- Brain-derived Neurotrophic Factor (BDNF) Enhances GABA Transport by Modulating the Trafficking of GABA Transporter-1 (GAT-1) from the Plasma Membrane of Rat Cortical Astrocytes
[作者:Vaz, SH; Jorgensen, TN; Cristovao-Ferreira, S; Duflot, S; Ribeiro, JA; Gether, U; Sebastiao, AM,期刊:Journal of Biological Chemistry, 页码:40464-40476 , 文章类型: Article,,卷期:2011年286-47]
- The gamma-aminobutyric acid (GABA) transporters (GATs) are located in the plasma membrane of neurons and astrocytes and are responsible for termination of GABAergic transmission. It has previously been shown that brain d...
- Relative Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Tumor Necrosis Factor-alpha (TNF-alpha)-induced Lipolysis in Adipocytes
[作者:Yang, XY; Zhang, XD; Heckmann, BL; Lu, X; Liu, J,期刊:Journal of Biological Chemistry, 页码:40477-40485 , 文章类型: Article,,卷期:2011年286-47]
- TNF-alpha potently stimulates basal lipolysis in adipocytes, which may contribute to hyperlipidemia and peripheral insulin resistance in obesity. Recent studies show that adipose triglyceride lipase (ATGL) and hormone-se...
- Ordered Assembly of Heat Shock Proteins, Hsp26, Hsp70 Hsp90, and Hsp104, on Expanded Polyglutamine Fragments Revealed by Chemical Probes
[作者:Walter, GM; Snnith, MC; Wisen, S; Basrur, V; Elenitoba-Johnson, KSJ; Duennwald, ML; Kumar, A; Gestwicki, JE,期刊:Journal of Biological Chemistry, 页码:40486-40493 , 文章类型: Article,,卷期:2011年286-47]
- In Saccharomyces cerevisae, expanded polyglutamine (polyQ) fragments are assembled into discrete cytosolic aggregates in a process regulated by the molecular chaperones Hsp26, Hsp70, Hsp90, and Hsp104. To better understa...
- PEX5 Protein Binds Monomeric Catalase Blocking Its Tetrarnerization and Releases It upon Binding the N-terminal Domain of PEX14
[作者:Freitas, MO; Francisco, T; Rodrigues, TA; Alencastre, IS; Pinto, MP; Grou, CP; Carvalho, AF; Fransen, M; Sa-Miranda, C; Azevedo, JE,期刊:Journal of Biological Chemistry, 页码:40509-40519 , 文章类型: Article,,卷期:2011年286-47]
- Newly synthesized peroxisomal matrix proteins are targeted to the organelle by PEX5. PEX5 has a dual role in this process. First, it acts as a soluble receptor recognizing these proteins in the cytosol. Subsequently, at ...
- The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor beta (TGF-beta) Signaling and the Development of Regulatory T Cells
[作者:Zhao, YG; Thornton, AM; Kinney, MC; Ma, CA; Spinner, JJ; Fuss, IJ; Shevach, EM; Jain, A,期刊:Journal of Biological Chemistry, 页码:40520-40530 , 文章类型: Article,,卷期:2011年286-47]
- CYLD is a lysine 63-deubiquitinating enzyme that inhibits NF-kappa B and JNK signaling. Here, we show that CYLD knock-out mice have markedly increased numbers of regulatory T cells (Tregs) in peripheral lymphoid organs b...
- Jumonji/ARID1 B (JARID1B) Protein Promotes Breast Tumor Cell Cycle Progression through Epigenetic Repression of MicroRNA let-7e
[作者:Mitra, D; Das, PM; Huynh, FC; Jones, FE,期刊:Journal of Biological Chemistry, 页码:40531-40535 , 文章类型: Article,,卷期:2011年286-47]
- MicroRNAs (miRs) function as tumor suppressors or oncogenes in multiple tumor types. Although miR expression is tightly regulated, the molecular basis of miR regulation is poorly understood. Here, we investigated the inf...
- The CD24 Protein Inducible Expression System Is an Ideal Tool to Explore the Potential of CD24 as an Oncogene and a Target for Immunotherapy in Vitro and in Vivo
[作者:Shapira, S; Kazanov, D; Weisblatt, S; Starr, A; Arber, N; Kraus, S,期刊:Journal of Biological Chemistry, 页码:40548-40555 , 文章类型: Article,,卷期:2011年286-47]
- CD24 is a cell surface, heavily glycosylated glycosylphosphatidylinositol-anchored mucin-like protein that is overexpressed in various human malignancies. To accurately analyze CD24 function and dissect its biological ro...
- Interactions of a Replication Initiator with Histone H1-like Proteins Remodel the Condensed Mitochondrial Genome
[作者:Kapeller, K; Milman, N; Yaffe, N; Shlomai, J,期刊:Journal of Biological Chemistry, 页码:40566-40574 , 文章类型: Article,,卷期:2011年286-47]
- Kinetoplast DNA (kDNA), the mitochondrial genome of trypanosomatids, consists of several thousand topologically interlocked DNA circles. Mitochondrial histone H1-like proteins were implicated in the condensation of kDNA ...
- Fibroblast Growth Factor 2 Stimulation of Osteoblast Differentiation and Bone Formation Is Mediated by Modulation of the Wnt Signaling Pathway
[作者:Fei, YR; Xiao, LP; Doetschman, T; Coffin, DJ; Hurley, MM,期刊:Journal of Biological Chemistry, 页码:40575-40583 , 文章类型: Article,,卷期:2011年286-47]
- Fibroblast growth factor 2 (FGT2) positively modulates osteoblast differentiation and bone formation. However, the mechanism(s) is not fully understood. Because the Wnt canonical pathway is important for bone homeostasis...
- Inhibition of Gluconeogenic Genes by Calcium-regulated Heat-stable Protein 1 via Repression of Peroxisome Proliferator-activated Receptor alpha
[作者:Fan, YB; Guo, YH; Hamblin, M; Chang, L; Zhang, JF; Chen, YE,期刊:Journal of Biological Chemistry, 页码:40584-40594 , 文章类型: Article,,卷期:2011年286-47]
- Gluconeogenesis contributes to insulin resistance in type 1 and type 2 diabetes, but its regulation and the underlying molecular mechanisms remain unclear. Recently, calcium-regulated heat-stable protein 1 (CARHSP1) was ...
- Crystal Structure of Fc gamma Receptor I and Its Implication in High Affinity gamma-Immunoglobulin Binding
[作者:Lu, JH; Ellsworth, JL; Hamacher, N; Oak, SW; Sun, PD,期刊:Journal of Biological Chemistry, 页码:40608-40613 , 文章类型: Article,,卷期:2011年286-47]
- Fc gamma receptors (Fc gamma Rs) play critical roles in humoral and cellular immune responses through interactions with the Fc region of immunoglobulin G (IgG). Among them, Fc gamma RI is the only high affinity receptor ...
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