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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共22条记录   Transposon Silencing by piRNAs [作者：Halic, M; Moazed, D,期刊：Cell, 页码：1058-1060 , 文章类型： Article，,卷期：2009年138-6] In animal cells, small RNA molecules, called piRNAs, defend the genome against selfish DNA elements such as transposons. In this issue, Klattenhoff et al. (2009) report that an HP1 family protein, Rhino, is required for ... p53: A New Kingpin in the Stem Cell Arena [作者：Aparicio, S; Eaves, CJ,期刊：Cell, 页码：1060-1062 , 文章类型： Article，,卷期：2009年138-6] Identifying new regulators of the stem cell state offers potential for future gains in biomedicine. Evidence that the tumor suppressor p53 is a key regulator of the stem cell state (Cicalese et al., 2009) suggests a broa... Reducing the Mystery of Neuronal Differentiation [作者：Novitch, BG; Butler, SJ,期刊：Cell, 页码：1062-1064 , 文章类型： Article，,卷期：2009年138-6] In the developing nervous system, neural progenitors exit the cell cycle and differentiate on a precise schedule, yet the mechanisms driving this process remain poorly defined. Yan et al. ( 2009) now identify a thiol-red... A Toggle Switch in Plant Nitrate Uptake [作者：Vert, G; Chory, J,期刊：Cell, 页码：1064-1066 , 文章类型： Article，,卷期：2009年138-6] In plants, the uptake of nitrate from the soil is a critical process controlled by complex regulatory networks that target nitrate transporters in the roots. In this issue, Ho et al. (2009) show that phosphorylation of t... The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells [作者：Cicalese, A; Bonizzi, G; Pasi, CE; Faretta, M; Ronzoni, S; Giulini, B; Brisken, C; Minucci, S; Di Fiore, PP; Pelicci, PG,期刊：Cell, 页码：1083-1095 , 文章类型： Article，,卷期：2009年138-6] Stem-like cells may be integral to the development and maintenance of human cancers. Direct proof is still lacking, mainly because of our poor understanding of the biological differences between normal and cancer stem ce... Molecular Architecture of the Mos1 Paired-End Complex: The Structural Basis of DNA Transposition in a Eukaryote [作者：Richardson, JM; Colloms, SD; Finnegan, DJ; Walkinshaw, MD,期刊：Cell, 页码：1096-1108 , 文章类型： Article，,卷期：2009年138-6] A key step in cut-and-paste DNA transposition is the pairing of transposon ends before the element is excised and inserted at a new site in its host genome. Crystallographic analyses of the paired-end complex (PEC) forme... Recombinational Repair within Heterochromatin Requires ATP-Dependent Chromatin Remodeling [作者：Sinha, M; Watanabe, S; Johnson, A; Moazed, D; Peterson, CL,期刊：Cell, 页码：1109-1121 , 文章类型： Article，,卷期：2009年138-6] Heterochromatin plays a key role in protection of chromosome integrity by suppressing homologous recombination. In Saccharomyces cerevisiae, Sir2p, Sir3p, and Sir4p are structural components of heterochromatin found at t... Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation [作者：Zippo, A; Serafini, R; Rocchigiani, M; Pennacchini, S; Krepelova, A; Oliviero, S,期刊：Cell, 页码：1122-1136 , 文章类型： Article，,卷期：2009年138-6] The phosphorylation of the serine 10 at histone H3 has been shown to be important for transcriptional activation. Here, we report the molecular mechanism through which H3S10ph triggers transcript elongation of the FOSL1 ... The Drosophila HP1 Homolog Rhino Is Required for Transposon Silencing and piRNA Production by Dual-Strand Clusters [作者：Klattenhoff, C; Xi, HL; Li, CJ; Lee, S; Xu, J; Khurana, JS; Zhang, F; Schultz, N; Koppetsch, BS; Nowosielska, A; Seitz, H; Zamore, PD; Weng, ZP; Theurkauf, WE,期刊：Cell, 