- Functional Role of PPAR delta in Corneal Epithelial Wound Healing
[作者:Nakamura, Y; Nakamura, T; Tarui, T; Inoue, J; Kinoshita, S,期刊:American Journal of Pathology, 页码:583-598 , 文章类型: Article,,卷期:2012年180-2]
- The peroxisome proliferator-activated receptor (PPAR) delta is involved in tissue repair. In this study, we investigated the functional role of PPAR delta in corneal epithelial wound healing. In an in vivo corneal wound-...
- ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells
[作者:Liu, XF; Ory, V; Chapman, S; Yuan, H; Albanese, C; Kallakury, B; Timofeeva, OA; Nealon, C; Dakic, A; Simic, V; Haddad, BR; Rhim, JS; Dritschilo, A; Riegel, A; McBride, A; Schlegel, R,期刊:American Journal of Pathology, 页码:599-607 , 文章类型: Article,,卷期:2012年180-2]
- We demonstrate that a Rho kinase inhibitor (Y-27632), in combination with fibroblast feeder cells, induces normal and tumor epithelial cells from many tissues to proliferate indefinitely in vitro, without transduction of...
- Paracellular versus Transcellular Intestinal Permeability to Gliadin Peptides in Active Celiac Disease
[作者:Menard, S; Lebreton, C; Schumann, M; Matysiak-Budnik, T; Dugave, C; Bouhnik, Y; Malamut, G; Cellier, C; Allez, M; Crenn, P; Schulzke, JD; Cerf-Bensussan, N; Heyman, M,期刊:American Journal of Pathology, 页码:608-615 , 文章类型: Article,,卷期:2012年180-2]
- The intestinal permeability of undegraded alpha 9-gliadin peptide 31-49 (p31-49) and 33-mer gliadin peptides is increased in active celiac disease. Two distinct transport pathways have been proposed: paracellular leakage...
- Intermediate Methylation Epigenotype and Its Correlation to KRAS Mutation in Conventional Colorectal Adenoma
[作者:Yagi, K; Takahashi, H; Akagi, K; Matsusaka, K; Seto, Y; Aburatani, H; Nakajima, A; Kaneda, A,期刊:American Journal of Pathology, 页码:616-625 , 文章类型: Article,,卷期:2012年180-2]
- A subset of colorectal cancer shows significant accumulation of aberrant promoter methylation. Previously, we developed two groups of methylation markers that classified colorectal cancer into three epigenotypes: i) high...
- Probiotic Bacteria Induce Maturation of Intestinal Claudin 3 Expression and Barrier Function
[作者:Patel, RM; Myers, LS; Kurundkar, AR; Maheshwari, A; Nusrat, A; Lin, PW,期刊:American Journal of Pathology, 页码:626-635 , 文章类型: Article,,卷期:2012年180-2]
- An immature intestinal epithelial barrier may predispose infants and children to many intestinal inflammatory diseases, such as infectious enteritis, inflammatory bowel disease, and necrotizing enterocolitis. Understandi...
- Constitutive TL1A Expression under Colitogenic Conditions Modulates the Severity and Location of Gut Mucosal Inflammation and Induces Fibrostenosis
[作者:Barrett, R; Zhang, XL; Koon, HW; Vu, M; Chang, JY; Yeager, N; Nguyen, MA; Michelsen, KS; Berel, D; Pothoulakis, C; Targan, SR; Shih, DQ,期刊:American Journal of Pathology, 页码:636-649 , 文章类型: Article,,卷期:2012年180-2]
- Intestinal fibrostenosis is a hallmark of severe Crohn's disease and can lead to multiple surgeries. Patients with certain TNFSF15 variants overexpress TL1A. The aim of this study was to determine the effect of TL1A over...
- Modulation of IFN-gamma Receptor 1 Expression by AP-2 alpha Influences IFN-gamma Sensitivity of Cancer Cells
[作者:Chen, CG; Guo, L; Shi, M; Hu, M; Hu, MR; Yu, M; Wang, TY; Song, L; Shen, BF; Qian, L; Guo, N,期刊:American Journal of Pathology, 页码:661-671 , 文章类型: Article,,卷期:2012年180-2]
- Interferon (IFN)-gamma plays crucial roles in regulating both innate and adaptive immunity. The existence of IFN-gamma receptor 1 (IFNGR1) molecules on the cell surface is a prerequisite to the initiation of IFN-gamma si...
