- The E. coli CsgB nucleator of curli assembles to beta-sheet oligomers that alter the CsgA fibrillization mechanism
[作者:Shu, Q; Crick, SL; Pinkner, JS; Ford, B; Hultgren, SJ; Frieden, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6502-6507 , 文章类型: Article,,卷期:2012年109-17]
- Curli are extracellular proteinaceous functional amyloid aggregates produced by Escherichia coli, Salmonella spp., and other enteric bacteria. Curli mediate host cell adhesion and invasion and play a critical role in bio...
- Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography
[作者:Schregel, K; Tysiak, EWN; Garteiser, P; Gemeinhardt, I; Prozorovski, T; Aktas, O; Merz, H; Petersen, D; Wuerfel, J; Sinkus, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6650-6655 , 文章类型: Article,,卷期:2012年109-17]
- The detection of pathological tissue alterations by manual palpation is a simple but essential diagnostic tool, which has been applied by physicians since the beginnings of medicine. Recently, the virtual "palpation" of ...
- Game-powered machine learning
[作者:Barrington, L; Turnbull, D; Lanckriet, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6411-6416 , 文章类型: Article,,卷期:2012年109-17]
- Searching for relevant content in a massive amount of multimedia information is facilitated by accurately annotating each image, video, or song with a large number of relevant semantic keywords, or tags. We introduce gam...
- ParA-like protein uses nonspecific chromosomal DNA binding to partition protein complexes
[作者:Roberts, MAJ; Wadhams, GH; Hadfield, KA; Tickner, S; Armitage, JP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6698-6703 , 文章类型: Article,,卷期:2012年109-17]
- Recent data have shown that plasmid partitioning Par-like systems are used by some bacterial cells to control localization of protein complexes. Here we demonstrate that one of these homologs, PpfA, uses nonspecific chro...
- Patient sharing and population genetic structure of methicillin-resistant Staphylococcus aureus
[作者:Ke, WX; Huang, SS; Hudson, LO; Elkins, KR; Nguyen, CC; Spratt, BG; Murphy, CR; Avery, TR; Lipsitch, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6763-6768 , 文章类型: Article,,卷期:2012年109-17]
- Rates of hospital-acquired infections, specifically methicillin-resistant Staphylococcus aureus (MRSA), are increasingly being used as indicators for quality of hospital hygiene. There has been much effort on understandi...
- Shaggy/glycogen synthase kinase 3 beta and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis
[作者:Takeo, S; Swanson, SK; Nandanan, K; Nakai, Y; Aigaki, T; Washburn, MP; Florens, L; Hawley, RS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6382-6389 , 文章类型: Article,,卷期:2012年109-17]
- The Ca2+/Calmodulin-dependent phosphatase calcineurin is essential for exit from meiotic arrest at metaphases I and II in Drosophila and Xenopus oocytes. We previously found that Sarah, the Drosophila homolog of regulato...
- Thermodynamic glass transition in a spin glass without time-reversal symmetry
[作者:Banos, RA; Cruz, A; Fernandez, LA; Gil-Narvion, JM; Gordillo-Guerrero, A; Guidetti, M; Iniguez, D; Maiorano, A; Marinari, E; Martin-Mayor, V; Monforte-Garcia, J; Sudupe, AM; Navarro, D; Parisi, G; Perez-Gaviro, S; Ruiz-Lorenzo, JJ; Schifano, SF; Seoane, B; Tarancon, A; Tellez, P; Tripiccione, R; Yllanes, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6452-6456 , 文章类型: Article,,卷期:2012年109-17]
- Spin glasses are a longstanding model for the sluggish dynamics that appear at the glass transition. However, spin glasses differ from structural glasses in a crucial feature: they enjoy a time reversal symmetry. This sy...
- Bax regulates primary necrosis through mitochondrial dynamics
[作者:Whelan, RS; Konstantinidis, K; Wei, AC; Chen, Y; Reyna, DE; Jha, S; Yang, Y; Calvert, JW; Lindsten, T; Thompson, CB; Crow, MT; Gavathiotis, E; Dorn, GW; O'Rourke, B; Kitsis, RN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6566-6571 , 文章类型: Article,,卷期:2012年109-17]
- The defining event in apoptosis is mitochondrial outer membrane permeabilization (MOMP), allowing apoptogen release. In contrast, the triggering event in primary necrosis is early opening of the inner membrane mitochondr...
- Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts
[作者:Liu, SB; Li, Y; Kim, SJ; Fu, Q; Parikh, D; Sridhar, B; Shi, Q; Zhang, XY; Guan, YZ; Chen, XW; Xiang, YK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6578-6583 , 文章类型: Article,,卷期:2012年109-17]
- Inflammation is a significant player in the progression of heart failure and has detrimental effects on cardiac function. Prostaglandin (PG)E2, a major proinflammatory prostanoid in the cardiovascular system, is a potent...
- Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice
[作者:Yu, Z; Crichton, I; Tang, SY; Hui, YQ; Ricciotti, E; Levin, MD; Lawson, JA; Pure, E; FitzGerald, GA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6727-6732 , 文章类型: Article,,卷期:2012年109-17]
- Suppression of cyclooxygenase 2 (COX-2)-derived prostacyclin (PGI(2)) is sufficient to explain most elements of the cardiovascular hazard from nonsteroidal antinflammatory drugs (NSAIDs). However, randomized trials are c...
- Greater focus needed on methane leakage from natural gas infrastructure
[作者:Alvarez, RA; Pacala, SW; Winebrake, JJ; Chameides, WL; Hamburg, SP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6435-6440 , 文章类型: Article,,卷期:2012年109-17]
- Natural gas is seen by many as the future of American energy: a fuel that can provide energy independence and reduce greenhouse gas emissions in the process. However, there has also been confusion about the climate impli...
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