- Synthesis, antitumor evaluation and DNA binding studies of novel amidino-benzimidazolyl substituted derivatives of furyl-phenyl- and thienyl-phenyl-acrylates, naphthofurans and naphthothiophenes
[作者:Hranjec, M; Starcevic, K; Piantanida, I; Kralj, M; Marjanovic, M; Hasani, M; Westman, G; Karlminski-Zamola, G,期刊:European Journal of Medicinal Chemistry, 页码:2877-2890 , 文章类型: Article,,卷期:2008年43-12]
A series of amidino-substituted benzimidazoles, related to furyl-phenyl- and thienyl-phenyl-acrylates, naphthofurans and naphthothiophenes were prepared, their antitumor evaluation and interactions with ct-DNA have be...
- Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrug of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease (Retraction of vol 42, pg 885, 2007)
[作者:Dhaneshwar, SS; Kandpal, M; Vadnerkar, G; Rathi, B; Kadam, SS,期刊:European Journal of Medicinal Chemistry, 页码:2909-2909 , 文章类型: Correction,,卷期:2008年43-12]
- Syntheses and cytotoxicities of the analogues of the taxoid brevifoliol (vol 43, pg 1499, 2008)
[作者:Chattopadhyay, SK; Tripathi, S; Darokar, MP; Faridi, U; Sisodia, B; Negi, S; Kumar, JK; Khanuja, SPS,期刊:European Journal of Medicinal Chemistry, 页码:2910-2910 , 文章类型: Correction,,卷期:2008年43-12]
- Rational design, synthesis and biological evaluation of new 1,5-diarylpyrazole derivatives as CB1 receptor antagonists, structurally related to rimonabant
[作者:Menozzi, G; Fossa, P; Cichero, E; Spallarossa, A; Ranise, A; Mosti, L,期刊:European Journal of Medicinal Chemistry, 页码:2627-2638 , 文章类型: Article,,卷期:2008年43-12]
Among cannabinoid type-1 (CB1) receptor antagonists, those developed around the 1,5-diarylpyrazole scaffold of rimonabant (Acomplia (TM)) are the most extensively investigated. In recent years, many SAR and QSAR repor...
- Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases
[作者:Bagihalli, GB; Avaji, PG; Patil, SA; Badami, PS,期刊:European Journal of Medicinal Chemistry, 页码:2639-2649 , 文章类型: Article,,卷期:2008年43-12]
A series of metal complexes of cobalt(H), nickel(II) and copper(II) have been synthesized with newly synthesized biologically active 1,2, 4-triazole Schiff bases derived from the condensation of 3-substituted-4-amino-...
- Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring
[作者:Do, Q; Mai, HDT; Gaslonde, T; Pfeiffer, B; Leonce, S; Pierre, A; Michel, S; Tillequin, F; Dufat, H,期刊:European Journal of Medicinal Chemistry, 页码:2677-2687 , 文章类型: Article,,卷期:2008年43-12]
In order to explore the structure-activity relationships in the acronycine series, simplified analogues of cis-1,2-diacetoxy-1,2-dihydroacronycine and cis-1,2-diacetoxy-1,2-dihydrobenzo[b]acronycine (S23906-1, under c...
- 2/4-Substituted-9-fluorenones and their O-glucosides as potential immunomodulators and anti-herpes simplex virus-2 agents. Part 5
[作者:Arena, A; Arena, N; Ciurleo, R; de Gregorio, A; Maccari, R; Ottana, R; Pavone, B; Tramice, A; Trincone, A; Vigorita, MG,期刊:European Journal of Medicinal Chemistry, 页码:2656-2664 , 文章类型: Article,,卷期:2008年43-12]
In pursuing a research on the antiviral and immunomodulatory activity of tilorone congeners, two new series of compounds were prepared and pharmacologically explored: 9-fluorenone carboxyhydroxyesters, indicated as AG...
- 1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: Synthesis and preliminary evaluation of biological properties
[作者:Kumar, H; Javed, SA; Khan, SA; Amir, M,期刊:European Journal of Medicinal Chemistry, 页码:2688-2698 , 文章类型: Article,,卷期:2008年43-12]
A series of 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid were synthesized in order to obtain new compounds with potential anti-inflammatory activity, analgesic activity a...
- Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents
[作者:Singh, BK; Mishra, M; Saxena, N; Yadav, GP; Maulik, PR; Sahoo, MK; Gaur, RL; Murthy, PK; Tripathi, RP,期刊:European Journal of Medicinal Chemistry, 页码:2717-2723 , 文章类型: Article,,卷期:2008年43-12]
A series of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines (8-21) were synthesized in good yields by alkylation of 5-methyl-6-phenyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid ethyl esters (2-7) with differen...
- Three-dimensional QSAR analyses of 1,3,4-trisubstituted pyrrolidine-based CCR5 receptor inhibitors
[作者:Zhuo, Y; Kong, R; Cong, XJ; Chen, WZ; Wang, CX,期刊:European Journal of Medicinal Chemistry, 页码:2724-2734 , 文章类型: Article,,卷期:2008年43-12]
In this study, a series of 1,3,4-trisubstituted pyrrolidine-based CCR5 receptor inhibitors were taken as our target with the method of the three-dimensional quantitative structure-activity relationship (3D-QSAR) analy...
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