- Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy
[作者：Cassani, B; Montini, E; Maruggi, G; Ambrosi, A; Mirolo, M; Selleri, S; Biral, E; Frugnoli, I; Hernandez-Trujillo, V; Di Serio, C; Roncarolo, MG; Naldini, L; Mavilio, F; Aiuti, A,期刊：Blood, 页码：3546-3556 , 文章类型： Article，,卷期：2009年114-17]
- Gene transfer into hematopoietic stem cells by gamma-retroviral vectors (RVs) is an effective treatment for inherited blood disorders, although potentially limited by the risk of insertional mutagenesis. We evaluated the...
- Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential
[作者：Xu, HM; Eleswarapu, S; Geiger, H; Szczur, K; Daria, D; Zheng, Y; Settleman, J; Srour, EF; Williams, DA; Filippi, MD,期刊：Blood, 页码：3557-3566 , 文章类型： Article，,卷期：2009年114-17]
- Hematopoietic stem cell (HSC) engraftment is a multistep process involving HSC homing to bone marrow, self-renewal, proliferation, and differentiation to mature blood cells. Here, we show that loss of p190-B RhoGTPase ac...
- CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis
[作者：Seo, W; Ziltener, HJ,期刊：Blood, 页码：3567-3577 , 文章类型： Article，,卷期：2009年114-17]
- The sialomucin CD43 is highly expressed on most hematopoietic cells. In this study, we show that the CD43 ectodomain is shed from murine granulocytes, mast cells, and T cells, but not from macrophages. To study the signi...
- Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice
[作者：Dutta, P; Molitor-Dart, M; Bobadilla, JL; Roenneburg, DA; Yan, Z; Torrealba, JR; Burlingham, WJ,期刊：Blood, 页码：3578-3587 , 文章类型： Article，,卷期：2009年114-17]
- In mice and humans, the immunologic effects of developmental exposure to non-inherited maternal antigens (NIMAs) are quite variable. This heterogeneity likely reflects differences in the relative levels of NIMA-specific ...
- HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1
[作者：Anand, AR; Prasad, A; Bradley, RR; Deol, YS; Nagaraja, T; Ren, XH; Terwilliger, EF; Ganju, RK,期刊：Blood, 页码：3588-3600 , 文章类型： Article，,卷期：2009年114-17]
- Targeting dendritic cell (DC) functions such as migration is a pivotal mechanism used by HIV-1 to disseminate within the host. The HIV-1 envelope protein is the most important of the virally encoded proteins that exploit...
- Reduced immunoglobulin class switch recombination in the absence of Artemis
[作者：Rivera-Munoz, P; Soulas-Sprauel, P; Le Guyader, G; Abramowski, V; Bruneau, S; Fishcer, A; Paques, F; de Villartay, JP,期刊：Blood, 页码：3601-3609 , 文章类型： Article，,卷期：2009年114-17]
- Nonhomologous end-joining DNA repair factors, including Artemis, are all required for the repair of DNA double-strand breaks, which occur during the assembly of the variable antigen recognition domain of B-cell receptors...
- Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production
[作者：Volpe, E; Touzot, M; Servant, N; Marloie-Provost, MA; Hupe, P; Barillot, E; Soumelis, V,期刊：Blood, 页码：3610-3614 , 文章类型： Article，,卷期：2009年114-17]
- T helper 17 (Th17) cells produce IL-17 but can also make tumor necrosis factor, interleukin (IL)-6, IL-10, IL-21, and IL-22. These cytokines collectively contribute to the functional outcome of the Th response. IL-22 pla...
- Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells
[作者：Seiler, T; Woelfle, M; Yancopoulos, S; Catera, R; Li, WT; Hatzi, K; Moreno, C; Torres, M; Paul, S; Dohner, H; Stilgenbauer, S; Kaufman, MS; Kolitz, JE; Allen, SL; Rai, KR; Chu, CC; Chiorazzi, N,期刊：Blood, 页码：3615-3624 , 文章类型： Article，,卷期：2009年114-17]
- Despite a wealth of information about the structure of surface membrane immunoglobulin (smIg) on chronic lymphocytic leukemia (CLL) cells, little is known about epitopes reacting with their binding sites. Probing phage-d...
- Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis
[作者：Zheng, YH; Cai, Z; Wang, SQ; Zhang, X; Qian, JF; Hong, S; Li, HY; Wang, M; Yang, J; Yi, Q,期刊：Blood, 页码：3625-3628 , 文章类型： Article，,卷期：2009年114-17]
- Multiple myeloma remains an incurable disease. One of the major problems is that myeloma cells develop drug resistance on interaction with bone marrow stromal cells. In this study, we examined the effects of macrophages ...
- Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice
[作者：Cutts, BA; Sjogren, AKM; Andersson, KME; Wahlstrom, AM; Karlsson, C; Swolin, B; Bergo, MO,期刊：Blood, 页码：3629-3632 , 文章类型： Article，,卷期：2009年114-17]
- Hyperactive RAS signaling is caused by mutations in RAS genes or a deficiency of the neurofibromatosis gene (NF1) and is common in myeloid malignancies. In mice, expression of oncogenic K-RAS or inactivation of Nf1 in he...
- Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages
[作者：Jacquel, A; Benikhlef, N; Paggetti, J; Lalaoui, N; Guery, L; Dufour, EK; Ciudad, M; Racoeur, C; Micheau, O; Delva, L; Droin, N; Solary, E,期刊：Blood, 页码：3633-3641 , 文章类型： Article，,卷期：2009年114-17]
- The differentiation of human peripheral blood monocytes into resident macrophages is driven by colony-stimulating factor-1 (CSF-1), which upon interaction with CSF-1 receptor (CSF-1R) induces within minutes the phosphory...
- Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2
[作者：Nairz, M; Theurl, I; Schroll, A; Theurl, M; Fritsche, G; Lindner, E; Seifert, M; Crouch, MLV; Hantke, K; Akira, S; Fang, FC; Weiss, G,期刊：Blood, 页码：3642-3651 , 文章类型： Proceedings Paper，,卷期：2009年114-17]
- Mutations of HFE are associated with hereditary hemochromatosis, but their influence on host susceptibility to infection is incompletely understood. We report that mice lacking one or both Hfe alleles are protected from ...
- Stage-specific susceptibility of human erythroblasts to Plasmodium falciparum malaria infection
[作者：Tamez, PA; Liu, H; Fernandez-Pol, S; Haldar, K; Wickrema, A,期刊：Blood, 页码：3652-3655 , 文章类型： Article，,卷期：2009年114-17]
- Malaria parasites are known to invade and develop in erythrocytes and reticulocytes, but little is known about their infection of nucleated erythroid precursors. We used an in vitro cell system that progressed through ba...
- Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men
[作者：de Laat, B; de Groot, PG; Derksen, RHWM; Urbanus, RT; Mertens, K; Rosendaal, FR; Doggen, CJM,期刊：Blood, 页码：3656-3661 , 文章类型： Article，,卷期：2009年114-17]
- von Willebrand factor (VWF) serves as adhesive surface for platelets to adhere to the vessel wall. We have recently found that beta2-glycoprotein I is able to inhibit platelet binding to VWF, indicating a role in the pat...
- Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X
[作者：Wei, ZQ; Yan, YH; Carrell, RW; Zhou, AW,期刊：Blood, 页码：3662-3667 , 文章类型： Article，,卷期：2009年114-17]
- Protein Z (PZ) binds to PZ-dependent inhibitor (ZPI) and accelerates the inhibition of the coagulation protease, activated factor X (FXa), in the presence of phospholipids and Ca2+. A 2.3 angstrom resolution crystal stru...
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