- Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway
[作者：Ferdaoussi, M; Abdelli, S; Yang, JY; Cornu, M; Niederhauser, G; Favre, D; Widmann, C; Regazzi, R; Thorens, B; Waeber, G; Abderrahmani, A,期刊：Diabetes, 页码：1205-1215 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-The pro-inflammatory cytokine interleukin-1 beta (1L-1 beta) generates pancreatic beta-cells apoptosis mainly through activation of the c-Jun NH2-terminal kinase (JNK) pathway. This study was designed to invest...
- STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3 beta
[作者：Moh, A; Zhang, WJ; Yu, S; Wang, J; Xu, XM; Li, JL; Fu, XY,期刊：Diabetes, 页码：1227-1235 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Glucose homeostasis is achieved by triggering regulation of glycogen synthesis genes in response to insulin when mammals feed, but the underlying molecular mechanism remains largely unknown. The aim of our stud...
- Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways
[作者：Dogusan, Z; Garcia, M; Flamez, D; Alexopouiou, L; Goldman, M; Gysemans, C; Mathieu, C; Libert, C; Eizirik, DL; Rasschaert, J,期刊：Diabetes, 页码：1236-1245 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Viral infections contribute to the pathogenesis of type 1 diabetes. Viruses, or viral products such as double-stranded RNA (dsRNA), affect pancreatic beta-cell survival and trigger autoimmunity by unknown mecha...
- The frequency and immunodominance of islet-specific CD8(+) T-cell responses change after type 1 diabetes diagnosis and treatment
[作者：Martinuzzi, E; Novelli, G; SCotto, M; Blancou, P; Bach, JM; Chaillous, L; Bruno, G; Chatenoud, L; van Endert, P; Mallone, R,期刊：Diabetes, 页码：1312-1320 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-ilslet-reactive CD8(+) T-cells play a key role in the pathogenesis of type 1 diabetes in the NOD mouse. The predominant T-cell specificities change over time, but whether similar shifts also occur after clinica...
- On the pathogenicity of autoantigen-specific T-cell receptors
[作者：Burton, AR; Vincent, E; Arnold, PY; Lennon, GP; Smeltzer, M; Li, CS; Haskins, K; Hutton, J; Tisch, RM; Sercarz, EE; Santamaria, P; Workman, CJ; Vignalil, DAA,期刊：Diabetes, 页码：1321-1330 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Type 1 diabetes is mediated by T-cell entry into pancreatic islets and destruction of insulin-producing beta-cells. The relative contribution of T-cells specific for different autoantigens is largely unknown be...
- Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
[作者：Zhang, X; Yeung, DCY; Karpisek, M; Stejskal, D; Zhou, ZG; Liu, F; Wong, RLC; Chow, WS; Tso, AWK; Lam, KSL; Xu, AM,期刊：Diabetes, 页码：1246-1253 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple beneficial effects on glucose homeostasis and insulin sensitivity in animal models. This study aimed to investigate the relationship be...
- Macrophage chemoattractant protein-1 deficiency fails to restrain macrophage infiltration into adipose tissue
[作者：Kirk, EA; Sagawa, ZK; McDonald, TO; O'Brien, KD; Heinecke, JW,期刊：Diabetes, 页码：1254-1261 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Monocyte chemoattractant protein-1 (MCP-1), a CC-motif chemokine, has been proposed to play critical roles in insulin resistance and recruitment of monocytes into adipose tissue. We hypothesized that the absenc...
- The role of adipocyte insulin resistance in the pathogenesis of obesity-related elevations in endocannabinoids
[作者：D'Eon, TM; Pierce, KA; Roix, JJ; Tyler, A; Chen, H; Teixeira, SR,期刊：Diabetes, 页码：1262-1268 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Obesity is associated with an overactive endocannabinoid (EC) system. The mechanisms responsible for increased ECs in obese individuals are poorly understood. Therefore, we examined the role of adipocyte insuli...
- Visceral adiposity, not abdominal subcutaneous fat area, is associated with an increase in future insulin resistance in Japanese Americans
[作者：Hayashi, T; Boyko, EJ; McNeely, MJ; Leonetti, DL; Kahn, SE; Fujimoto, WY,期刊：Diabetes, 页码：1269-1275 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Visceral adiposity is generally considered to play a key role in the metabolic syndrome. We sought to determine whether greater visceral adiposity directly measured by computed tomography (CT) is associated wit...
- Identiffication of tyrosine phosphatase 2((256-760)) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients - The Non-Insulin Requiring Autoimmune Diabetes (NIRAD) study 2
[作者：Tiberti, C; Giordano, C; Locatelli, M; Bosi, E; Bottazzo, GF; Buzzetti, R; Cucinotta, D; Galluzzo, A; Falorni, A; Dotta, F,期刊：Diabetes, 页码：1276-1283 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADAI]) identifies subjects at high risk to develop i...
- Proapoptotic BH3-only protein bid is essential for death receptor-induced apoptosis of pancreatic beta-cells
[作者：McKenzie, MD; Carrington, EM; Kaufmann, T; Strasser, A; Huang, DCS; Kay, TWH; Allison, J; Thomas, HE,期刊：Diabetes, 页码：1284-1292 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Apoptosis of pancreatic P-cells is critical in both diabetes development and failure of islet transplantation. The role in these processes of pro- and antiapoptotic Bcl-2 family proteins, which regulate apoptos...
- COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity
[作者：Fenalti, G; Hampe, CS; Arafat, Y; Law, RHP; Banga, JP; Mackay, IR; Whisstock, JC; Buckle, AM; Rowley, MJ,期刊：Diabetes, 页码：1293-1301 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-To gain structural insights into the autoantigenic properties of GAD65 in type 1 diabetes, we analyzed experimental epitope mapping data in the context of the recently determined crystal structures of GAD65 and...
- Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance
[作者：Nair, KS; Bigelow, ML; Asmann, YW; Chow, LS; Coenen-Schimke, JM; Klaus, KA; Guo, ZK; Sreekumar, R; Irving, BA,期刊：Diabetes, 页码：1166-1175 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Type 2 diabetes has become a global epidemic, and Asian Indians have a higher susceptibility to diabetes than Europeans. We investigated whether Indians had any metabolic differences compared with Northern Euro...
- Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism
[作者：Cederroth, CR; Vinciguerra, M; Gjinovci, A; Kuhne, F; Klein, M; Cederroth, M; Caille, D; Suter, M; Neumann, D; James, RW; Doerge, DR; Wallimann, T; Meda, P; Foti, M; Rohner-Jeanrenaud, F; Vassalli, JD; Nef, S,期刊：Diabetes, 页码：1176-1185 , 文章类型： Article，,卷期：2008年57-5]
- OBJECTIVE-Emerging evidence suggests that dietary phytoestrogens can have beneficial effects on obesity and diabetes, although their mode of action is not known. Here, we investigate the mechanisms mediating the action o...
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