- A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain
[作者：Sing, A; Pannell, D; Karaiskakis, A; Sturgeon, K; Djabali, M; Ellis, J; Lipshitz, HD; Cordes, SP,期刊：Cell, 页码：885-897 , 文章类型： Article，,卷期：2009年138-5]
- Chromatin remodeling by Polycomb group (PcG) and trithorax group (trxG) proteins regulates gene expression in all metazoans. Two major complexes, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2), are thought to medi...
- Regulation of Vertebrate Nervous System Alternative Splicing and Development by an SR-Related Protein
[作者：Calarco, JA; Superina, S; O'Hanlon, D; Gabut, M; Raj, B; Pan, Q; Skalska, U; Clarke, L; Gelinas, D; van der Kooy, D; Zhen, M; Ciruna, B; Blencowe, BJ,期刊：Cell, 页码：898-910 , 文章类型： Article，,卷期：2009年138-5]
- Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing n...
- Mechanochemical Removal of Ribosome Biogenesis Factors from Nascent 60S Ribosomal Subunits
[作者：Ulbrich, C; Diepholz, M; Bassler, J; Kressler, D; Pertschy, B; Galani, K; Bottcher, B; Hurt, E,期刊：Cell, 页码：911-922 , 文章类型： Article，,卷期：2009年138-5]
- The dynein-related AAA ATPase Rea1 is a preribosomal factor that triggers an unknown maturation step in 60S subunit biogenesis. Using electron microscopy, we show that Rea1's motor domain is docked to the pre-60S particl...
- Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes
[作者：de Wit, H; Walter, AM; Milosevic, I; Gulyas-Kovacs, A; Riedel, D; Sorensen, JB; Verhage, M,期刊：Cell, 页码：935-946 , 文章类型： Article，,卷期：2009年138-5]
- Docking, the initial association of secretory vesicles with the plasma membrane, precedes formation of the SNARE complex, which drives membrane fusion. For many years, the molecular identity of the docked state, and espe...
- A Synaptic Vesicle-Associated Ca2+ Channel Promotes Endocytosis and Couples Exocytosis to Endocytosis
[作者：Yao, CK; Lin, YQ; Ly, CV; Ohyama, T; Haueter, CM; Moiseenkova-Bell, VY; Wensel, TG; Bellen, HJ,期刊：Cell, 页码：947-960 , 文章类型： Article，,卷期：2009年138-5]
- Synaptic vesicle (SV) exo- and endocytosis are tightly coupled to sustain neurotransmission in presynaptic terminals, and both are regulated by Ca2+. Ca2+ influx triggered by voltage-gated Ca2+ channels is necessary for ...
- The Protein Kinase IKK epsilon Regulates Energy Balance in Obese Mice
[作者：Chiang, SH; Bazuine, M; Lumeng, CN; Geletka, LM; Mowers, J; White, NM; Ma, JT; Zhou, J; Qi, N; Westcott, D; Delproposto, JB; Blackwell, TS; Yull, FE; Saltiel, AR,期刊：Cell, 页码：961-975 , 文章类型： Article，,卷期：2009年138-5]
- Obesity is associated with chronic low-grade inflammation that negatively impacts insulin sensitivity. Here, we show that high-fat diet can increase NF-kappa B activation in mice, which leads to a sustained elevation in ...
- A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure
[作者：Yadav, VK; Oury, F; Suda, N; Liu, ZW; Gao, XB; Confavreux, C; Klemenhagen, KC; Tanaka, KF; Gingrich, JA; Guo, XE; Tecott, LH; Mann, JJ; Hen, R; Horvath, TL; Karsenty, G,期刊：Cell, 页码：976-989 , 文章类型： Article，,卷期：2009年138-5]
- Leptin inhibition of bone mass accrual requires the integrity of specific hypothalamic neurons but not expression of its receptor on these neurons. The same is true for its regulation of appetite and energy expenditure. ...
- The F-BAR Domain of srGAP2 Induces Membrane Protrusions Required for Neuronal Migration and Morphogenesis
[作者：Guerrier, S; Coutinho-Budd, J; Sassa, T; Gresset, A; Jordan, NV; Chen, K; Jin, WL; Frost, A; Polleux, F,期刊：Cell, 页码：990-1004 , 文章类型： Article，,卷期：2009年138-5]
- During brain development, proper neuronal migration and morphogenesis is critical for the establishment of functional neural circuits. Here we report that srGAP2 negatively regulates neuronal migration and induces neurit...
- Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes
[作者：Wang, ZB; Zang, CZ; Cui, KR; Schones, DE; Barski, A; Peng, WQ; Zhao, KJ,期刊：Cell, 页码：1019-1031 , 文章类型： Article，,卷期：2009年138-5]
- Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HD...
- Caspases and Kinases in a Death Grip
[作者：Kurokawa, M; Kornbluth, S,期刊：Cell, 页码：838-854 , 文章类型： Review，,卷期：2009年138-5]
- The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidence suggests that cell death pathways are finely tuned by multiple signa...
|