- Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the anti-inflammatory capacity in RAW264.7 macrophages
[作者:Jeon, WK; Hong, HY; Kim, BC,期刊:Archives of Biochemistry and Biophysics , 页码:119-125 , 文章类型: Article,,卷期:2011年512-2]
- Genipin, an aglycon of geniposide, has been reported to exhibit diverse pharmacological functions such as antitumor and anti-inflammatory effects. This study aimed to elucidate the anti-inflammatory mechanism of genipin,...
- Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23)
[作者:Nunes, JES; Ducati, RG; Breda, A; Rosado, LA; de Souza, BM; Palma, MS; Santos, DS; Basso, LA,期刊:Archives of Biochemistry and Biophysics , 页码:143-153 , 文章类型: Article,,卷期:2011年512-2]
- The emergence of drug-resistant strains of Mycobacterium tuberculosis, the major causative agent of tuberculosis (TB), and the deadly HIV-TB co-infection have led to an urgent need for the development of new anti-TB drug...
- A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis
[作者:Evans, G; Schuldt, L; Griffin, MDW; Devenish, SRA; Pearce, FG; Perugini, MA; Dobson, RCJ; Jameson, GB; Weiss, MS; Gerrard, JA,期刊:Archives of Biochemistry and Biophysics , 页码:154-159 , 文章类型: Article,,卷期:2011年512-2]
- Dihydrodipicolinate synthase (DHDPS) is a validated antibiotic target for which a new approach to inhibitor design has been proposed: disrupting native tetramer formation by targeting the dimer-dimer interface. In this s...
- Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus
[作者:Dommaraju, SR; Dogovski, C; Czabotar, PE; Hor, L; Smith, BJ; Perugini, MA,期刊:Archives of Biochemistry and Biophysics , 页码:167-174 , 文章类型: Article,,卷期:2011年512-2]
- Given the rapid rise in antibiotic resistance, including methicillin resistance in Staphylococcus aureus (MRSA), there is an urgent need to characterize novel drug targets. Enzymes of the lysine biosynthesis pathway in b...
- Redox reactions of the FAD-containing apoptosis-inducing factor (AIF) with quinoidal xenobiotics: A mechanistic study
[作者:Miseviciene, L; Anusevicius, Z; Sarlauskas, J; Sevrioukova, IF; Cenas, N,期刊:Archives of Biochemistry and Biophysics , 页码:183-189 , 文章类型: Article,,卷期:2011年512-2]
- Mitochondrial apoptosis-inducing factor (AIF) is a FAD-containing protein that under certain conditions translocates to the nucleus and causes a programmed cell death, apoptosis. The apoptogenic action of AIF is redox co...
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