- SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder
[作者：Cantagrel, V; Lefeber, DJ; Ng, BG; Guan, ZQ; Silhavy, JL; Bielas, SL; Lehle, L; Hombauer, H; Adamowicz, M; Swiezewska, E; De Brouwer, AP; Blumel, P; Sykut-Cegielska, J; Houliston, S; Swistun, D; Ali, BR; Dobyns, WB; Babovic-Vuksanovic, D; van Bokhoven, H; Wevers, RA; Raetz, CRH; Freeze, HH; Morava, E; Al-Gazali, L; Gleeson, JG,期刊：Cell, 页码：203-217 , 文章类型： Article，,卷期：2010年142-2]
- N-linked glycosylation is the most frequent modification of secreted and membrane-bound proteins in eukaryotic cells, disruption of which is the basis of the congenital disorders of glycosylation (CDGs). We describe a ne...
- NF1 Is a Tumor Suppressor in Neuroblastoma that Determines Retinoic Acid Response and Disease Outcome
[作者：Holzel, M; Huang, SD; Koster, J; Ora, I; Lakeman, A; Caron, H; Nijkamp, W; Xie, J; Callens, T; Asgharzadeh, S; Seeger, RC; Messiaen, L; Versteeg, R; Bernards, R,期刊：Cell, 页码：218-229 , 文章类型： Article，,卷期：2010年142-2]
- Retinoic acid (RA) induces differentiation of neuroblastoma cells in vitro and is used with variable success to treat aggressive forms of this disease. This variability in clinical response to RA is enigmatic, as no muta...
- TRF2 and Apollo Cooperate with Topoisomerase 2 alpha to Protect Human Telomeres from Replicative Damage
[作者：Ye, J; Lenain, C; Bauwens, S; Rizzo, A; Saint-Leger, A; Poulet, A; Benarroch, D; Magdinier, F; Morere, J; Amiard, S; Verhoeyen, E; Britton, S; Calsou, P; Salles, B; Bizard, A; Nadal, M; Salvati, E; Sabatier, L; Wu, YL; Biroccio, A; Londono-Vallejo, A; Giraud-Panis, MJ; Gilson, E,期刊：Cell, 页码：230-242 , 文章类型： Article，,卷期：2010年142-2]
- Human telomeres are protected from DNA damage by a nucleoprotein complex that includes the repeat-binding factor TRF2. Here, we report that TRF2 regulates the 5' exonuclease activity of its binding partner, Apollo, a mem...
- Essential Regulation of Cell Bioenergetics by Constitutive InsP(3) Receptor Ca2+ Transfer to Mitochondria
[作者：Cardenas, C; Miller, RA; Smith, I; Bui, T; Molgo, J; Muller, M; Vais, H; Cheung, KH; Yang, J; Parker, I; Thompson, CB; Birnbaum, MJ; Hallows, KR; Foskett, JK,期刊：Cell, 页码：270-283 , 文章类型： Article，,卷期：2010年142-2]
- Mechanisms that regulate cellular metabolism are a fundamental requirement of all cells. Most eukaryotic cells rely on aerobic mitochondrial metabolism to generate ATP. Nevertheless, regulation of mitochondrial activity ...
- External Lipid PI3P Mediates Entry of Eukaryotic Pathogen Effectors into Plant and Animal Host Cells
[作者：Kale, SD; Gu, BA; Capelluto, DGS; Dou, DL; Feldman, E; Rumore, A; Arredondo, FD; Hanlon, R; Fudal, I; Rouxel, T; Lawrence, CB; Shan, WX; Tyler, BM,期刊：Cell, 页码：284-295 , 文章类型： Article，,卷期：2010年142-2]
- Pathogens of plants and animals produce effector proteins that are transferred into the cytoplasm of host cells to suppress host defenses. One type of plant pathogens, oomycetes, produces effector proteins with N-termina...
- Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism
[作者：Ferron, M; Wei, JW; Yoshizawa, T; Del Fattore, A; DePinho, RA; Teti, A; Ducy, P; Karsenty, G,期刊：Cell, 页码：296-308 , 文章类型： Article，,卷期：2010年142-2]
- The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose meta...
- Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
[作者：Fulzele, K; Riddle, RC; DiGirolamo, DJ; Cao, XM; Wan, C; Chen, DQ; Faugere, MC; Aja, S; Hussain, MA; Bruning, JC; Clemens, TL,期刊：Cell, 页码：309-319 , 文章类型： Article，,卷期：2010年142-2]
- Global energy balance in mammals is controlled by the actions of circulating hormones that coordinate fuel production and utilization in metabolically active tissues. Bone-derived osteocalcin, in its undercarboxylated, h...
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