- Calreticulin enhances porcine wound repair by diverse biological effects
[作者:Nanney, LB; Woodrell, CD; Greives, MR; Cardwell, NL; Pollins, AC; Bancroft, TA; Chesser, A; Michalak, M; Rahman, M; Siebert, JW; Gold, LI,期刊:American Journal of Pathology, 页码:610-630 , 文章类型: Article,,卷期:2008年173-3]
- Extracellular functions of the endoplasmic reticulum chaperone protein calreticulin (CRT) are emerging. Here we show novel roles for exogenous CRT in both cutaneous wound heating and diverse processes associated with rep...
- Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration
[作者:Shweke, N; Boulos, N; Jouanneau, C; Vandermeersch, S; Melino, G; Dussaule, JC; Chatziantoniou, C; Ronco, P; Boffa, JJ,期刊:American Journal of Pathology, 页码:631-642 , 文章类型: Article,,卷期:2008年173-3]
- Renal fibrosis is defined by the exaggerated accumulation of extracellular matrix proteins. Tissue transglutaminase (TG2) modifies the stability of extracellular matrix proteins and renders the extracellular matrix resis...
- ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair
[作者:Yates, CC; Whaley, D; Y-Chen, A; Kulesekaran, P; Hebda, PA; Wells, A,期刊:American Journal of Pathology, 页码:643-652 , 文章类型: Article,,卷期:2008年173-3]
- In skin wounds, the chemokine CXCR3 receptor appears to play a key role in coordinating the switch from regeneration of the ontogenically distinct mesenchymal and epithelial compartments toward maturation. However, becau...
- Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion
[作者:Nakashima, A; Shiozaki, A; Myojo, S; Ito, M; Tatematsu, M; Sakai, M; Takamori, Y; Ogawa, K; Nagata, K; Saito, S,期刊:American Journal of Pathology, 页码:653-664 , 文章类型: Article,,卷期:2008年173-3]
- Immune changes are known to occur in recurrent spontaneous abortion, but it is unclear whether either maternal natural killer (NK) cells or T cells attack fetus-derived trophoblasts. To clarify the immunological causes o...
- Koilocytosis - A cooperative interaction between the human papillomavirus E5 and E6 oncoproteins
[作者:Krawczyk, E; Suprynowicz, FA; Liu, XF; Dai, YH; Hartmann, DP; Hanover, J; Schlegel, R,期刊:American Journal of Pathology, 页码:682-688 , 文章类型: Article,,卷期:2008年173-3]
- A long-recognized, pathognomonic feature of human papillomavirus (HPV) infection is the appearance of halo or koilocytotic cells in the differentiated layers of the squamous epithelium. These koilocytes are squamous epit...
- Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia - Implications for the pathogenesis of psoriasis
[作者:Elias, PM; Arbiser, J; Brown, BE; Rossiter, H; Man, MQ; Cerimele, F; Crumrine, D; Gunathilake, R; Choi, EH; Uchida, Y; Tschachler, E; Feingold, KR,期刊:American Journal of Pathology, 页码:689-699 , 文章类型: Article,,卷期:2008年173-3]
- Primary abnormalities in permeability barrier function appear to underlie atopic dermatitis and epidermal trauma; a concomitant barrier dysfunction could also drive other inflammatory dermatoses, including psoriasis. Cen...
- Endometrial-peritoneal interactions during endometriotic lesion establishment
[作者:Hull, ML; Escareno, CR; Godsland, JM; Doig, JR; Johnson, CM; Phillips, SC; Smith, SK; Tavare, S; Print, CG; Charnock-Jones, DS,期刊:American Journal of Pathology, 页码:700-715 , 文章类型: Article,,卷期:2008年173-3]
- The pathophysiology of endometriosis remains unclear but involves a complex interaction between ectopic endometrium and host peritoneal tissues. We hypothesized that disruption of this interaction would suppress endometr...
