- Analysis of Transcriptome Complexity Through RNA Sequencing in Normal and Failing Murine Hearts
[作者:Lee, JH; Gao, C; Peng, GD; Greer, C; Ren, SX; Wang, YB; Xiao, XS,期刊:Circulation Research, 页码:1332-1341 , 文章类型: Article,,卷期:2011年109-12]
- Rationale: Accurate and comprehensive de novo transcriptome profiling in heart is a central issue to better understand cardiac physiology and diseases. Although significant progress has been made in genome-wide profiling...
- Nuclear Plakoglobin Is Essential for Differentiation of Cardiac Progenitor Cells to Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy
[作者:Lombardi, R; Cabreira-Hansen, MD; Bell, A; Fromm, RR; Willerson, JT; Marian, AJ,期刊:Circulation Research, 页码:1342-NIL_86 , 文章类型: Article,,卷期:2011年109-12]
- Rationale: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease of desmosome proteins characterized by fibroadipogenesis in the myocardium. We have implicated signaling properties of junction protein plako...
- Wnt Signaling Exerts an Antiproliferative Effect on Adult Cardiac Progenitor Cells Through IGFBP3
[作者:Oikonomopoulos, A; Sereti, KI; Conyers, F; Bauer, M; Liao, A; Guan, J; Crapps, D; Han, JK; Dong, HH; Bayomy, AF; Fine, GC; Westerman, K; Biechele, TL; Moon, RT; Force, T; Liao, RL,期刊:Circulation Research, 页码:1363-1374 , 文章类型: Article,,卷期:2011年109-12]
- Rationale: Recent work in animal models and humans has demonstrated the presence of organ-specific progenitor cells required for the regenerative capacity of the adult heart. In response to tissue injury, progenitor cell...
- Nitrite-Mediated S-Nitrosylation of Caspase-3 Prevents Hypoxia-Induced Endothelial Barrier Dysfunction
[作者:Lai, YC; Pan, KT; Chang, GF; Hsu, CH; Khoo, KH; Hung, CH; Jiang, YJ; Ho, FM; Meng, TC,期刊:Circulation Research, 页码:1375-1386 , 文章类型: Article,,卷期:2011年109-12]
- Rationale: Hypoxia is a significant perturbation that exacerbates endothelial barrier dysfunction, contributing to the disruption of vascular homeostasis and the development of various diseases such as atherosclerosis an...
- Plasmacytoid Dendritic Cells Protect Against Atherosclerosis by Tuning T-Cell Proliferation and Activity
[作者:Daissormont, ITMN; Christ, A; Temmerman, L; Millares, SS; Seijkens, T; Manca, M; Rousch, M; Poggi, M; Boon, L; van der Loos, C; Daemen, M; Lutgens, E; Halvorsen, B; Aukrust, P; Janssen, E; Biessen, EAL,期刊:Circulation Research, 页码:1387-1395 , 文章类型: Article,,卷期:2011年109-12]
- Rationale: Unlike conventional dendritic cells, plasmacytoid DCs (PDC) are poor in antigen presentation and critical for type 1 interferon response. Though proposed to be present in human atherosclerotic lesions, their r...
- Inhibition of PKC alpha/beta With Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury
[作者:Ladage, D; Tilemann, L; Ishikawa, K; Correll, RN; Kawase, Y; Houser, SR; Molkentin, JD; Hajjar, RJ,期刊:Circulation Research, 页码:1396-1400 , 文章类型: Article,,卷期:2011年109-12]
- Rationale: Protein kinase C alpha (PKC alpha) activity and protein level are induced during cardiac disease where it controls myocardial contractility and propensity to heart failure in mice and rats. For example, mice l...
- A Novel Preclinical Strategy for Identifying Cardiotoxic Kinase Inhibitors and Mechanisms of Cardiotoxicity
[作者:Cheng, H; Kari, G; Dicker, AP; Rodeck, U; Koch, WJ; Force, T,期刊:Circulation Research, 页码:1401-NIL_157 , 文章类型: Article,,卷期:2011年109-12]
- Rationale: Despite intense interest in strategies to predict which kinase inhibitor (KI) cancer therapeutics may be associated with cardiotoxicity, current approaches are inadequate. Sorafenib is a KI of concern because ...
- Thrombospondin-4 Is Required for Stretch-Mediated Contractility Augmentation in Cardiac Muscle
[作者:Cingolani, OH; Kirk, JA; Seo, K; Koitahashi, N; Lee, DI; Ramirez-Correa, G; Bedja, D; Barth, AS; Moens, AL; Kass, DA,期刊:Circulation Research, 页码:1410-1414 , 文章类型: Article,,卷期:2011年109-12]
- Rationale: One of the physiological mechanisms by which the heart adapts to a rise in blood pressure is by augmenting myocyte stretch-mediated intracellular calcium, with a subsequent increase in contractility. This slow...
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