- Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors
[作者:Gupta, S; Rodrigues, LM; Esteves, AP; Oliveira-Campos, AMF; Nascimento, MSJ; Nazareth, N; Cidade, H; Neves, MP; Fernandes, E; Pinto, M; Cerqueira, NMFSA; Bras, N,期刊:European Journal of Medicinal Chemistry, 页码:771-780 , 文章类型: Article,,卷期:2008年43-4]
Some pyrazolo[3,4-d]pyrimidines, structurally related with allopurinol, a well known xanthine oxidase inhibitor, clinically used in the therapy of gout, have also been reported as potent inhibitors of xanthine oxidase...
- Synthesis, antimicrobial and anti-inflammatory activities of some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing trichlorophenyl moiety
[作者:Karegoudar, P; Prasad, DJ; Ashok, M; Mahalinga, M; Poojary, B; Holla, BS,期刊:European Journal of Medicinal Chemistry, 页码:808-815 , 文章类型: Article,,卷期:2008年43-4]
The reaction of 2,3,5-trichlorobenzoic acid hydrazide with carbon disullide and potassium hydroxide followed by treatment with hydrazine hydrate afforded 3-(2,3,5-trichlorophenyl)-4-amino-1,2,4-triazole-5-thione (6). ...
- Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity
[作者:Schlapper, C; Seebacher, W; Kaiser, M; Brun, R; Saf, R; Weis, R,期刊:European Journal of Medicinal Chemistry, 页码:800-807 , 文章类型: Article,,卷期:2008年43-4]
(2SR,6RS,7RS)-4-Dialkylaminobicyclo[2.2.2]octan-2-ols and several of their esters have shown promising activity against the causative organisms for malaria and sleeping sickness. The base-catalyzed epimerization of th...
- Cyclic nucleotide phosphodiesterase type 4 inhibitors: Evaluation of pyrazolo[1,5-a]-1,3,5-triazine ring system as an adenine bioisostere
[作者:Raboisson, P; Schultz, D; Muller, C; Reimund, JM; Pinna, G; Mathieu, R; Bernard, P; Do, QT; DesJarlais, RL; Justiano, H; Lugnier, C; Bourguignon, JJ,期刊:European Journal of Medicinal Chemistry, 页码:816-829 , 文章类型: Article,,卷期:2008年43-4]
A series of 8-substituted pyrazolo[1,5-a]-1,3,5-triazines were considered as a bioisosteric replacement for the 9-substituted adenine derivatives resulting in the discovery of 8-(2-methoxybenzyl)-4-(N-methylamino)-2-n...
- Synthesis, properties and photodynamic inactivation of Escherichia coli by novel cationic fullerene C-60 derivatives
[作者:Spesia, MB; Milanesio, AE; Durantini, EN,期刊:European Journal of Medicinal Chemistry, 页码:853-861 , 文章类型: Article,,卷期:2008年43-4]
A novel N,N-dimethyl-2-(4'-N,N,N-trimethylaminophenyl)fulleropyrrolidinium iodide (DTC602+) has been synthesized by 1,3-dipolar cycloaddition using 4-(N,N-dimethylamino) benzaldehyde, N-methylglycine and fullerene C-6...
- Synthesis of novel 4,6-disubstituted quinazoline derivatives, their anti-inflammatory and anti-cancer activity (cytotoxic) against U937 leukemia cell lines
[作者:Chandrika, PM; Yakaiah, T; Rao, ARR; Narsaiah, B; Reddy, NC; Sridhar, V; Rao, JV,期刊:European Journal of Medicinal Chemistry, 页码:846-852 , 文章类型: Article,,卷期:2008年43-4]
In view of the link between use of NSAIDs and altered cancer incidence and a growing evidence of COX-H implication in angiogenesis, a novel series of 4,6-disubstituted quinazoline derivatives have been synthesized sta...
- An elegant synthesis of Zetaclausenamide
[作者:Ma, NC; Wu, KM; Huang, L,期刊:European Journal of Medicinal Chemistry, 页码:893-896 , 文章类型: Article,,卷期:2008年43-4]
Zetaclausenamide, which was isolated as a hepatoprotective agent from the leaves of medicinal plant Clausena lansium, was synthesized for the first time in six steps including Darzen's condensation, photoisomerization...
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