- Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways
[作者:Deng, JY; Hsieh, PS; Huang, JP; Lu, LS; Hung, LM,期刊:Diabetes, 页码:1814-1823 , 文章类型: Article,,卷期:2008年57-7]
- OBJECTIVE-Estradiol (E,) is known to modulate insulin sensitivity and, consequently, glucose homeostasis. Resveratrol (RSV), an agonist of estrogen receptor (ER), has exerted antihyperglycemic effects in streptozotocin-i...
- Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects - Effect of beta-adrenergic stimulation
[作者:Jocken, JWE; Roepstorff, C; Goossens, GH; van der Baan, P; van Baak, M; Saris, WHM; Kiens, B; Blaak, EE,期刊:Diabetes, 页码:1834-1841 , 文章类型: Article,,卷期:2008年57-7]
- OBJECTIVE-Increased intramuscular triacylglycerol (IMTG) storage is a characteristic of the obese insulin-resistant state. We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contr...
- Protective role of programmed death 1 ligand 1 (PD-L1) in nonobese diabetic mice - The paradox in transgenic models
[作者:Wang, CJ; Chou, FC; Chu, CH; Wu, JC; Lin, SH; Chang, DM; Sytwu, HK,期刊:Diabetes, 页码:1861-1869 , 文章类型: Article,,卷期:2008年57-7]
- OBJECTIVE-Coinhibitory signals mediated via programmed death 1 (PD-1) receptor play a critical role in downregulating immune responses and in maintaining peripheral tolerance. Programmed death 1 ligand 1 (PD-L1), the int...
- Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice
[作者:Vlad, G; D'Agati, VD; Zhang, QY; Liu, ZR; Ho, EK; Mohanakumar, T; Hardy, MA; Cortesini, R; Suciu-Foca, N,期刊:Diabetes, 页码:1878-1886 , 文章类型: Article,,卷期:2008年57-7]
- OBJECTIVE-The aim of our study was to explore the immunomodulatory activity of soluble inummoglobulin (Ig)-like transcript (ILT) 3-Fc in pancreatic islet transplantation and to determine its mechanism of action.RESEARCH ...
- Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion - A new mechanism for fat-induced impairment of beta-cell function
[作者:Kebede, M; Favaloro, J; Gunton, JE; Laybutt, DR; Shaw, M; Wong, N; Fam, BC; Aston-Mourney, K; Rantzau, C; Zulli, A; Proietto, J; Andrikopoulos, S,期刊:Diabetes, 页码:1887-1895 , 文章类型: Article,,卷期:2008年57-7]
- OBJECTIVE-Fructose-1,6-bisphosphatase (FBPase) is a gluconeogenic enzyme that is upregulated in islets or pancreatic beta-cell lines exposed to high fat. However, whether specific beta-cell upregulation of FBPase can imp...
- Effect of oral amino acids on counterregulatory responses and cognitive function during insulin-induced hypoglycemia in nondiabetic and type 1 diabetic people
[作者:Rossetti, P; Porcellati, F; Ricci, NB; Candeloro, P; Cioli, P; Nair, KS; Santeusanio, F; Bolli, GB; Fanelli, CG,期刊:Diabetes, 页码:1905-1917 , 文章类型: Article,,卷期:2008年57-7]
- OBJECTIVE-Amino acids stimulate glucagon responses to hypoglycemia and may be utilized by the brain. The aim of this study was to assess the responses to hypoglycemia in nondiabetic and type 1 diabetic subjects after ing...
- Protein engineering strategies for sustained glucagon-like peptide-1 receptor-dependent control of glucose homeostasis
[作者:Picha, KM; Cunningham, MR; Drucker, DJ; Mathur, A; Ort, T; Scully, M; Soderman, A; Spinka-Doms, T; Stojanovic-Susulic, V; Thomas, BA; O'Neil, KT,期刊:Diabetes, 页码:1926-1934 , 文章类型: Article,,卷期:2008年57-7]
- OBJECTIVE-We have developed a novel platform for display and delivery of bioactive peptides that links the biological properties of the peptide to the pharmacokinetic properties of an antibody. Peptides engineered in the...
- RAGE and modulation of ischemic injury in the diabetic myocardium
[作者:Bucciarelli, LG; Ananthakrishnan, R; Hwang, YC; Kaneko, M; Soling, F; Sell, DR; Strauch, C; Monnier, VM; Yan, SF; Schmidt, AM; Ramasamy, R,期刊:Diabetes, 页码:1941-1951 , 文章类型: Article,,卷期:2008年57-7]
- OBJECTIVE-Subjects with diabetes experience an increased risk of myocardial infarction and cardiac failure compared with nondiabetic age-matched individuals. The receptor for advanced glycation end products (RAGE) is upr...
- Blockade of alpha 4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity
[作者:Feral, CC; Neels, JG; Kummer, C; Slepak, M; Olefsky, JM; Ginsberg, MH,期刊:Diabetes, 页码:1842-1851 , 文章类型: Article,,卷期:2008年57-7]
- OBJECTIVE-Many prevalent diseases of advanced societies, such as obesity-induced type 2 diabetes, are linked to indolent mononuclear cell-dependent inflammation. We previously proposed that blockade of alpha 4 integrin s...
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