页码：1137-1149 , 文章类型： Article，,卷期：2009年138-6] Piwi-interacting RNAs (piRNAs) silence transposons and maintain genome integrity during germline development. In Drosophila, transposon-rich heterochromatic clusters encode piRNAs either on both genomic strands (dual-str... Identification of an Aurora-A/Pins(LINKER)/Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells [作者：Johnston, CA; Hirono, K; Prehoda, KE; Doe, CQ,期刊：Cell, 页码：1150-1163 , 文章类型： Article，,卷期：2009年138-6] Asymmetric cell division is intensely studied because it can generate cellular diversity as well as maintain stem cell populations. Asymmetric cell division requires mitotic spindle alignment with intrinsic or extrinsic ... Detecting Folding Intermediates of a Protein as It Passes through the Bacterial Translocation Channel [作者：Kadokura, H; Beckwith, J,期刊：Cell, 页码：1164-1173 , 文章类型： Article，,卷期：2009年138-6] Most bacterial exported proteins cross the cytoplasmic membrane as unfolded polypeptides. However, little is known about how they fold during or after this process due to the difficulty in detecting folding intermediates... Kinesin-8 Motors Act Cooperatively to Mediate Length-Dependent Microtubule Depolymerization [作者：Varga, V; Leduc, C; Bormuth, V; Diez, S; Howard, J,期刊：Cell, 页码：1174-1183 , 文章类型： Article，,卷期：2009年138-6] Motor proteins in the kinesin-8 family depolymerize microtubules in a length-dependent manner that may be crucial for controlling the length of organelles such as the mitotic spindle. We used single-molecule microscopy t... CHL1 Functions as a Nitrate Sensor in Plants [作者：Ho, CH; Lin, SH; Hu, HC; Tsay, YF,期刊：Cell, 页码：1184-1194 , 文章类型： Article，,卷期：2009年138-6] Ions serve as essential nutrients in higher plants and can also act as signaling molecules. Little is known about how plants sense changes in soil nutrient concentrations. Previous studies showed that T101-phosphorylated... Actomyosin Is the Main Driver of Interkinetic Nuclear Migration in the Retina [作者：Norden, C; Young, S; Link, BA; Harris, WA,期刊：Cell, 页码：1195-1208 , 文章类型： Article，,卷期：2009年138-6] Progenitor cell nuclei in the rapidly expanding epithelium of the embryonic vertebrate central nervous system undergo a process called interkinetic nuclear migration (IKNM). Movements of IKNM are generally believed to... The Antioxidant Enzyme Prdx1 Controls Neuronal Differentiation by Thiol-Redox-Dependent Activation of GDE2 [作者：Yan, Y; Sabharwal, P; Rao, M; Sockanathan, S,期刊：Cell, 页码：1209-1221 , 文章类型： Article，,卷期：2009年138-6] The six-transmembrane protein GDE2 controls the onset and progression of spinal motor neuron differentiation through extracellular glycerophosphodiester phosphodiesterase metabolism. Although this process is likely to be... Synaptic PRG-1 Modulates Excitatory Transmission via Lipid Phosphate-Mediated Signaling [作者：Trimbuch, T; Beed, P; Vogt, J; Schuchmann, S; Maier, N; Kintscher, M; Breustedt, J; Schuelke, M; Streu, N; Kieselmann, O; Brunk, I; Laube, G; Strauss, U; Battefeld, A; Wende, H; Birchmeier, C; Wiese, S; Sendtner, M; Kawabe, H; Kishimoto-Suga, M; Brose, N; Baumgart, J; Geist, B; Aoki, J; Savaskan, NE; Brauer, AU; Chun, J; Ninnemann, O; Schmitz, D; Nitsch, R,期刊：Cell, 页码：1222-1235 , 文章类型： Article，,卷期：2009年138-6] Plasticity related gene-1 (PRG-1) is a brain-specific membrane protein related to lipid phosphate phosphatases, which acts in the hippocampus specifically at the excitatory synapse terminating on glutamatergic neurons. D...