- Pioglitazone-Induced Reductions in Atherosclerosis Occur via Smooth Muscle Cell-Specific Interaction With PPAR gamma
[作者:Subramanian, V; Golledge, J; Ijaz, T; Bruemmer, D; Daugherty, A,期刊:Circulation Research, 页码:953-958 , 文章类型: Article,,卷期:2010年107-8]
- Rationale: Peroxisome proliferator-activated receptor (PPAR)gamma agonists attenuate atherosclerosis and abdominal aortic aneurysms (AAAs). PPAR gamma, a nuclear receptor, is expressed on many cell types including smooth...
- Kruppel-Like Factor-4 Transcriptionally Regulates VE-Cadherin Expression and Endothelial Barrier Function
[作者:Cowan, CE; Kohler, EE; Dugan, TA; Mirza, MK; Malik, AB; Wary, KK,期刊:Circulation Research, 页码:959-U46 , 文章类型: Article,,卷期:2010年107-8]
- Rationale: Vascular endothelial (VE)-cadherin localized at adherens junctions (AJs) regulates endothelial barrier function. Because WNT (wingless) signaling-induced activation of the transcription factor Kruppel-like fac...
- Upregulation of Nox4 by TGF beta 1 Oxidizes SERCA and Inhibits NO in Arterial Smooth Muscle of the Prediabetic Zucker Rat
[作者:Tong, XY; Hou, XY; Jourd'heuil, D; Weisbrod, RM; Cohen, RA,期刊:Circulation Research, 页码:975-U79 , 文章类型: Article,,卷期:2010年107-8]
- Rationale: Vascular smooth muscle cell (SMC) migration is an important pathological process in several vascular occlusive diseases, including atherosclerosis and restenosis, both of which are accelerated by diabetes mell...
- Bone Morphogenic Protein-4 Impairs Endothelial Function Through Oxidative Stress-Dependent Cyclooxygenase-2 Upregulation Implications on Hypertension
[作者:Wong, WT; Tian, XY; Chen, YC; Leung, FP; Liu, LM; Lee, HK; Ng, CF; Xu, AM; Yao, XQ; Vanhoutte, PM; Tipoe, GL; Huang, Y,期刊:Circulation Research, 页码:984-U95 , 文章类型: Article,,卷期:2010年107-8]
- Rationale: Bone morphogenic protein (BMP)4 can stimulate superoxide production and exert proinflammatory effects on the endothelium. The underlying mechanisms of how BMP4 mediates endothelial dysfunction and hypertension...
- Disruption of Protein Arginine N-Methyltransferase 2 Regulates Leptin Signaling and Produces Leanness In Vivo Through Loss of STAT3 Methylation
[作者:Iwasaki, H; Kovacic, JC; Olive, M; Beers, JK; Yoshimoto, T; Crook, MF; Tonelli, LH; Nabel, EG,期刊:Circulation Research, 页码:992-1001 , 文章类型: Article,,卷期:2010年107-8]
- Rationale: Arginine methylation by protein N-arginine methyltransferases (PRMTs) is an important posttranslational modification in the regulation of protein signaling. PRMT2 contains a highly conserved catalytic Ado-Met ...
- Enhanced Fibroblast-Myocyte Interactions in Response to Cardiac Injury
[作者:Vasquez, C; Mohandas, P; Louie, KL; Benamer, N; Bapat, AC; Morley, GE,期刊:Circulation Research, 页码:1011-U139 , 文章类型: Article,,卷期:2010年107-8]
- Rationale: A critical event in the development of cardiac fibrosis is the transformation of fibroblasts into myofibroblasts. The electrophysiological consequences of this phenotypic switch remain largely unknown. Objecti...
- DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome
[作者:Mercer, JR; Cheng, KK; Figg, N; Gorenne, I; Mahmoudi, M; Griffin, J; Vidal-Puig, A; Logan, A; Murphy, MP; Bennett, M,期刊:Circulation Research, 页码:1021-U159 , 文章类型: Article,,卷期:2010年107-8]
- Rationale: DNA damage is present in both genomic and mitochondrial DNA in atherosclerosis. However, whether DNA damage itself promotes atherosclerosis, or is simply a byproduct of the risk factors that promote atheroscle...
- The Transcription Factor GATA-6 Regulates Pathological Cardiac Hypertrophy
[作者:van Berlo, JH; Elrod, JW; van den Hoogenhof, MMG; York, AJ; Aronow, BJ; Duncan, SA; Molkentin, JD,期刊:Circulation Research, 页码:1032-U178 , 文章类型: Article,,卷期:2010年107-8]
- Rationale: The transcriptional code that programs maladaptive cardiac hypertrophy involves the zinc finger-containing DNA binding factor GATA-4. The highly related transcription factor GATA-6 is also expressed in the adu...
|