- Synthesis, characterization and biological activity of Pt(II) and Pt(IV) complexes with 5-methyl-5(4-pyridyl)-2,4-imidazolidenedione
[作者:Bakalova, A; Varbanov, H; Buyukliev, R; Momekov, G; Ferdinandov, D; Konstantinov, S; Ivanov, D,期刊:European Journal of Medicinal Chemistry, 页码:958-965 , 文章类型: Article,,卷期:2008年43-5]
New platinum(H) and platinum(IV) complexes with 5-methyl-5(4-pyridyl)-2,4-imidazolidenedione and various halogen ions with general formula [PtL2X2] and [PtL2Cl4], where L is the organic ligand and X is Cl-, Br-, J(-),...
- Structure-activity relationships of Bak derived peptides: Affinity and specificity modulations by amino acid replacement
[作者:Frey, V; Viaud, J; Subra, G; Cauquil, N; Guichou, JF; Casara, P; Grassy, G; Chavanieu, A,期刊:European Journal of Medicinal Chemistry, 页码:966-972 , 文章类型: Article,,卷期:2008年43-5]
To study the structure-activity relationships (SAR) and the binding activity of pro-apoptotic Bak BH3 domain, we synthesised several 16mer peptide analogues corresponding, to the region (72)-GQVGRQLAIIGDDINR-(87). Usi...
- Oxoisoaporphine alkaloid derivatives: Synthesis, DNA binding affinity and cytotoxicity
[作者:Tang, H; Wang, XD; Wei, YB; Huang, SL; Huang, ZS; Tan, JH; An, LK; Wu, JY; Chan, ASC; Gu, LQ,期刊:European Journal of Medicinal Chemistry, 页码:973-980 , 文章类型: Article,,卷期:2008年43-5]
A series of novel oxoisoaporphine alkaloid derivatives, 9-aminoalkanamido-1-azabenzanthrone (general formula Ar-NHCO(CH2)(n)NR2, Ar = 1-azabenzanthrone, n = 1, 2 or 3), had been synthesized. Compared with 1-azabenzant...
- Synthesis, properties, and perspectives of gem-diphosphono substituted-thiazoles
[作者:Abdou, WM; Ganoub, NA; Geronikaki, A; Sabry, E,期刊:European Journal of Medicinal Chemistry, 页码:1015-1024 , 文章类型: Article,,卷期:2008年43-5]
A series of substituted arylidene thiazoles were allowed to react with Wittig-Homer (WH) reagent, tetraethyl methyl-1,1-bisphosphonate, to produce via Michael addition reaction the corresponding heteroarylmethylenebis...
- A new class of analgesic agents toward prostacyclin receptor inhibition: Synthesis, biological studies and QSAR analysis of 1-hydroxyl-2-substituted phenyl-4,4,5,5-tetramethylimidazolines
[作者:Zhao, M; Li, Z; Peng, L; Tang, YR; Wang, C; Zhang, ZD; Peng, SQ,期刊:European Journal of Medicinal Chemistry, 页码:1048-1058 , 文章类型: Article,,卷期:2008年43-5]
By studying the structural similarity of analgesic imidazolines and 2-phenylnitronyl nitroxides, 20 1-hydroxyl-2-substituted phenyl-4,4,5,5-tetramethylimidazolines (2a-t) were newly synthesized as selective antagonist...
- Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor
[作者:Kiss, R; Noszal, B; Racz, A; Falus, A; Eros, D; Keseru, GM,期刊:European Journal of Medicinal Chemistry, 页码:1059-1070 , 文章类型: Article,,卷期:2008年43-5]
Ligand-supported homology models of the human histamine H4 receptor (hH4R) were developed based on the crystal structure of bovine rhodopsin and different known H4 ligands (histamine, OUP-16, JNJ7777120). Enrichment t...
- Synthesis, structure elucidation and identification of antitumoural properties of novel fused 1,2,4-triazine aryl derivatives
[作者:Sztanke, K; Pastemak, K; Rzymowska, J; Sztanke, M; Kandefer-Szerszen, M,期刊:European Journal of Medicinal Chemistry, 页码:1085-1094 , 文章类型: Article,,卷期:2008年43-5]
Synthesis, structure elucidation and anticancer activities of novel fused 1,2,4-triazine aryl derivatives containing the ethoxycarbonyl (6-10) and carbohydrazide formations (11-15) are presented. Molecular structures ...
|