- You know what we need?
[作者：Neill, US,期刊：Journal of clinical investigation, 页码：2948-2948 , 文章类型： Editorial Material，,卷期：2011年121-8]
- I've listened to many of you moan about the current flat NIH budgets, lack of funding, and the frustration of being a scientist in the current depressed economy. Instead of complaining to only ourselves in the scientific...
- Recent advances in the molecular pathophysiology of atrial fibrillation
[作者：Wakili, R; Voigt, N; Kaab, S; Dobrev, D; Nattell, S,期刊：Journal of clinical investigation, 页码：2955-2968 , 文章类型： Article，,卷期：2011年121-8]
- Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectop...
- Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice
[作者：Bazigou, E; Lyons, OTA; Smith, A; Venn, GE; Cope, C; Brown, NA; Makinen, T,期刊：Journal of clinical investigation, 页码：2984-2992 , 文章类型： Article，,卷期：2011年121-8]
- Chronic venous disease and venous hypertension are common consequences of valve insufficiency, yet the molecular mechanisms regulating the formation and maintenance of venous valves have not been studied. Here, we provid...
- Matrix Gla protein deficiency causes arteriovenous malformations in mice
[作者：Yao, YC; Jurnabay, M; Wang, A; Bostromi, KI,期刊：Journal of clinical investigation, 页码：2993-3004 , 文章类型： Article，,卷期：2011年121-8]
- Arteriovenous malformations (AVMs) in organs, such as the lungs, intestine, and brain, are characteristic of hereditary hemorrhagic telangiectasia (HHT), a disease caused by mutations in activin-like kinase receptor 1 (A...
- Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents
[作者：Lee, B; Clarke, D; Al Ahmad, A; Kahle, M; Parham, C; Auckland, L; Shaw, C; Fidanboylu, M; Orr, AW; Ogunshola, O; Fertala, A; Thomas, SA; Bix, GJ,期刊：Journal of clinical investigation, 页码：3005-3023 , 文章类型： Article，,卷期：2011年121-8]
- Stroke is the leading cause of long-term disability and the third leading cause of death in the United States. While most research thus far has focused on acute stroke treatment and neuroprotection, the exploitation of e...
- Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets
[作者：Montane, J; Bischoff, L; Soukhatcheva, G; Dai, DL; Hardenberg, G; Levings, MK; Orban, PC; Kieffer, TJ; Tan, R; Verchere, CB,期刊：Journal of clinical investigation, 页码：3024-3028 , 文章类型： Article，,卷期：2011年121-8]
- Type 1 diabetes is characterized by destruction of insulin-producing beta cells in the pancreatic islets by effector T cells. Tregs, defined by the markers CD4 and FoxP3, regulate immune responses by suppressing effector...
- Postsymptomatic restoration of SMN rescues the disease phenotype in a mouse model of severe spinal muscular atrophy
[作者：Lutz, CM; Kariya, S; Patruni, S; Osborne, MA; Liu, D; Henderson, CE; Li, DK; Pellizzoni, L; Rojas, J; Valenzuela, DM; Murphy, AJ; Winberg, ML; Monani, UR,期刊：Journal of clinical investigation, 页码：3029-3041 , 文章类型： Article，,卷期：2011年121-8]
- Spinal muscular atrophy (SMA) is a common neuromuscular disorder in humans. In fact, it is the most frequently inherited cause of infant mortality, being the result of mutations in the survival of motor neuron 1 (SMN1) g...
- Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway
[作者：Farooq, F; Molina, FA; Hadwen, J; MacKenzie, D; Witherspoon, L; Osmond, M; Holcik, M; MacKenzie, A,期刊：Journal of clinical investigation, 页码：3042-3050 , 文章类型： Article，,卷期：2011年121-8]
- Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease that is characterized by the loss of motor neurons, resulting in progressive muscle atrophy. It is caused by the loss of functional surviv...
- Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice
[作者：Hammerschmidt, SI; Friedrichsen, M; Boelter, J; Lyszkiewicz, M; Kremmer, E; Pabst, O; Forster, R,期刊：Journal of clinical investigation, 页码：3051-3061 , 文章类型： Article，,卷期：2011年121-8]
- Diarrheal diseases represent a major health burden in developing countries. Parenteral immunization typically does not induce efficient protection against enteropathogens because it does not stimulate migration of immune...
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