- Therapeutic Dosing of Fingolimod (FTY720) Prevents Cell Infiltration, Rapidly Suppresses Ocular Inflammation, and Maintains the Blood-Ocular Barrier
[作者:Copland, DA; Liu, J; Schewitz-Bowers, LP; Brinkmann, V; Anderson, K; Nicholson, LB; Dick, AD,期刊:American Journal of Pathology, 页码:672-681 , 文章类型: Article,,卷期:2012年180-2]
- Fingolimod (FTY720) is an FDA-approved therapeutic drug with efficacy demonstrated in experimental models of multiple sclerosis and in phase III human multiple sclerosis trials. Fingolimod prevents T-cell migration to in...
- Adiponectin and Its Globular Fragment Differentially Modulate the Oxidative Burst of Primary Human Phagocytes
[作者:Chedid, P; Hurtado-Nedelec, M; Marion-Gaber, B; Bournier, O; Hayem, G; Gougerot-Pocidalo, MA; Frystyk, J; Flyvbjerg, A; El Benna, J; Marie, JC,期刊:American Journal of Pathology, 页码:682-692 , 文章类型: Article,,卷期:2012年180-2]
- Adiponectin (Acrp30) belongs to the family of C1q/tumor necrosis factor alpha (TNF alpha)-related proteins. Acrp30 circulates as multimers of high, middle, and low molecular weight. In this study, we detected Acrp30 and ...
- Placental Syndecan Expression Is Altered in Human Idiopathic Fetal Growth Restriction
[作者:Chui, A; Zainuddin, N; Rajaraman, G; Murthi, P; Brennecke, SP; Ignjatovic, V; Monagle, PT; Said, JM,期刊:American Journal of Pathology, 页码:693-702 , 文章类型: Article,,卷期:2012年180-2]
- Pregnancy represents a hypercoagulable state characterized by increased thrombin generation. However, placentas from fetal growth restriction (FGR) pregnancies are characterized by increased fibrin deposition and thrombi...
- Increased Accumulation of Extracellular Thrombospondin-2 Due to Low Degradation Activity Stimulates Type I Collagen Expression in Scleroderma Fibroblasts
[作者:Kajihara, I; Jinnin, M; Yamane, K; Makino, T; Honda, N; Igata, T; Masuguchi, S; Fukushima, S; Okamoto, Y; Hasegawa, M; Fujimoto, M; Ihn, H,期刊:American Journal of Pathology, 页码:703-714 , 文章类型: Article,,卷期:2012年180-2]
- The aim of the present study was to determine the expression and role of thrombospondin-2 (TSP-2) in systemic sclerosis (SSc). Both TSP-2 mRNA levels and protein synthesis in cell lysates were significantly lower in cult...
- Insulin Induces Production of New Elastin in Cultures of Human Aortic Smooth Muscle Cells
[作者:Shi, JY; Wang, A; Sen, S; Wang, YT; Kim, HJ; Mitts, TF; Hinek, A,期刊:American Journal of Pathology, 页码:715-726 , 文章类型: Article,,卷期:2012年180-2]
- Diabetes mellitus accelerates atherosclerotic progression, peripheral angiopathy development, and arterial hypertension, all of which are associated with elastic fiber disease. However, the potential mechanistic links be...
- Chop (Ddit3) Is Essential for D469del-COMP Retention and Cell Death in Chondrocytes in an Inducible Transgenic Mouse Model of Pseudoachondroplasia
[作者:Posey, KL; Coustry, F; Veerisetty, AC; Liu, PM; Alcorn, JL; Hecht, JT,期刊:American Journal of Pathology, 页码:727-737 , 文章类型: Article,,卷期:2012年180-2]
- Cartilage oligomeric matrix protein (COMP), a secreted glycoprotein synthesized by chondrocytes, regulates proliferation and type II collagen assembly. Mutations in the COMP gene cause pseudoachondroplasia and multiple e...
- Urocortins Improve Dystrophic Skeletal Muscle Structure and Function through Both PKA- and Epac-Dependent Pathways
[作者:Reutenauer-Patte, J; Boittin, FX; Patthey-Vuadens, O; Ruegg, UT; Dorchies, OM,期刊:American Journal of Pathology, 页码:749-762 , 文章类型: Article,,卷期:2012年180-2]
- In Duchenne muscular dystrophy, the absence of dystrophin causes progressive muscle wasting and premature death. Excessive calcium influx is thought to initiate the pathogenic cascade, resulting in muscle cell death. Uro...
|