- Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase
[作者:Hurtado-Guerrero, R; Raimi, OG; Min, J; Zeng, H; Vallius, L; Shepherd, S; Ibrahim, AFM; Wu, H; Plotnikov, AN; van Aalten, DMF,期刊:Biochemical Journal, 页码:217-223 , 文章类型: Article,,卷期:2008年415-2]
- Aspergillus fumigatus is the causative agent of aspergillosis, a frequently invasive colonization of the lungs of immuno-compromised patients. GNA1 (D-glucosamine-6-phosphate N-acetyltransferase) catalyses the acetylatio...
- Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell
[作者:Riera, A; Ahuatzi, D; Herrero, P; Garcia-Gimeno, MA; Sanz, P; Moreno, F,期刊:Biochemical Journal, 页码:233-239 , 文章类型: Article,,卷期:2008年415-2]
- Human GK(beta) (pancreatic beta-cell glucokinase) is the main glucose-phosphorylating enzyme in pancreatic beta-cells. It shares several structural, catalytic and regulatory properties with Hxk2 (hexokinase 2) from Sacch...
- Adaptor protein Lnk associates with Tyr(568) in c-Kit
[作者:Gueller, S; Gery, S; Nowak, V; Liu, LQ; Serve, H; Koeffler, HP,期刊:Biochemical Journal, 页码:241-245 , 文章类型: Article,,卷期:2008年415-2]
- The adaptor protein Lnk is expressed in haemopoietic cells and plays a critical role in haemopoiesis. Animal model Studies demonstrated that Lnk acts as a broad inhibitor of signalling pathways in haemopoietic lineages. ...
- A novel protein phosphatase indirectly regulates phytochrome-interacting factor 3 via phytochrome
[作者:Phee, BK; Kim, JI; Shin, DH; Yoo, J; Park, KJ; Han, YJ; Kwon, YK; Cho, MH; Jeon, JS; Bhoo, SH; Hahn, TR,期刊:Biochemical Journal, 页码:247-255 , 文章类型: Article,,卷期:2008年415-2]
- Light signal transduction in plants involves an intricate series of pathways which is finely regulated by interactions between specific signalling proteins, as well as by protein modifications Such as phosphorylation and...
- Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase
[作者:Schubert, HL; Rose, RS; Leech, HK; Brindley, AA; Hill, CR; Rigby, SEJ; Warren, MJ,期刊:Biochemical Journal, 页码:257-263 , 文章类型: Article,,卷期:2008年415-2]
- In Bacillus megaterium, the synthesis of vitamin B-12 (cobalamin) and sirohaem diverges at sirohydrochlorin along the branched modified tetrapyrrole biosynthetic pathway. This key intermediate is made by the action of Si...
- Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus
[作者:Tkachuk, N; Kiyan, J; Tkachuk, S; Kiyan, R; Shushakova, N; Haller, H; Dumler, I,期刊:Biochemical Journal, 页码:265-273 , 文章类型: Article,,卷期:2008年415-2]
- Deregulated apoptosis of MCs (mesangial cells) is associated with a number of kidney diseases including end-stage diabetic nephropathy. Cell death by apoptosis is a tightly orchestrated event, whose mechanisms are not co...
- How do surfactants and DTT affect the size, dynamics, activity and growth of soluble lysozyme aggregates?
[作者:Kumar, S; Ravi, VK; Swaminathan, R,期刊:Biochemical Journal, 页码:275-288 , 文章类型: Article,,卷期:2008年415-2]
- The early intermediates in the protein aggregation pathway, the elusive soluble aggregates, play a pivotal role in growth and maturation of ordered aggregates Such as amyloid fibrils. Blocking the growth of soluble oligo...
- Identification and characterization of FUS/TLS as a new target of ATM
[作者:Gardiner, M; Toth, R; Vandermoere, F; Morrice, NA; Rouse, J,期刊:Biochemical Journal, 页码:297-307 , 文章类型: Article,,卷期:2008年415-2]
- ATM (ataxia-telangiectasia mutated), ATR (ATM- and Rad3-related) and DNA-PK (DNA-dependent protein kinase), important regulators of genome stability, belong to the PIKK (phosphoinositide 3-kinase-like kinase) family of p...
- Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation in Penicillium chrysogenum
[作者:Garcia-Estrada, C; Ullan, RV; Velasco-Conde, T; Godio, RP; Teijeira, F; Vaca, I; Feltrer, R; Kosalkova, K; Mauriz, E; Martin, JF,期刊:Biochemical Journal, 页码:317-324 , 文章类型: Article,,卷期:2008年415-2]
- NRPSs (non-ribosomal peptide synthetases) and PKSs (polyketide synthases) require post-translational phosphopantetheinylation to become active. This reaction is catalysed by a PPTase (4'-phosphopantetheinyl transferase)....
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