- Allosteric inhibitors of chemoattractant receptors: opportunities and pitfalls
[作者:Allegretti, M; Bertin, R; Bizzarri, C; Beccari, A; Mantovani, A; Locati, M,期刊:Trends in Pharmacological Sciences, 页码:280-286 , 文章类型: Review,,卷期:2008年29-6]
Given the central role of chemokines in infection, inflammation and immunity, chemokine receptors are a prime target for pharmacological intervention, and more so after the recent approval of chemokine receptor inhibi...
- Flavin-containing monooxygenases: mutations, disease and drug response
[作者:Phillips, IR; Shephard, EA,期刊:Trends in Pharmacological Sciences, 页码:294-301 , 文章类型: Review,,卷期:2008年29-6]
Flavin-containing monooxygenases (FMOs) metabolize numerous foreign chemicals, including drugs, pesticides and dietary components and, thus, mediate interactions between humans and their chemical environment. We descr...
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