- Gisplatin-mediated impairment of mitochondrial DNA metabolism inversely correlates with glutathione levels
[作者:Garrido, N; Perez-Martos, A; Faro, M; Lou-Bonafonte, JM; Fernandez-Silva, P; Lopez-Perez, MJ; Montoya, J; Enriquez, JA,期刊:Biochemical Journal, 页码:93-102 , 文章类型: Article,,卷期:2008年414-1]
- Cisplatin accumulates in mitochondria, which are a major target for this drug in cancer cells. Thus alterations in mitochondrial function have been implicated in cancer cell resistance to chemotherapeutic agents. Moreove...
- Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells
[作者:Raffalli-Mathieu, F; Orre, C; Stridsberg, M; Edalat, MH; Mannervik, B,期刊:Biochemical Journal, 页码:103-109 , 文章类型: Article,,卷期:2008年414-1]
- hGSTA3-3 (human Alpha-class glutathione transferase 3-3) efficiently catalyses steroid Delta(5)-Delta(4) double-bond isomerization in vitro, using glutathione as a cofactor. This chemical transformation is an obligatory ...
- Heat shock and ethanol stress provoke distinctly different responses in 3 '-processing and nuclear export of HSP mRNA in Saccharomyces cerevisiae
[作者:Izawa, S; Kita, T; Ikeda, K; Inoue, Y,期刊:Biochemical Journal, 页码:111-119 , 文章类型: Article,,卷期:2008年414-1]
- Under conditions of hear shock at 42 degrees C, mRNAs of HSP (heat shock protein) genes are exported out of the nucleus, whereas bulk poly(A)(+) (polyadenylated) mRNA shows a nuclear accumulation in Saccharomyces cerevis...
- Cloning and characterization of dominant negative splice variants of the human histamine H-4 receptor
[作者:van Rijn, RM; van Marle, A; Chazot, PL; Langemeijer, E; Qin, Y; Shenton, FC; Lim, HD; Zuiderveld, OP; Sansuk, K; Dy, M; Smit, MJ; Tensen, CP; Bakker, RA; Leurs, R,期刊:Biochemical Journal, 页码:121-131 , 文章类型: Article,,卷期:2008年414-1]
- The H4R (histamine H-4 receptor) is the latest identified member of the histamine receptor subfamily of GPCRs (G-protein-coupled receptors) with potential functional implications in inflammatory diseases and cancer. The ...
- Probing structure-activity relationships in bactericidal peptide beta pep-25
[作者:Dings, RPM; Haseman, JR; Mayo, KH,期刊:Biochemical Journal, 页码:143-150 , 文章类型: Article,,卷期:2008年414-1]
- Cationic peptides, known to disrupt bacterial membranes, are being developed as promising agents for therapeutic intervention against infections disease. In the present study, we investigate structure-activity relationsh...
- Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila
[作者:Bebrone, C; Anne, C; Kerff, F; Garau, G; De Vriendt, K; Lantin, R; Devreese, B; Van Beeumen, J; Dideberg, O; Frere, JM; Galleni, M,期刊:Biochemical Journal, 页码:151-159 , 文章类型: Article,,卷期:2008年414-1]
- The subclass B2 CphA (Carbapenemase hydrolysing Aeromonas) beta-lactamase from Aeromonas hydrophila is a Zn2+-containing enzyme that specifically hydrolyses carbapenems. In an effort to evaluate residues potentially invo...
- Regulation of gene expression by hypoxia
[作者:Kenneth, NS; Rocha, S,期刊:Biochemical Journal, 页码:19-29 , 文章类型: Review,,卷期:2008年414-1]
- Hypoxia induces profound changes in the cellular gene expression profile. The discovery of a major transcription factor family activated by hypoxia, HIF (hypoxia-inducible factor), and the factors that contribute to HIF ...
- Sphingomyelin synthases regulate production of diacylglycerol at the Golgi
[作者:Villani, M; Subathra, M; Im, YB; Choi, Y; Signorelli, P; Del Poeta, M; Luberto, C,期刊:Biochemical Journal, 页码:31-41 , 文章类型: Article,,卷期:2008年414-1]
- SMS [SM (sphingomyelin) synthase] is a class of enzymes that produces SM by transferring a phosphocholine moiety on to ceramide. PC (phosphatidylcholine) is believed to be the phosphocholine donor of the reaction with co...
- Molecular control of the glucan synthase-like protein NaGSL1 and callose synthesis during growth of Nicotiana alata pollen tubes
[作者:Brownfield, L; Wilson, S; Newbigin, E; Bacic, A; Read, S,期刊:Biochemical Journal, 页码:43-52 , 文章类型: Article,,卷期:2008年414-1]
- The protein NaGSL1 (Nicotiona alata glucan synthase-like 1) is implicated in the synthesis of callose, the 1,3-beta-glucan that is the major polysaccharide in the walls of N. alata (flowering tobacco) pollen tubes. Here ...
- Plant plasma membrane water channels conduct the signalling molecule H2O2
[作者:Dynowski, M; Schaaf, G; Loque, D; Moran, O; Ludewig, U,期刊:Biochemical Journal, 页码:53-61 , 文章类型: Article,,卷期:2008年414-1]
- H2O2 is a relatively long-lived reactive oxygen species that signals between cells and organisms. H2O2 signalling in plants is essential for response to stress, defence against pathogeris and the regulation of programmed...
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