- P-Selectin Glycoprotein Ligand-1 Regulates Adhesive Properties of the Endothelium and Leukocyte Trafficking Into Adipose Tissue
[作者：Russo, HM; Wickenheiser, KJ; Luo, W; Ohman, MK; Franchi, L; Wright, AP; Bodary, PF; Gabriel, N; Eitzman, DT,期刊：Circulation Research, 页码：388-388 , 文章类型： Article，,卷期：2010年107-3]
- Rationale: Adhesive interactions between endothelial cells and leukocytes affect leukocyte trafficking in adipose tissue. The role of P-selectin glycoprotein ligand-1 (Psgl-1) in this process is unclear. Objective: The g...
- Alterations of L-Type Calcium Current and Cardiac Function in CaMKII delta Knockout Mice
[作者：Xu, L; Lai, DW; Cheng, J; Lim, HJ; Keskanokwong, T; Backs, J; Olson, EN; Wang, YG,期刊：Circulation Research, 页码：398-407 , 文章类型： Article，,卷期：2010年107-3]
- Rationale: Recent studies have highlighted important roles of CaMKII in regulating Ca2+ handling and excitation-contraction coupling. However, the cardiac effect of chronic CaMKII inhibition has not been well understood....
- VEGF Blockade Inhibits Lymphocyte Recruitment and Ameliorates Immune-Mediated Vascular Remodeling
[作者：Zhang, JS; Silva, T; Yarovinsky, T; Manes, TD; Tavakoli, S; Nie, L; Tellides, G; Pober, JS; Bender, JR; Sadeghi, MM,期刊：Circulation Research, 页码：408-408 , 文章类型： Article，,卷期：2010年107-3]
- Rationale: There are conflicting data on the effects of vascular endothelial growth factor (VEGF) in vascular remodeling. Furthermore, there are species-specific differences in leukocyte and vascular cell biology and lit...
- Smad3 Signaling Critically Regulates Fibroblast Phenotype and Function in Healing Myocardial Infarction
[作者：Dobaczewski, M; Bujak, M; Li, N; Gonzalez-Quesada, C; Mendoza, LH; Wang, XF; Frangogiannis, NG,期刊：Circulation Research, 页码：418-418 , 文章类型： Article，,卷期：2010年107-3]
- Rationale: Cardiac fibroblasts are key effector cells in the pathogenesis of cardiac fibrosis. Transforming growth factor (TGF)-beta/Smad3 signaling is activated in the border zone of healing infarcts and induces fibroti...
- Inhibition of Notch1-Dependent Cardiomyogenesis Leads to a Dilated Myopathy in the Neonatal Heart
[作者：Urbanek, K; Cabral-da-Silva, MC; Ide-Iwata, N; Maestroni, S; Delucchi, F; Zheng, HQ; Ferreira-Martins, J; Ogorek, B; D'Amario, D; Bauer, M; Zerbini, G; Rota, M; Hosoda, T; Liao, RL; Anversa, P; Kajstura, J; Leri, A,期刊：Circulation Research, 页码：429-429 , 文章类型： Article，,卷期：2010年107-3]
- Rationale: Physiological hypertrophy in the developing heart has been considered the product of an increase in volume of preexisting fetal cardiomyocytes in the absence of myocyte formation. Objective: In this study, we ...
- Epigenome Mapping in Normal and Disease States
[作者：Maunakea, AK; Chepelev, I; Zhao, KJ,期刊：Circulation Research, 页码：327-339 , 文章类型： Article，,卷期：2010年107-3]
- Epigenomes are comprised, in part, of all genome-wide chromatin modifications, including DNA methylation and histone modifications. Unlike the genome, epigenomes are dynamic during development and differentiation to esta...
- Reporter-Based Isolation of Induced Pluripotent Stem Cell- and Embryonic Stem Cell-Derived Cardiac Progenitors Reveals Limited Gene Expression Variance
[作者：van Laake, LW; Qian, L; Cheng, P; Huang, Y; Hsiao, EC; Conklin, BR; Srivastava, D,期刊：Circulation Research, 页码：340-347 , 文章类型： Article，,卷期：2010年107-3]
- Rationale: Induced pluripotent stem (iPS) cells can differentiate into multiple cell types, including cardiomyocytes and have tremendous potential for drug discovery and regenerative therapies. However, it is unknown how...
- Loss of Enigma Homolog Protein Results in Dilated Cardiomyopathy
[作者：Cheng, HQ; Kimura, K; Peter, AK; Cui, L; Ouyang, KF; Shen, T; Liu, YJ; Gu, YS; Dalton, ND; Evans, SM; Knowlton, KU; Peterson, KL; Chen, J,期刊：Circulation Research, 页码：348-348 , 文章类型： Article，,卷期：2010年107-3]
- Rationale: The Z-line, alternatively termed the Z-band or Z-disc, is a highly ordered structure at the border between 2 sarcomeres. Enigma subfamily proteins (Enigma, Enigma homolog protein, and Cypher) of the PDZ-LIM do...
- Impact of Combined Deficiency of Hepatic Lipase and Endothelial Lipase on the Metabolism of Both High-Density Lipoproteins and Apolipoprotein B-Containing Lipoproteins
[作者：Brown, RJ; Lagor, WR; Sankaranaravanan, S; Yasuda, T; Quertermous, T; Rothblat, GH; Rader, DJ,期刊：Circulation Research, 页码：357-357 , 文章类型： Article，,卷期：2010年107-3]
- Rationale: Hepatic lipase (HL) and endothelial lipase (EL) are extracellular lipases that both hydrolyze triglycerides and phospholipids and display potentially overlapping or complementary roles in lipoprotein metabolis...
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