- Monotherapy clinical trial design
[作者：Sachdeo, R,期刊：Neurology, 页码：S23-S27 , 文章类型： Article，,卷期：2007年69-24]
- Monotherapy of epilepsy is usually preferable to polytherapy for a variety of reasons. However, investigational or newer antiepileptic drugs (AEDs) are typically evaluated as add-on therapy in patients with refractory se...
- Cardiovascular autonomic function in poststroke patients
[作者：Dutsch, M; Burger, M; Dorfler, C; Schwab, S; Hilz, MJ,期刊：Neurology, 页码：2249-2255 , 文章类型： Article，,卷期：2007年69-24]
- Background: Autonomic dysregulation is frequent in acute ischemic stroke. Several studies concluded that imbalance between sympathetic and parasympathetic cardiovascular function predisposes to malignant cardiac arrhythm...
- Clinical Reasoning: A 59-year-old woman with acute paraplegia
[作者：Prasad, S; Price, RS; Kranick, SM; Woo, JH; Hurst, RW; Galetta, S,期刊：Neurology, 页码：E41-E47 , 文章类型： Article，,卷期：2007年69-24]
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- Monotherapy in adults and elderly persons
[作者：Faught, E,期刊：Neurology, 页码：S3-S9 , 文章类型： Article，,卷期：2007年69-24]
- Treatment of epilepsy with a single drug has many advantages. Potential benefits of monotherapy vs polytherapy include fewer adverse events and better tolerability, avoidance of drug -drug interactions, reduced treatment...
- Animal model studies application to human patients
[作者：Holmes, GL,期刊：Neurology, 页码：S28-S32 , 文章类型： Article，,卷期：2007年69-24]
- Animal models are used to identify potential new antiepileptic drugs (AEDs) and to study the effects of combining AEDs with different mechanisms of action. The models most commonly used to identify new AEDs are the maxim...
- Longitudinally preserved psychomotor performance in long-term asymptomatic HIV-infected individuals
[作者：Cole, MA; Margolick, JB; Cox, C; Li, X; Selnes, OA; Martin, EM; Becker, JT; Aronow, HA; Cohen, B; Sacktor, N; Miller, EN,期刊：Neurology, 页码：2213-2220 , 文章类型： Article，,卷期：2007年69-24]
- Background: Recent case reports have suggested that some asymptomatic HIV-infected individuals can develop CNS disturbances despite intact immunologic functioning and long-term suppression of plasma HIV concentrations to...
- Clinical, electrophysiologic, and pathologic evidence for sensory abnormalities in ALS
[作者：Hammad, M; Silva, A; Glass, J; Sladky, JT; Benatar, M,期刊：Neurology, 页码：2236-2242 , 文章类型： Article，,卷期：2007年69-24]
- Background: Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease of upper and lower motor neurons. Reports of the nature and frequency of sensory nerve involvement in ALS have varied.Methods: We revi...
- A subcortical network of dysfunction in TLE measured by magnetic resonance spectroscopy
[作者：Hetherington, HP; Kuzniecky, RI; Vives, K; Devinsky, O; Pacia, S; Luciano, D; Vasquez, B; Haut, S; Spencer, DD; Pan, JW,期刊：Neurology, 页码：2256-2265 , 文章类型： Article，,卷期：2007年69-24]
- Objective: The goal of this work was to evaluate the relationship between neuronal injury/loss in the hippocampus, thalamus, and putamen in temporal lobe epilepsy (TLE) patients using H-1 magnetic resonance spectroscopic...
- Monotherapy in children and infants
[作者：Wilfong, AA,期刊：Neurology, 页码：S17-S22 , 文章类型： Article，,卷期：2007年69-24]
- An expanding array of antiepileptic drugs (AEDs) is available to treat childhood epilepsy, offering the potential for improved seizure control and quality of life in this important patient population but also providing c...
- Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI
[作者：Ewers, M; Buerger, K; Teipel, SJ; Scheltens, P; Schroder, J; Zinkowski, RP; Bouwman, FH; Schonknecht, P; Schoonenboom, NSM; Andreasen, N; Wallin, A; DeBernardis, JF; Kerkman, DJ; Heindl, B; Blennow, K; Hampel, H,期刊：Neurology, 页码：2205-2212 , 文章类型： Article，,卷期：2007年69-24]
- Background: The measurement of hyperphosphorylated tau (p-tau) in CSF has been proposed as a biomarker candidate for the prediction of Alzheimer disease ( AD) in patients with mild cognitive impairment (MCI). However, a ...
- Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica
[作者：Hinson, SR; Pittock, SJ; Lucchinetti, CF; Roemer, SF; Fryer, JP; Kryzer, TJ; Lennon, VA,期刊：Neurology, 页码：2221-2231 , 文章类型： Article，,卷期：2007年69-24]
- Background: Autoantibody specific for the aquaporin-4 astrocytic water channel is restricted to serum and CSF of patients with neuromyelitis optica (NMO) and related CNS inflammatory demyelinating disorders ( relapsing o...
- Rating the approachability of faces in ALS
[作者：Schmolck, H; Mosnik, D; Schulz, P,期刊：Neurology, 页码：2232-2235 , 文章类型： Article，,卷期：2007年69-24]
- Background: Several groups have found that a significant percentage of patients with amyotrophic lateral sclerosis (ALS) have cognitive impairment. Here we investigate whether the amygdala, a temporal lobe structure, is ...
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