- Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer
[作者：Schaeffer, EM; Marchionni, L; Huang, Z; Simons, B; Blackman, A; Yu, W; Parmigiani, G; Berman, DM,期刊：Oncogene, 页码：7180-7191 , 文章类型： Article，,卷期：2008年27-57]
- Cancer cells differentiate along specific lineages that largely determine their clinical and biologic behavior. Distinct cancer phenotypes from different cells and organs likely result from unique gene expression reperto...
- RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin
[作者：Kurisetty, VV; Johnston, PG; Johnston, N; Erwin, P; Crowe, P; Fernig, DG; Campbell, FC; Anderson, IP; Rudland, PS; El-Tanani, MK,期刊：Oncogene, 页码：7139-7149 , 文章类型： Article，,卷期：2008年27-57]
- Osteopontin (OPN) is a phosphorylated glycoprotein that binds to alpha v-containing integrins and is important in malignant transformation and cancer. Previously, we have utilized suppressive subtractive hybridization be...
- Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM
[作者：Wickenden, JA; Jin, H; Johnson, M; Gillings, AS; Newson, C; Austin, M; Chell, SD; Balmanno, K; Pritchard, CA; Cook, SJ,期刊：Oncogene, 页码：7150-7161 , 文章类型： Article，,卷期：2008年27-57]
- The RAF-mitogen-activated protein kinase kinase 1/2 extracellular signal-regulated kinase 1/2 (RAF-MEK1/2-ERK1/2) pathway is activated in many human tumours and can protect cells against growth factor deprivation; howeve...
- Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma
[作者：Ohtani, Y; Harada, T; Funasaka, Y; Nakao, K; Takahara, C; Abdel-Daim, M; Sakai, N; Saito, N; Nishigori, C; Aiba, A,期刊：Oncogene, 页码：7162-7170 , 文章类型： Article，,卷期：2008年27-57]
- Ectopic expression of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse melanocytes induces melanoma formation. Although requirement of mGluR1 for development of melanoma in the initial stage has been demonstra...
- Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver
[作者：Gray, MJ; Dallas, NA; Van Buren, G; Xia, L; Yang, AD; Somcio, RJ; Gaur, P; Mangala, LS; Vivas-Mejia, PE; Fan, F; Sanguino, AM; Gallick, GE; Lopez-Berestein, G; Sood, AK; Ellis, LM,期刊：Oncogene, 页码：7192-7200 , 文章类型： Article，,卷期：2008年27-57]
- During development inhibitor of DNA-bind-2 (Id2) regulates proliferation and differentiation. Id2 expression has been detected in cancer cells, yet its cellular function and validity as a therapeutic target remains large...
- Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer
[作者：Rodriguez-Gonzalez, A; Cyrus, K; Salcius, M; Kim, K; Crews, CM; Deshaies, RJ; Sakamoto, KM,期刊：Oncogene, 页码：7201-7211 , 文章类型： Article，,卷期：2008年27-57]
- Proteolysis targeting chimeric molecules (Protacs) target proteins for destruction by exploiting the ubiquitin-dependent proteolytic system of eukaryotic cells. We designed two Protacs that contain the peptide 'degron' f...
- Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling
[作者：Ischenko, I; Camaj, P; Seeliger, H; Kleespies, A; Guba, M; De Toni, EN; Schwarz, B; Graeb, C; Eichhorn, ME; Jauch, KW; Bruns, CJ,期刊：Oncogene, 页码：7212-7222 , 文章类型： Article，,卷期：2008年27-57]
- Resistance to chemotherapy is believed to be a major cause of treatment failure in pancreatic cancer. Thus, it is necessary to explore alternative therapeutic modalities to overcome drug resistance in pancreatic cancer t...
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