- Epstein-Barr Virus Coinfection in Cerebrospinal Fluid Is Associated With Increased Mortality in Malawian Adults With Bacterial Meningitis
[作者:Kelly, MJ; Benjamin, LA; Cartwright, K; Ajdukiewicz, KMB; Cohen, DB; Menyere, M; Galbraith, S; Guiver, M; Neuhann, F; Solomon, T; Lalloo, DG; Heyderman, RS,期刊:Journal of Infectious Diseases, 页码:106-110 , 文章类型: Article,,卷期:2012年205-1]
- Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, E...
- Molecular Determinants of HIV-2 R5-X4 Tropism in the V3 Loop: Development of a New Genotypic Tool
[作者:Visseaux, B; Hurtado-Nedelec, M; Charpentier, C; Collin, G; Storto, A; Matheron, S; Larrouy, L; Damond, F; Brun-Vezinet, F; Descamps, D,期刊:Journal of Infectious Diseases, 页码:111-120 , 文章类型: Article,,卷期:2012年205-1]
- Objective. The use of CCR5 inhibitors requires a tool to predict human immunodeficiency virus type 2 (HIV-2) tropism, as established in HIV-1. The aim of our study was to identify genotypic determinants of HIV-2 tropism ...
- Vaccination With Parenteral Toxoid B Protects Hamsters Against Lethal Challenge With Toxin A-Negative, Toxin B-Positive Clostridium difficile but Does Not Prevent Colonization
[作者:Siddiqui, F; O'Connor, JR; Nagaro, K; Cheknis, A; Sambol, SP; Vedantam, G; Gerding, DN; Johnson, S,期刊:Journal of Infectious Diseases, 页码:128-133 , 文章类型: Article,,卷期:2012年205-1]
- Toxin A has historically been regarded as the primary virulence determinant in Clostridium difficile infection, but naturally occurring toxin A-negative, toxin B-positive (A-/B+) C. difficile strains are known to be viru...
- Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study
[作者:Vandermeer, ML; Thomas, AR; Kamimoto, L; Reingold, A; Gershman, K; Meek, J; Farley, MM; Ryan, P; Lynfield, R; Baumbach, J; Schaffner, W; Bennett, N; Zansky, S,期刊:Journal of Infectious Diseases, 页码:13-19 , 文章类型: Article,,卷期:2012年205-1]
- Background. Statins may have anti-inflammatory and immunomodulatory effects that could reduce the risk of mortality from influenza virus infections. Methods. The Centers for Disease Control and Prevention's Emerging Infe...
- Early Systemic Bacterial Dissemination and a Rapid Innate Immune Response Characterize Genetic Resistance to Plague of SEG Mice
[作者:Demeure, CE; Blanchet, C; Fitting, C; Fayolle, C; Khun, H; Szatanik, M; Milon, G; Panthier, JJ; Jaubert, J; Montagutelli, X; Huerre, M; Cavaillon, JM; Carniel, E,期刊:Journal of Infectious Diseases, 页码:134-143 , 文章类型: Article,,卷期:2012年205-1]
- Background. Although laboratory mice are usually highly susceptible to Yersinia pestis, we recently identified a mouse strain (SEG) that exhibited an exceptional capacity to resist bubonic plague and used it to identify ...
- Induction of Serine Protease Inhibitor 9 by Mycobacterium tuberculosis Inhibits Apoptosis and Promotes Survival of Infected Macrophages
[作者:Toossi, Z; Wu, MD; Rojas, R; Kalsdorf, B; Aung, H; Hirsch, CS; Walrath, J; Wolbink, A; van Ham, M; Silver, RF,期刊:Journal of Infectious Diseases, 页码:144-151 , 文章类型: Article,,卷期:2012年205-1]
- Our recent microarray analysis of infected human alveolar macrophages (AMs) found serine protease inhibitor 9 (PI-9) to be the most prominently expressed of a cluster of apoptosis-associated genes induced by virulent Myc...
