- Antiangiogenic Gene Therapy of Solid Tumor by Systemic Injection of Polyplex Micelles Loading Plasmid DNA Encoding Soluble Flt-1
[作者:Oba, M; Vachutinsky, Y; Miyata, K; Kano, MR; Ikeda, S; Nishiyama, N; Itaka, K; Miyazono, K; Koyama, H; Kataoka, K,期刊:Molecular Pharmaceutics, 页码:501-509 , 文章类型: Article,,卷期:2010年7-2]
- In this study, a polyplex micelle was developed as a potential formulation for antiangiogenic gene therapy of subcutaneous pancreatic tumor model. Poly(ethylene glycol)-poly(L-lysine) block copolymers (PEG-PLys) with thi...
- Silica Nanoparticles To Control the Lipase-Mediated Digestion of Lipid-Based Oral Delivery Systems
[作者:Tan, A; Simovic, S; Davey, AK; Rades, T; Boyd, BJ; Prestidge, CA,期刊:Molecular Pharmaceutics, 页码:522-532 , 文章类型: Article,,卷期:2010年7-2]
- We investigate the role of hydrophilic fumed silica in controlling the digestion kinetics of lipid emulsions, hence further exploring the mechanisms behind the improved oral absorption of poorly soluble drugs promoted by...
- Novel Method for Concentrating and Drying Polymeric Nanoparticles: Hydrogen Bonding Coacervate Precipitation
[作者:D'Addio, SM; Kafka, C; Akbulut, M; Beattie, P; Saad, W; Herrera, M; Kennedy, MT; Prud'homme, RK,期刊:Molecular Pharmaceutics, 页码:557-564 , 文章类型: Article,,卷期:2010年7-2]
- Nanoparticles have significant potential in therapeutic applications to improve the bioavailability and efficacy of active drug compounds. However, the retention of nanometer sizes during concentrating or drying steps pr...
- Mechanisms of Phospholipid Complex Loaded Nanoparticles Enhancing the Oral Bioavailability
[作者:Peng, Q; Zhang, ZR; Sun, X; Zuo, J; Zhao, D; Gong, T,期刊:Molecular Pharmaceutics, 页码:565-575 , 文章类型: Article,,卷期:2010年7-2]
- The purpose of the present study was to study the mechanisms of salvianolic acid B phospholipid complex loaded nanoparticles (SalB-PLC-NPs) enhancing the oral bioavailability of SalB by in situ perfusion model in rats an...
- Selective Apoptotic Killing of Solid and Hematologic Tumor Cells by Bombesin-Targeted Delivery of Mitochondria-Disrupting Peptides
[作者:Cai, HW; Yang, H; Xiang, B; Li, SF; Liu, S; Wan, L; Zhang, J; Li, YP; Cheng, JQ; Lu, XF,期刊:Molecular Pharmaceutics, 页码:586-596 , 文章类型: Article,,卷期:2010年7-2]
- Tumor-homing peptides are attractive tools for tumor imaging and targeted therapy due to their ability to specifically bind and enter tumor cells and masses. Bombesin and its analogues show promise for the targeted deliv...
- Development of a Poly(D,L-lactic-co-glycolic acid) Nanoparticle Formulation of STAT3 Inhibitor JSI-124: Implication for Cancer Immunotherapy
[作者:Molavi, L; Mahmud, A; Hamdy, S; Hung, RW; Lai, R; Samuel, J; Lavasanifar, A,期刊:Molecular Pharmaceutics, 页码:364-374 , 文章类型: Article,,卷期:2010年7-2]
- Constitutively activated signal transducer and activator of transcription-3 (STAT3) in tumor and dendritic cells (DCs) plays a critical role in tumor-induced immunosuppression. This is considered a major challenge in eff...
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