- Estrogen Masculinizes Neural Pathways and Sex-Specific Behaviors
[作者：Wu, MV; Manoli, DS; Fraser, EJ; Coats, JK; Tollkuhn, J; Honda, SI; Harada, N; Shah, NM,期刊：Cell, 页码：61-72 , 文章类型： Article，,卷期：2009年139-1]
- Sex hormones are essential for neural circuit development and sex-specific behaviors. Male behaviors require both testosterone and estrogen, but it is unclear how the two hormonal pathways intersect. Circulating testoste...
- Condensins Regulate Meiotic DNA Break Distribution, thus Crossover Frequency, by Controlling Chromosome Structure
[作者：Mets, DG; Meyer, BJ,期刊：Cell, 页码：73-86 , 文章类型： Article，,卷期：2009年139-1]
- Meiotic crossover (CO) recombination facilitates evolution and accurate chromosome segregation. CO distribution is tightly regulated: homolog pairs receive at least one CO, CO spacing is nonrandom, and COs occur preferen...
- Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair
[作者：Williams, RS; Dodson, GE; Limbo, O; Yamada, Y; Williams, JS; Guenther, G; Classen, S; Glover, JNM; Iwasaki, H; Russell, P; Tainer, JA,期刊：Cell, 页码：87-99 , 文章类型： Article，,卷期：2009年139-1]
- The Nijmegen breakage syndrome 1 (Nbs1) subunit of the Mre11-Rad50-Nbs1 (MRN) complex protects genome integrity by coordinating double-strand break (DSB) repair and checkpoint signaling through undefined interactions wit...
- A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage
[作者：Lloyd, J; Chapman, JR; Clapperton, JA; Haire, LF; Hartsuiker, E; Li, JJ; Carr, AM; Jackson, SP; Smerdon, SJ,期刊：Cell, 页码：100-111 , 文章类型： Article，,卷期：2009年139-1]
- The Mre11/Rad50/Nbs1 protein complex plays central enzymatic and signaling roles in the DNA-damage response. Nuclease (Mre11) and scaffolding (Rad50) components of MRN have been extensively characterized, but the molecul...
- Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling
[作者：Paroo, Z; Ye, XC; Chen, S; Liu, QH,期刊：Cell, 页码：112-122 , 文章类型： Article，,卷期：2009年139-1]
- MicroRNAs (miRNAs) govern an expanding number of biological and disease processes. Understanding the mechanisms by which the miRNA pathway is regulated, therefore, represents an important area of investigation. We determ...
- The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation
[作者：Claycomb, JM; Batista, PJ; Pang, KM; Gu, WF; Vasale, JJ; van Wolfswinkel, JC; Chaves, DA; Shirayama, M; Mitani, S; Ketting, RF; Conte, D; Mello, CC,期刊：Cell, 页码：123-134 , 文章类型： Article，,卷期：2009年139-1]
- RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the RNA-dependent RNA polymerase EGO-1, the Dicer-related helicas...
- CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs
[作者：van Wolfswinkel, JC; Claycomb, JM; Batista, PJ; Mello, CC; Berezikov, E; Ketting, RF,期刊：Cell, 页码：135-148 , 文章类型： Article，,卷期：2009年139-1]
- We have studied the function of a conserved germline-specific nucleotidyltransferase protein, CDE-1, in RNAi and chromosome segregation in C. elegans. CDE-1 localizes specifically to mitotic chromosomes in embryos. This ...
- 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
[作者：Zid, BM; Rogers, AN; Katewa, SD; Vargas, MA; Kolipinski, MC; Lu, TA; Benzer, S; Kapahi, P,期刊：Cell, 页码：149-160 , 文章类型： Article，,卷期：2009年139-1]
- Dietary restriction (DR) extends lifespan in multiple species. To examine the mechanisms of lifespan extension upon DR, we assayed genome-wide translational changes in Drosophila. A number of nuclear encoded mitochondria...
- Stringent Specificity in the Construction of a GABAergic Presynaptic Inhibitory Circuit
[作者：Betley, JN; Wright, CVE; Kawaguchi, Y; Erdelyi, F; Szabo, G; Jessell, TM; Kaltschmidt, JA,期刊：Cell, 页码：161-174 , 文章类型： Article，,卷期：2009年139-1]
- GABAergic interneurons are key elements in neural coding, but the mechanisms that assemble inhibitory circuits remain unclear. In the spinal cord, the transfer of sensory signals to motor neurons is filtered by GABAergic...
- Retinal Input Instructs Alignment of Visual Topographic Maps
[作者：Triplett, JW; Owens, MT; Yamada, J; Lemke, G; Cang, JH; Stryker, MP; Feldheim, DA,期刊：Cell, 页码：175-185 , 文章类型： Article，,卷期：2009年139-1]
- Sensory information is represented in the brain in the form of topographic maps, in which neighboring neurons respond to adjacent external stimuli. In the visual system, the superior colliculus receives topographic proje...
- A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells
[作者：Zhang, EE; Liu, AC; Hirota, T; Miraglia, LJ; Welch, G; Pongsawakul, PY; Liu, XZ; Atwood, A; Huss, JW; Janes, J; Su, AI; Hogenesch, JB; Kay, SA,期刊：Cell, 页码：199-210 , 文章类型： Article，,卷期：2009年139-1]
- Two decades of research identified more than a dozen clock genes and defined a biochemical feedback mechanism of circadian oscillator function. To identify additional clock genes and modifiers, we conducted a genome-wide...
- Mechanotransduction by Hair Cells: Models, Molecules, and Mechanisms
[作者：Gillespie, PG; Muller, U,期刊：Cell, 页码：33-44 , 文章类型： Review，,卷期：2009年139-1]
- Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity, detect touch, and sense changes in cell volume and shape. Hair cells ...
- Olfactory Perception: Receptors, Cells, and Circuits
[作者：Su, CY; Menuz, K; Carlson, JR,期刊：Cell, 页码：45-59 , 文章类型： Review，,卷期：2009年139-1]
- Remarkable advances in our understanding of olfactory perception have been made in recent years, including the discovery of new mechanisms of olfactory signaling and new principles of olfactory processing. Here, we discu...
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