- Enhanced nitrosative stress during Trypanosoma cruzi infection causes nitrotyrosine modification of host proteins - Implications in Chagas' disease
[作者:Dhiman, M; Nakayasu, ES; Madaiah, YH; Reynolds, BK; Wen, JJ; Almeida, IC; Garg, NJ,期刊:American Journal of Pathology, 页码:728-740 , 文章类型: Article,,卷期:2008年173-3]
- Oxidative/nitrosative stress may he important in the pathology of Chagas' disease. Experimental animals infected by Trypanosoma cruzi showed an early rise in myocardial and peripheral protein-3-nitrotyrosine (3NT) and pr...
- CCR2 receptor is essential to activate microbicidal mechanisms to control Toxoplasma gondii infection in the central nervous system
[作者:Benevides, L; Milanezi, CM; Yamauchi, LM; Benjamim, CF; Silva, JS; Silva, NM,期刊:American Journal of Pathology, 页码:741-751 , 文章类型: Article,,卷期:2008年173-3]
- Chemokines comprise a structurally related family of cytokines that regulate leukocyte trafficking. Because infection with Toxoplasma gondii can induce an important inflammatory reaction that, if left uncontrolled, can l...
- Hedgehog signaling, keratin 6 induction, and sebaceous gland morphogenesis - Implications for pachyonychia congenita and related conditions
[作者:Gu, LH; Coulombe, PA,期刊:American Journal of Pathology, 页码:752-761 , 文章类型: Article,,卷期:2008年173-3]
- Keratins 6a and b (K6a, K6b) belong to a subset of keratin genes with constitutive expression in epithelial appendages, and inducible expression in additional epithelia, when subjected to environmental challenges or dise...
- Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease
[作者:Paulson, JB; Ramsden, M; Forster, C; Sherman, MA; McGowan, E; Ashe, KH,期刊:American Journal of Pathology, 页码:762-772 , 文章类型: Article,,卷期:2008年173-3]
- Transgenic mouse models that independently express mutations in amyloid precursor protein (APP) and tau have proven useful for the study of the neurological consequences of amyloid-beta (A beta) plaque and neurofibrillar...
- Dlx5, a positive regulator of osteoblastogenesis, is essential for osteoblast-osteoclast coupling
[作者:Samee, N; Geoffroy, V; Marty, C; Schiltz, C; Vieux-Rochas, M; Levi, G; de Vernejoul, MC,期刊:American Journal of Pathology, 页码:773-780 , 文章类型: Article,,卷期:2008年173-3]
- The homeodomain protein Dlx5 is an activator of Runx2 (a key regulator of osteogenesis) and is thought to be an important regulator of bone formation. At present, however, the perinatal lethality of Dlx5-null mice has ha...
- Soluble forms of the Notch ligands Delta1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distinct phenotypes
[作者:Urs, S; Roudabush, A; O'Neill, CF; Pinz, I; Prudovsky, I; Kacer, D; Tang, Y; Liaw, L; Small, D,期刊:American Journal of Pathology, 页码:865-878 , 文章类型: Article,,卷期:2008年173-3]
- We previously found that soluble forms of the Notch ligands Jagged1 and Delta1 induced fibroblast growth factor receptor-dependent cell transformation in NIH3T3 fibroblasts. However, the phenotypes of these lines differe...
- Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis
[作者:Krady, MM; Zeng, JM; Yu, J; MacLauchlan, S; Skokos, EA; Tian, WM; Bornstein, P; Sessa, WC; Kyriakides, TR,期刊:American Journal of Pathology, 页码:879-891 , 文章类型: Article,,卷期:2008年173-3]
- Thrombospondin 2 (TSP2) can Inhibit angiogenesis in vitro by limiting proliferation and inducing apoptosis of endothelial cells (ECs). TSP2 can also modulate the extracellular levels of gelatinases (matrix metalloproteas...
- Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts
[作者:Motohashi, N; Uezumi, A; Yada, E; Fukada, SI; Fukushima, K; Imaizumi, K; Miyagoe-Suzuki, Y; Takeda, S,期刊:American Journal of Pathology, 页码:781-791 , 文章类型: Article,,卷期:2008年173-3]
- CD31(-) CD45(-) side population (SP) cells are a minor SP subfraction that have mesenchymal stem cell-like properties in uninjured skeletal muscle but that can expand on muscle injury. To clarify the role of these SP cel...
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