- Glucose-Dependent Insulinotropic Polypeptide A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans
[作者:Christensen, M; Vedtofte, L; Holst, JJ; Vilsboll, T; Knop, FK,期刊:Diabetes, 页码:3103-3109 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-To evaluate the glucose dependency of glucose-dependent insulinotropic polypeptide (GIP) effects on insulin and glucagon release in 10 healthy male subjects ([means +/- SEM] aged 23 +/- 1 years, BMI 23 +/- 1 kg...
- Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis
[作者:Arden, C; Petrie, JL; Tudhope, SJ; Al-Oanzi, Z; Claydon, AJ; Beynon, RJ; Towle, HC; Agius, L,期刊:Diabetes, 页码:3110-3120 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-The induction of hepatic glucose 6-phosphatase (G6pc) by glucose presents a paradox of glucose-induced glucose intolerance. We tested whether glucose regulation of liver gene expression is geared toward intrace...
- Control of Blood Glucose in the Absence of Hepatic Glucose Production During Prolonged Fasting in Mice Induction of Renal and Intestinal Gluconeogenesis by Glucagon
[作者:Mutel, E; Gautier-Stein, A; Abdul-Wahed, A; Amigo-Correig, M; Zitoun, C; Stefanutti, A; Houberdon, I; Tourette, JA; Mithieux, G; Rajas, F,期刊:Diabetes, 页码:3121-3131 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Since the pioneering work of Claude Bernard, the scientific community has considered the liver to be the major source of endogenous glucose production in all postabsorptive situations. Nevertheless, the kidneys...
- Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice
[作者:Coomans, CP; Biermasz, NR; Geerling, JJ; Guigas, B; Rensen, PCN; Havekes, LM; Romijn, JA,期刊:Diabetes, 页码:3132-3140 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Insulin inhibits endogenous glucose production (EGP) and stimulates glucose uptake in peripheral tissues. Hypothalamic insulin signaling is required for the inhibitory effects of insulin on EGP. We examined the...
- Influence of Hyperinsulinemia and Insulin Resistance on In Vivo beta-Cell Function Their Role in Human beta-Cell Dysfunction
[作者:Mari, A; Tura, A; Natali, A; Anderwald, C; Balkau, B; Lalic, N; Walker, M; Ferrannini, E,期刊:Diabetes, 页码:3141-3147 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Recent work has shown that insulin stimulates its own secretion in insulin-sensitive humans, suggesting that insulin resistance in the beta-cell could cause beta-cell dysfunction. We have tested whether insulin...
- Duodenal PKC-delta and Cholecystokinin Signaling Axis Regulates Glucose Production
[作者:Breen, DM; Yue, JTY; Rasmussen, BA; Kokorovic, A; Cheung, GWC; Lam, TKT,期刊:Diabetes, 页码:3148-3153 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Metabolism of long-chain fatty acids within the duodenum leads to the activation of duodenal mucosal protein kinase C (PKC)-delta and the cholecystokinin (CCK)-A receptor to lower glucose production through a n...
- Modulation of beta-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia
[作者:Szepietowska, B; Zhu, WL; Chan, OW; Horblitt, A; Dziura, J; Sherwin, RS,期刊:Diabetes, 页码:3154-3158 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Norepinephrine is locally released into the ventromedial hypothalamus (VMH), a key brain glucose-sensing region in the response to hypoglycemia As a result, this neurotransmitter may play a role in modulating c...
- Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders
[作者:Kim, CS; Kim, JG; Lee, BJ; Choi, MS; Choi, HS; Kawada, T; Lee, KU; Yu, R,期刊:Diabetes, 页码:3159-3168 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Inflammation is an important factor in the development of insulin resistance, type 2 diabetes, and fatty liver disease. As a member of the tumor necrosis factor receptor superfamily (TNFRSF9) expressed on immun...
- Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia
[作者:Bolo, NR; Musen, G; Jacobson, AM; Weinger, K; McCartney, RL; Flores, V; Renshaw, PF; Simonson, DC,期刊:Diabetes, 页码:3256-3264 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-To investigate the effects of acute hypoglycemia on working memory and brain function in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS-Using blood oxygen level-dependent (BOLD) functional magnetic ...
- Decreased IRS2 and TIMP3 Expression in Monocytes From Offspring of Type 2 Diabetic Patients Is Correlated With Insulin Resistance and Increased Intima-Media Thickness
[作者:Cardellini, M; Menghini, R; Luzi, A; Davato, F; Cardolini, I; D'Alfonso, R; Gentileschi, P; Rizza, S; Marini, MA; Porzio, O; Lauro, D; Sbraccia, P; Lauro, R; Federici, M,期刊:Diabetes, 页码:3265-3270 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-In humans, it is unclear if insulin resistance at the monocyte level is associated with atherosclerosis in vivo. Here we have studied first-degree relatives of patients with type 2 diabetes to investigate wheth...
- PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic beta-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
[作者:Santin, I; Moore, F; Colli, ML; Gurzov, EN; Marselli, L; Marchetti, P; Eizirik, DL,期刊:Diabetes, 页码:3279-3288 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Genome-wide association studies allowed the identification of several associations between specific loci and type 1 diabetes (T1D). However, the mechanisms by which most candidate genes predispose to T1D remain...
- Impaired Expression of the Inducible cAMP Early Repressor Accounts for Sustained Adipose CREB Activity in Obesity
[作者:Favre, D; Le Gouill, E; Fahmi, D; Verdumo, C; Chinetti-Gbaguidi, G; Staels, B; Caiazzo, R; Pattou, F; Le, KA; Tappy, L; Regazzi, R; Giusti, V; Vollenweider, P; Waeber, G; Abderrahmani, A,期刊:Diabetes, 页码:3169-3174 , 文章类型: Article,,卷期:2011年60-12]
- OBJECTIVE-Increase in adipose cAMP-responsive element-binding protein (CREB) activity promotes adipocyte dysfunction and systemic insulin resistance in obese mice. This is achieved by increasing the expression of activat...
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