- Wnt Signaling and Aging-Related Heart Disorders
[作者：Naito, AT; Shiojima, I; Komuro, I,期刊：Circulation Research, 页码：1295-1303 , 文章类型： Review，,卷期：2010年107-11]
- Aging is associated with various heart diseases, and this may be attributable, in part, to the prolonged exposure of the heart to cardiovascular risk factors. However, aging is also associated with heart disorders such a...
- Origins of Cardiac Fibroblasts
[作者：Zeisberg, EM; Kalluri, R,期刊：Circulation Research, 页码：1304-1312 , 文章类型： Review，,卷期：2010年107-11]
- Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac rem...
- Thrombospondin-4 Regulates Vascular Inflammation and Atherogenesis
[作者：Frolova, EG; Pluskota, E; Krukovets, I; Burke, T; Drumm, C; Smith, JD; Blech, L; Febbraio, M; Bornstein, P; Plow, EF; Stenina, OI,期刊：Circulation Research, 页码：1313-U55 , 文章类型： Article，,卷期：2010年107-11]
- Rationale: Thrombospondin (TSP)-4 is an extracellular protein that has been linked to several cardiovascular pathologies. However, a role for TSP-4 in vascular wall biology remains unknown. Objective: We have examined th...
- The Neuropeptide Catestatin Acts As a Novel Angiogenic Cytokine via a Basic Fibroblast Growth Factor-Dependent Mechanism
[作者：Theurl, M; Schgoer, W; Albrecht, K; Jeschke, J; Egger, M; Beer, AGE; Vasiljevic, D; Rong, S; Wolf, AM; Bahlmann, FH; Patsch, JR; Wolf, D; Schratzberger, P; Mahata, SK; Kirchmair, R,期刊：Circulation Research, 页码：1326-U95 , 文章类型： Article，,卷期：2010年107-11]
- Rationale: The neuropeptide catestatin is an endogenous nicotinic cholinergic antagonist that acts as a pleiotropic hormone. Objective: Catestatin shares several functions with angiogenic factors. We therefore reasoned t...
- RGS6, a Modulator of Parasympathetic Activation in Heart
[作者：Yang, JQ; Huang, J; Maity, B; Gao, Z; Lorca, RA; Gudmundsson, H; Li, JD; Stewart, A; Swaminathan, PD; Ibeawuchi, SR; Shepherd, A; Chen, CK; Kutschke, W; Mohler, PJ; Mohapatra, DP; Anderson, ME; Fisher, RA,期刊：Circulation Research, 页码：1345-U128 , 文章类型： Article，,卷期：2010年107-11]
- Rationale: Parasympathetic regulation of heart rate is mediated by acetylcholine binding to G protein-coupled muscarinic M2 receptors, which activate heterotrimeric G(i/o) proteins to promote G protein-coupled inwardly r...
- RGS6/G beta 5 Complex Accelerates I-KACh Gating Kinetics in Atrial Myocytes and Modulates Parasympathetic Regulation of Heart Rate
[作者：Posokhova, E; Wydeven, N; Allen, KL; Wickman, K; Martemyanov, KA,期刊：Circulation Research, 页码：1350-U143 , 文章类型： Article，,卷期：2010年107-11]
- Rationale: The parasympathetic reduction in heart rate involves the sequential activation of m2 muscarinic cholinergic receptors (m(2)Rs), pertussis toxin-sensitive (Gi/o) heterotrimeric G proteins, and the atrial potass...
- Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction
[作者：Leuschner, F; Panizzi, P; Chico-Calero, I; Lee, WW; Ueno, T; Cortez-Retamozo, V; Waterman, P; Gorbatov, R; Marinelli, B; Iwamoto, Y; Chudnovskiy, A; Figueiredo, JL; Sosnovik, DE; Pittet, MJ; Swirski, FK; Weissleder, R; Nahrendorf, M,期刊：Circulation Research, 页码：1364-U181 , 文章类型： Article，,卷期：2010年107-11]
- Rationale: Monocytes recruited to ischemic myocardium originate from a reservoir in the spleen, and the release from their splenic niche relies on angiotensin (Ang) II signaling. Objective: Because monocytes are centrall...
- Myocyte Turnover in the Aging Human Heart
[作者：Kajstura, J; Gurusamy, N; Ogorek, B; Goichberg, P; Clavo-Rondon, C; Hosoda, T; D'Amario, D; Bardelli, S; Beltrami, AP; Cesselli, D; Bussani, R; del Monte, F; Quaini, F; Rota, M; Beltrami, CA; Buchholz, BA; Leri, A; Anversa, P,期刊：Circulation Research, 页码：1374-U194 , 文章类型： Article，,卷期：2010年107-11]
- Rationale: The turnover of cardiomyocytes in the aging female and male heart is currently unknown, emphasizing the need to define human myocardial biology. Objective: The effects of age and gender on the magnitude of myo...
- The Critical Role of Neutral Cholesterol Ester Hydrolase 1 in Cholesterol Removal From Human Macrophages
[作者：Igarashi, M; Osuga, J; Uozaki, H; Sekiya, M; Nagashima, S; Takahashi, M; Takase, S; Takanashi, M; Li, YX; Ohta, K; Kumagai, M; Nishi, M; Hosokawa, M; Fledelius, C; Jacobsen, P; Yagyu, H; Fukayama, M; Nagai, R; Kadowaki, T; Ohashi, K; Ishibashi, S,期刊：Circulation Research, 页码：1387-U226 , 文章类型： Article，,卷期：2010年107-11]
- Rationale: Hydrolysis of intracellular cholesterol ester (CE) is the key step in the reverse cholesterol transport in macrophage foam cells. We have recently shown that neutral cholesterol ester hydrolase (Nceh)1 and hor...
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