- Viral Gene Transfer Rescues Arrhythmogenic Phenotype and Ultrastructural Abnormalities in Adult Calsequestrin-Null Mice With Inherited Arrhythmias
[作者:Denegri, M; Avelino-Cruz, JE; Boncompagni, S; De Simone, SA; Auricchio, A; Villani, L; Volpe, P; Protasi, F; Napolitano, C; Priori, SG,期刊:Circulation Research, 页码:663-U49 , 文章类型: Article,,卷期:2012年110-5]
- Rationale: Catecholaminergic polymorphic ventricular tachycardia is an inherited disease that predisposes to cardiac arrest and sudden death. The disease is associated with mutations in the genes encoding for the cardiac...
- A Caveolae-Targeted L-Type Ca2+ Channel Antagonist Inhibits Hypertrophic Signaling Without Reducing Cardiac Contractility
[作者:Makarewich, CA; Correll, RN; Gao, H; Zhang, HY; Yang, BH; Berretta, RM; Rizzo, V; Molkentin, JD; Houser, SR,期刊:Circulation Research, 页码:669-U60 , 文章类型: Article,,卷期:2012年110-5]
- Rationale: The source of Ca2+ to activate pathological cardiac hypertrophy is not clearly defined. Ca2+ influx through the L-type Ca2+ channels (LTCCs) determines "contractile" Ca2+, which is not thought to be the source...
- The IL-17A/IL-17RA Axis Plays a Proatherogenic Role via the Regulation of Aortic Myeloid Cell Recruitment
[作者:Butcher, MJ; Gjurich, BN; Phillips, T; Galkina, EV,期刊:Circulation Research, 页码:675-U79 , 文章类型: Article,,卷期:2012年110-5]
- Rationale: Atherosclerosis is a disease of large- and medium-sized arteries that is characterized by chronic vascular inflammation. While the role of Th1, Th2, and T-regulatory subsets in atherogenesis is established, th...
- Ephrin-B1 Is a Novel Specific Component of the Lateral Membrane of the Cardiomyocyte and Is Essential for the Stability of Cardiac Tissue Architecture Cohesion
[作者:Genet, G; Guilbeau-Frugier, C; Honton, B; Dague, E; Schneider, MD; Coatrieux, C; Calise, D; Cardin, C; Nieto, C; Payre, B; Dubroca, C; Marck, P; Heymes, C; Dubrac, A; Arvanitis, D; Despas, F; Altie, MF; Seguelas, MH; Delisle, MB; Davy, A; Senard, JM; Pathak, A; Gales, C,期刊:Circulation Research, 页码:688-U117 , 文章类型: Article,,卷期:2012年110-5]
- Rationale: Cardiac tissue cohesion relying on highly ordered cardiomyocytes (CM) interactions is critical because most cardiomyopathies are associated with tissue remodeling and architecture alterations. Objective: Eph/e...
- Cardiomyogenesis in the Developing Heart Is Regulated by C-Kit-Positive Cardiac Stem Cells
[作者:Ferreira-Martins, J; Ogorek, B; Cappetta, D; Matsuda, A; Signore, S; D'Amario, D; Kostyla, J; Steadman, E; Ide-Iwata, N; Sanada, F; Iaffaldano, G; Ottolenghi, S; Hosoda, T; Leri, A; Kajstura, J; Anversa, P; Rota, M,期刊:Circulation Research, 页码:701-U171 , 文章类型: Article,,卷期:2012年110-5]
- Rationale: Embryonic and fetal myocardial growth is characterized by a dramatic increase in myocyte number, but whether the expansion of the myocyte compartment is dictated by activation and commitment of resident cardia...
- Necl-5/Poliovirus Receptor Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis
[作者:Kinugasa, M; Amano, H; Satomi-Kobayashi, S; Nakayama, K; Miyata, M; Kubo, Y; Nagamatsu, Y; Kurogane, Y; Kureha, F; Yamana, S; Hirata, K; Miyoshi, J; Takai, Y; Rikitake, Y,期刊:Circulation Research, 页码:716-U197 , 文章类型: Article,,卷期:2012年110-5]
- Rationale: Vascular endothelial growth factor (VEGF), a major proangiogenic agent, exerts its proangiogenic action by binding to VEGF receptor 2 (VEGFR2), the activity of which is regulated by direct interactions with ot...
- Inhalation of Nitric Oxide Prevents Ischemic Brain Damage in Experimental Stroke by Selective Dilatation of Collateral Arterioles
[作者:Terpolilli, NA; Kim, SW; Thal, SC; Kataoka, H; Zeisig, V; Nitzsche, B; Klaesner, B; Zhu, CL; Schwarzmaier, S; Meissner, L; Mamrak, U; Engel, DC; Drzezga, A; Patel, RP; Blomgren, K; Barthel, H; Boltze, J; Kuebler, WM; Plesnila, N,期刊:Circulation Research, 页码:727-U227 , 文章类型: Article,,卷期:2012年110-5]
- Rationale: Stroke is the third most common cause of death in industrialized countries. The main therapeutic target is the ischemic penumbra, potentially salvageable brain tissue that dies within the first few hours after...
- Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism
[作者:Cavasin, MA; Demos-Davies, K; Horn, TR; Walker, LA; Lemon, DD; Birdsey, N; Weiser-Evans, MCM; Harral, J; Irwin, DC; Anwar, A; Yeager, ME; Li, M; Watson, PA; Nemenoff, RA; Buttrick, PM; Stenmark, KR; McKinsey, TA,期刊:Circulation Research, 页码:739-U250 , 文章类型: Article,,卷期:2012年110-5]
- Rationale: Histone deacetylase (HDAC) inhibitors are efficacious in models of hypertension-induced left ventricular heart failure. The consequences of HDAC inhibition in the context of pulmonary hypertension with associa...
- Gene Therapy for Heart Failure
[作者:Tilemann, L; Ishikawa, K; Weber, T; Hajjar, RJ,期刊:Circulation Research, 页码:777-793 , 文章类型: Review,,卷期:2012年110-5]
- Congestive heart failure accounts for half a million deaths per year in the United States. Despite its place among the leading causes of morbidity, pharmacological and mechanic remedies have only been able to slow the pr...
- Response to Letter by Zaugg et al: STAT5 Activation and Cardioprotection By Remote Ischemic Preconditioning in Patients Undergoing Coronary Revascularization During Isoflurane Anesthesia
[作者:Heusch, G; Musiolik, J; Kottenberg, E; Peters, J; Jakob, H; Thielmann, M,期刊:Circulation Research, 页码:E44-E45 , 文章类型: Letter,,卷期:2012年110-5]
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