- Inhibition of gamma-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma
[作者：Plentz, R; Park, JS; Rhim, AD; Abravanel, D; Hezel, AF; Sharma, SV; Gurumurthy, S; Deshpande, V; Kenific, C; Settleman, J; Majumder, PK; Stanger, BZ; Bardeesy, N,期刊：Gastroenterology, 页码：1741-1749 , 文章类型： Article，,卷期：2009年136-5]
- Background & Aim: The Notch signaling pathway is required for the expansion of undifferentiated pancreatic progenitor cells during embryonic development and has been implicated in the progression of pancreatic ductal ade...
- Statin Use and the Risk of Cholecystectomy in Women
[作者：Tsai, CJ; Leitzmann, MF; Willett, WC; Giovannucci, EL,期刊：Gastroenterology, 页码：1593-1600 , 文章类型： Article，,卷期：2009年136-5]
- Background & Aims: Statins can reduce biliary cholesterol secretion independently of their ability to inhibit cholesterol synthesis. Statins also prevent the formation of gallstones in animal studies, although the effect...
- Decreasing Time-Trends of Colorectal Cancer in a Large Cohort of Patients With Inflammatory Bowel Disease
[作者：Soderlund, S; Brandt, L; Lapidus, A; Karlen, P; Brostrom, O; Lofberg, R; Ekbom, A; Askling, J,期刊：Gastroenterology, 页码：1561-1567 , 文章类型： Article，,卷期：2009年136-5]
- Background & Aims: Inflammatory bowel disease (IBD) is a risk factor for colorectal cancer (CRC). There have been marked changes in the management and treatment of IBD over the past decades, but little is known about how...
- Tests of Gastric Neuromuscular Function
[作者：Parkman, HP; Jones, MP,期刊：Gastroenterology, 页码：1526-1543 , 文章类型： Review，,卷期：2009年136-5]
- Tests of gastric neuromuscular function are used to evaluate patients with symptoms referable to the upper digestive tract. These symptoms can be associated with alterations in the rates of gastric emptying, impaired acc...
- The Absence of LPA(2) Attenuates Tumor Formation in an Experimental Model of Colitis-Associated Cancer
[作者：Lin, SB; Wang, DS; Iyer, S; Ghaleb, AM; Shim, H; Yang, VW; Chun, J; Yun, CC,期刊：Gastroenterology, 页码：1711-1720 , 文章类型： Article，,卷期：2009年136-5]
- Background & Aims: Chronic inflammation is a risk factor for colon cancer (CC). Lysophosphatidic acid (LPA), a naturally produced phospholipid, mediates multiple effects that are vital to disease process, including infla...
- Abdominal Distention Results From Caudo-ventral Redistribution of Contents
[作者：Accarino, A; Perez, F; Azpiroz, F; Quiroga, S; Malagelada, JR,期刊：Gastroenterology, 页码：1544-1551 , 文章类型： Article，,卷期：2009年136-5]
- Background & Aims: Abdominal bloating is a frequent symptom in various categories of patients; however, its origin is unclear. Our aim was to establish the mechanisms of abdominal bloating. Methods: The study evaluated 5...
- Obesity and the Microbiota
[作者：Tilg, H; Moschen, AR; Kaser, A,期刊：Gastroenterology, 页码：1476-1483 , 文章类型： Review，,卷期：2009年136-5]
- The enormous number and diversity of microorganisms in the human intestine contribute a diverse sec of functions, which complement the host for important features such as digestion of complex carbohydrates. Convventional...
- Heat Shock Protein 70 Inhibits Apoptosis in Cancer Cells Through Simultaneous and Independent Mechanisms
[作者：Dudeja, V; Mujumdar, N; Phillips, P; Chugh, R; Borja-Cacho, D; Dawra, RK; Vickers, SM; Saluja, AK,期刊：Gastroenterology, 页码：1772-1782 , 文章类型： Article，,卷期：2009年136-5]
Background & Aims: Heat shock proteins (HSPs) are highly conserved and serve a multitude of functions that mediate cell survival. HSP70, the only inducible form of the 70-kilodalton subfamily of HSPs, is overexpre...
- Hepatocyte Transplantation-Induced Liver Inflammation Is Driven by Cytokines-Chemokines Associated With Neutrophils and Kupffer Cells
[作者：Krohn, N; Kapoor, S; Enami, Y; Follenzi, A; Bandi, S; Joseph, B; Gupta, S,期刊：Gastroenterology, 页码：1806-1817 , 文章类型： Article，,卷期：2009年136-5]
- Background & Aims: Hepatocyte transplantation-induced liver inflammation impairs cell engraftment. We defined whether proinflammatory cytokines and chemokines played roles in regulation of hepatocyte engraftment in the l...
- Interaction of Cyclooxygenase-2 Variants and Smoking in Pancreatic Cancer: A Possible Role of Nucleophosmin
[作者：Zhao, D; Xu, DK; Zhang, XM; Wang, L; Tan, W; Guo, YL; Yu, DK; Li, H; Zhao, P; Lin, DX,期刊：Gastroenterology, 页码：1659-1668 , 文章类型： Article，,卷期：2009年136-5]
- Background & Aims: Overexpression of cyclooxygenase-2 (COX-2) is implicated in cancer development. This study examined the functional relevance of genetic polymorphisms in the COX-2 promoter and evaluated their associati...
- Heritability of Nonalcoholic Fatty Liver Disease
[作者：Schwimmer, JB; Celedon, MA; Lavine, JE; Salem, R; Campbell, N; Schork, NJ; Shiehmorteza, M; Yokoo, T; Chavez, A; Middleton, MS; Sirlin, CB,期刊：Gastroenterology, 页码：1585-1592 , 文章类型： Article，,卷期：2009年136-5]
- Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. The etiology is believed to be multifactorial with a substantial genetic component; however, the ...
- A 28-Year Study of the Course of Hepatitis Delta Infection: A Risk Factor for Cirrhosis and Hepatocellular Carcinoma
[作者：Romeo, R; Del Ninno, E; Rumi, M; Russo, A; Sangiovanni, A; De Franchis, R; Ronchi, G; Colombo, M,期刊：Gastroenterology, 页码：1629-1638 , 文章类型： Article，,卷期：2009年136-5]
- Background & Aims: Chronic infection with hepatitis Delta virus (HDV) is a risk factor for cirrhosis and hepatocellular carcinoma (HCC); predictors of disease outcome are, however, poorly defined. We tracked the course o...
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