- Brain TRPV1: a depressing TR(i)P down memory lane?
[作者:Di Marzo, V; Gobbi, G; Szaallasi, A,期刊:Trends in Pharmacological Sciences, 页码:594-600 , 文章类型: Review,,卷期:2008年29-12]
On sensory neurons, the capsaicin receptor TRPV1 (transient receptor potential, vanilloid subfamily, member 1) functions as a molecular integrator of noxious stimuli and represents a novel target for analgesic drugs. ...
- Nitroxyl (HNO): the Cinderella of the nitric oxide story
[作者:Irvine, JC; Ritchie, RH; Favaloro, JL; Andrews, KL; Widdop, RE; Kemp-Harper, BK,期刊:Trends in Pharmacological Sciences, 页码:601-608 , 文章类型: Review,,卷期:2008年29-12]
Until recently, most of the biological effects of nitric oxide (NO) have been attributed to its uncharged state (NO degrees), yet NO can also exist in the reduced state as nitroxyl (HNO or NO-). Putatively generated f...
- Conformational changes involved in G-protein-coupled-receptor activation
[作者:Wess, J; Han, SJ; Kim, SK; Jacobson, KA; Li, JH,期刊:Trends in Pharmacological Sciences, 页码:616-625 , 文章类型: Review,,卷期:2008年29-12]
Little is known about the nature of the conformational changes that convert G-protein-coupled receptors (GPCRs), which bind diffusible ligands, from their resting into their active states. To gain structural insight i...
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