biological Chemistry, 页码:39945-39957 , 文章类型: Article,,卷期:2011年286-46]
- We have shown previously that the ubiquitin ligase MID1, mutations of which cause the midline malformation Opitz BBB/G syndrome (OS), serves as scaffold for a microtubule-associated protein complex that regulates protein...
- Molecular Characterization of the MicroRNA-138-Fos-like Antigen 1 (FOSL1) Regulatory Module in Squamous Cell Carcinoma
[作者:Jin, Y; Wang, C; Liu, XQ; Mu, WB; Chen, ZJ; Yu, DS; Wang, AX; Dai, Y; Zhou, XF,期刊:Journal of Biological Chemistry, 页码:40104-40109 , 文章类型: Article,,卷期:2011年286-46]
- MicroRNA-138 is one of the most frequently down-regulated microRNAs in cancer. We recently identified 51 candidate targets of microRNA-138 (Jiang, L., Dai, Y., Liu, X., Wang, C., Wang, A., Chen, Z., Heidbreder, C. E., Ko...
- Extracellular Superoxide Dismutase in Insects CHARACTERIZATION, FUNCTION, AND INTERSPECIFIC VARIATION IN PARASITOID WASP VENOM
[作者:Colinet, D; Cazes, D; Belghazi, M; Gatti, JL; Poirie, M,期刊:Journal of Biological Chemistry, 页码:40110-40121 , 文章类型: Article,,卷期:2011年286-46]
- Endoparasitoid wasps inject venom proteins with their eggs to protect them from the host immune response and ensure successful parasitism. Here we report identification of Cu,Zn superoxide dismutase (SOD) transcripts for...
- A Systematic Study of Site-specific GalNAc-type O-Glycosylation Modulating Proprotein Convertase Processing
[作者:Schjoldager, KTBG; Vester-Christensen, MB; Goth, CK; Petersen, TN; Brunak, S; Bennett, EP; Levery, SB; Clausen, H,期刊:Journal of Biological Chemistry, 页码:40122-40132 , 文章类型: Article,,卷期:2011年286-46]
- Site-specific GalNAc-type O-glycosylation is emerging as an important co-regulator of proprotein convertase (PC) processing of proteins. PC processing is crucial in regulating many fundamental biological pathways and O-g...
- N-Acetylglucosamine Inhibits T-helper 1 (Th1)/T-helper 17 (Th17) Cell Responses and Treats Experimental Autoimmune Encephalomyelitis
[作者:Grigorian, A; Araujo, L; Naidu, NN; Place, DJ; Choudhury, B; Demetriou, M,期刊:Journal of Biological Chemistry, 页码:40133-40141 , 文章类型: Article,,卷期:2011年286-46]
- Current treatments and emerging oral therapies for multiple sclerosis (MS) are limited by effectiveness, cost, and/or toxicity. Genetic and environmental factors that alter the branching of Asn (N)-linked glycans result ...
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