- Opposing Biological Functions of Tryptophan Catabolizing Enzymes During Intracellular Infection
[作者:Divanovic, S; Sawtell, NM; Trompette, A; Warning, JI; Dias, A; Cooper, AM; Yap, GS; Arditi, M; Shimada, K; DuHadaway, JB; Prendergast, GC; Basaraba, RJ; Mellor, AL; Munn, DH; Aliberti, J; Karp, CL,期刊:Journal of Infectious Diseases, 页码:152-161 , 文章类型: Article,,卷期:2012年205-1]
- Recent studies have underscored physiological and pathophysiological roles for the tryptophan-degrading enzyme indolamine 2,3-dioxygenase (IDO) in immune counterregulation. However, IDO was first recognized as an antimic...
- Identification of H5N1-Specific T-Cell Responses in a High-risk Cohort in Vietnam Indicates the Existence of Potential Asymptomatic Infections
[作者:Powell, TJ; Fox, A; Peng, YC; Le, TQM; Lien, VTK; Hang, NLK; Wang, LL; Lee, LYH; Simmons, CP; McMichael, AJ; Farrar, JJ; Askonas, BA; Duong, TN; Thai, PQ; Nguyen, TTY; Rowland-Jones, SL; Hien, NT; Horby, P; Dong, T,期刊:Journal of Infectious Diseases, 页码:20-27 , 文章类型: Article,,卷期:2012年205-1]
- Background. Most reported human H5N1 viral infections have been severe and were detected after hospital admission. A case ascertainment bias may therefore exist, with mild cases or asymptomatic infections going undetecte...
- A Vero Cell-Derived Whole-Virus H5N1 Vaccine Effectively Induces Neuraminidase-Inhibiting Antibodies
[作者:Fritz, R; Sabarth, N; Kiermayr, S; Hohenadl, C; Howard, MK; Ilk, R; Kistner, O; Ehrlich, HJ; Barrett, PN; Kreil, TR,期刊:Journal of Infectious Diseases, 页码:28-34 , 文章类型: Article,,卷期:2012年205-1]
- A Vero cell-derived whole-virus H5N1 influenza vaccine has been shown to induce neutralizing antibodies directed against the hemagglutinin (HA) protein of diverse H5N1 strains in animal studies and clinical trials. Howev...
- Use of a Human Influenza Challenge Model to Assess Person-to-Person Transmission: Proof-of-Concept Study
[作者:Killingley, B; Enstone, JE; Greatorex, J; Gilbert, AS; Lambkin-Williams, R; Cauchemez, S; Katz, JM; Booy, R; Hayward, A; Oxford, J; Bridges, CB; Ferguson, NM; Van-Tam, JSN,期刊:Journal of Infectious Diseases, 页码:35-43 , 文章类型: Article,,卷期:2012年205-1]
- Background. Influenza transmission in humans remains poorly understood. In particular, the relative contribution of contact, large droplet, and aerosol transmission is unknown. The aims of this proof-of-concept study wer...
- Mannose-Binding Lectin Contributes to Deleterious Inflammatory Response in Pandemic H1N1 and Avian H9N2 Infection
[作者:Ling, MT; Tu, WW; Han, Y; Mao, HW; Chong, WP; Guan, J; Liu, M; Lam, KT; Law, HKW; Peiris, JSM; Takahashi, K; Lau, YL,期刊:Journal of Infectious Diseases, 页码:44-53 , 文章类型: Article,,卷期:2012年205-1]
- Background. Mannose-binding lectin (MBL) is a pattern-recognition molecule, which functions as a first line of host defense. Pandemic H1N1 (pdmH1N1) influenza A virus caused massive infection in 2009 and currently circul...
- Serum Hepatitis B Virus-DNA Levels Correlate With Long-term Adverse Outcomes in Spontaneous Hepatitis B e Antigen Seroconverters
[作者:Tseng, TC; Liu, CJ; Chen, CL; Wang, CC; Su, TH; Kuo, SFT; Chen, PJ; Chen, DS; Kao, JH,期刊:Journal of Infectious Diseases, 页码:54-63 , 文章类型: Article,,卷期:2012年205-1]
- Background. Hepatitis B e antigen (HBeAg) status and serum hepatitis B virus (HBV) DNA levels are major factors affecting the prognosis of adult HBV carriers; however, the impact of viral load on long-term outcomes after...
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