- Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
[作者：Kota, J; Chivukula, RR; O'Donnell, KA; Wentzel, EA; Montgomery, CL; Hwang, HW; Chang, TC; Vivekanandan, P; Torbenson, M; Clark, KR; Mendell, JR; Mendell, JT,期刊：Cell, 页码：1005-1017 , 文章类型： Article，,卷期：2009年137-6]
- Therapeutic strategies based on modulation of microRNA (miRNA) activity hold great promise due to the ability of these small RNAs to potently influence cellular behavior. In this study, we investigated the efficacy of a ...
- Retinoblastoma Has Properties of a Cone Precursor Tumor and Depends Upon Cone-Specific MDM2 Signaling
[作者：Xu, XLL; Fang, YQ; Lee, TC; Forrest, D; Gregory-Evans, C; Almeida, D; Liu, AH; Jhanwar, SC; Abramson, DH; Cobrinik, D,期刊：Cell, 页码：1018-1031 , 文章类型： Article，,卷期：2009年137-6]
- Retinoblastomas result from the inactivation of the RB1 gene and the loss of Rb protein, yet the cell type in which Rb suppresses retinoblastoma and the circuitry that underlies the need for Rb are undefined. Here, we sh...
- A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
[作者：Valastyan, S; Reinhardt, F; Benaich, N; Calogrias, D; Szasz, AM; Wang, ZGC; Brock, JE; Richardson, AL; Weinberg, RA,期刊：Cell, 页码：1032-1046 , 文章类型： Article，,卷期：2009年137-6]
- MicroRNAs are well suited to regulate tumor metastasis because of their capacity to coordinately repress numerous target genes, thereby potentially enabling their intervention at multiple steps of the invasion-metastasis...
- Cyfip1 Is a Putative Invasion Suppressor in Epithelial Cancers
[作者：Silva, JM; Ezhkova, E; Silva, J; Heart, S; Castillo, M; Campos, Y; Castro, V; Bonilla, F; Cordon-Cardo, C; Muthuswamy, SK; Powers, S; Fuchs, E; Hannon, GJ,期刊：Cell, 页码：1047-1061 , 文章类型： Article，,卷期：2009年137-6]
- Identification of bona fide tumor suppressors is often challenging because of the large number of genetic alterations present in most human cancers. To evaluate candidate genes present within chromosomal regions recurren...
- Autophagy Suppresses Tumorigenesis through Elimination of p62
[作者：Mathew, R; Karp, CM; Beaudoin, B; Vuong, N; Chen, GH; Chen, HY; Bray, K; Reddy, A; Bhanot, G; Gelinas, C; DiPaola, RS; Karantza-Wadsworth, V; White, E,期刊：Cell, 页码：1062-1075 , 文章类型： Article，,卷期：2009年137-6]
- Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-prone suggesting that autophagy is a tumor-suppression mechanism. While tumor cells utilize autophagy to survive metabol...
- Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation
[作者：Inomata, K; Aoto, T; Binh, NT; Okamoto, N; Tanimura, S; Wakayama, T; Iseki, S; Hara, E; Masunaga, T; Shimizu, H; Nishimura, EK,期刊：Cell, 页码：1088-1099 , 文章类型： Article，,卷期：2009年137-6]
- Somatic stem cell depletion due to the accumulation of DNA damage has been implicated in the appearance of aging-related phenotypes. Hair graying, a typical sign of aging in mammals, is caused by the incomplete maintenan...
- Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-alpha
[作者：He, SD; Wang, L; Miao, L; Wang, T; Du, FH; Zhao, LP; Wang, XD,期刊：Cell, 页码：1100-1111 , 文章类型： Article，,卷期：2009年137-6]
- Smac mimetics induce apoptosis synergistically with TNF-alpha by triggering the formation of a caspase-8-activating complex containing receptor interacting protein kinase-1 (RIPK1). Caspase inhibitors block this form of ...
- Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
[作者：Cho, Y; Challa, S; Moquin, D; Genga, R; Ray, TD; Guildford, M; Chan, FKM,期刊：Cell, 页码：1112-1123 , 文章类型： Article，,卷期：2009年137-6]
- Programmed necrosis is a form of caspase-independent cell death whose molecular regulation is poorly understood. The kinase RIP1 is crucial for programmed necrosis, but also mediates activation of the prosurvival transcr...
- The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis
[作者：Benedito, R; Roca, C; Sorensen, I; Adams, S; Gossler, A; Fruttiger, M; Adams, RH,期刊：Cell, 页码：1124-1135 , 文章类型： Article，,卷期：2009年137-6]
- The Notch pathway is a highly conserved signaling system that controls a diversity of growth, differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial tip cells is inhibited by Notch ...
- Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain
[作者：Scherrer, G; Imamachi, N; Cao, YQ; Contet, C; Mennicken, F; O'Donnell, D; Kieffer, BL; Basbaum, AI,期刊：Cell, 页码：1148-1159 , 文章类型： Article，,卷期：2009年137-6]
- Delta and mu opioid receptors (DORs and MORs) are inhibitory G protein-coupled receptors that reportedly cooperatively regulate the transmission of pain messages by substance P and TRPV1-expressing pain fibers. Using a D...
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