- Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice
[作者：Liu, YW; Teige, A; Mondoc, E; Ibrahim, S; Holmdahl, R; Issazadeh-Navikas, S,期刊：Journal of clinical investigation, 页码：249-264 , 文章类型： Article，,卷期：2011年121-1]
- NKT cells m the mouse recognize antigen in the context of the MHC class I-like molecule CD1d and play an important role in peripheral tolerance and protection against autoimmune and other diseases NKT cells are usually a...
- Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis
[作者：Kreisel, D; Sugimoto, S; Tietjens, J; Zhu, JH; Yamamoto, S; Krupnick, AS; Carmody, RJ; Gelman, AE,期刊：Journal of clinical investigation, 页码：265-276 , 文章类型： Article，,卷期：2011年121-1]
- Granulocytes are pivotal regulators of tissue injury However, the transcriptional mechanisms that regulate granulopoiesis under inflammatory conditions are poorly understood Here we show that the transcriptional coregula...
- Epithelium-specific deletion of TGF-beta receptor type II protects mice from bleomycin-induced pulmonary fibrosis
[作者：Li, M; Krishnaveni, MS; Li, CG; Zhou, BY; Xing, YM; Banfalvi, A; Li, AM; Lombardi, V; Akbari, O; Borok, Z; Minoo, P,期刊：Journal of clinical investigation, 页码：277-287 , 文章类型： Article，,卷期：2011年121-1]
- Idiopathic pulmonary fibrosis (IPF) is a chronic fibroproliferative pulmonary disorder for which there are currently no treatments Although the etiology of IPF is unknown, dysregulated TGF-beta signaling has been implica...
- Paired analysis of TCR alpha and TCR beta chains at the single-cell level in mice
[作者：Dash, P; McClaren, JL; Oguin, TH; Rothwell, W; Todd, B; Morris, MY; Becksfort, J; Reynolds, C; Brown, SA; Doherty, PC; Thomas, PG,期刊：Journal of clinical investigation, 页码：288-295 , 文章类型： Article，,卷期：2011年121-1]
- Characterizing the TCR alpha and TCR beta chains expressed by T cells responding to a given pathogen or underlying autoimmunity helps in the development of vaccines and immunotherapies, respectively However, our understa...
- The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice
[作者：Salek-Ardakani, S; Flynn, R; Arens, R; Yagita, H; Smith, GL; Borst, J; Schoenberger, SP; Croft, M,期刊：Journal of clinical investigation, 页码：296-307 , 文章类型： Article，,卷期：2011年121-1]
- Induction of CD8(+) T cell immunity is a key characteristic of an effective vaccine For safety reasons, human vaccination strategies largely use attenuated nonreplicating or weakly replicating pox-virus-based vectors, bu...
- Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV
[作者：Casrouge, A; Decalf, J; Ahloulay, M; Lababidi, C; Mansour, H; Vallet-Pichard, A; Mallet, V; Mottez, E; Mapes, J; Fontanet, A; Pol, S; Albert, ML,期刊：Journal of clinical investigation, 页码：308-317 , 文章类型： Article，,卷期：2011年121-1]
- Chronic infection with hepatitis C virus (HCV) is a major public health problem, with nearly 170 million infected individuals worldwide Current treatment for chronic infection is a combination of pegylated. IFN-alpha(2) ...
- Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice
[作者：Mori, M; Kitazume, M; Ose, R; Kurokawa, J; Koga, K; Osuga, Y; Arai, S; Miyazaki, T,期刊：Journal of clinical investigation, 页码：318-327 , 文章类型： Article，,卷期：2011年121-1]
- During intrauterine life, the mammalian embryo survives via its physical connection to the mother The uterine decidua, which differentiates from stromal cells after implantation in a process known as decidualization, pla...
- Identification of SOX3 as an XX male sex reversal gene in mice and humans
[作者：Sutton, E; Hughes, J; White, S; Sekido, R; Tan, J; Arboleda, V; Rogers, N; Knower, K; Rowley, L; Eyre, H; Rizzoti, K; McAninch, D; Goncalves, J; Slee, J; Turbitt, E; Bruno, D; Bengtsson, H; Harley, V; Vilain, E; Sinclair, A; Lovell-Badge, R; Thomas, P,期刊：Journal of clinical investigation, 页码：328-341 , 文章类型： Article，,卷期：2011年121-1]
- Sex in mammals is genetically determined and is defined at the cellular level by sex chromosome complement (XY males and X,C females) The Y chromosome-linked gene sex-determining region Y (SRY) is believed to be the mast...
- Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver
[作者：Onoyama, I; Suzuki, A; Matsumoto, A; Tomita, K; Katagiri, H; Oike, Y; Nakayama, K; Nakayama, KI,期刊：Journal of clinical investigation, 页码：342-354 , 文章类型： Article，,卷期：2011年121-1]
- E3 ubiquitin ligase complexes of the SCF type consist of ring-box 1 (Rbx1), cullin 1 (Cull), S-phase kinase-associated protein 1 (Skp1), and a member of the F-box family of proteins The identity of the F-box protein dete...
- Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
[作者：Donato, J; Cravo, RM; Frazao, R; Gautron, L; Scott, MM; Lachey, J; Castro, IA; Margatho, LO; Lee, S; Lee, C; Richardson, JA; Friedman, J; Chua, S; Coppari, R; Zigman, JM; Elmquist, JK; Elias, CF,期刊：Journal of clinical investigation, 页码：355-368 , 文章类型： Article，,卷期：2011年121-1]
- Studies m hum ins and rodents indicate that a minimum amount of stored energy is required for normal pubertal development The adipocyte-derived hormone leptin is a key metabolic signal to the neuroendocrine reproductive ...
- mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice
[作者：Zhao, C; Yasumura, D; Li, XY; Matthes, M; Lloyd, M; Nielsen, G; Ahern, K; Snyder, M; Bok, D; Dunaief, JL; LaVail, MM; Vollrath, D,期刊：Journal of clinical investigation, 页码：369-383 , 文章类型： Article，,卷期：2011年121-1]
- Retinal pigment epithelial (RPE) cell dysfunction plays a central role in various retinal degenerative diseases, but knowledge 1, limited regarding the pathways responsible for adult RPE stress responses in vivo RPE mito...
- Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R gamma c-deficient mice
[作者：Sarry, JE; Murphy, K; Perry, R; Sanchez, PV; Secreto, A; Keefer, C; Swider, CR; Strzelecki, AC; Cavelier, C; Recher, C; Mansat-De Mas, V; Delabesse, E; Danet-Desnoyers, G; Carroll, M,期刊：Journal of clinical investigation, 页码：384-395 , 文章类型： Article，,卷期：2011年121-1]
- Human leukemic stem cells, like other cancer stem cells, are hypothesized to be rare, capable of incomplete differentiation, and restricted to a phenotype associated with early hematopoietic progenitors or stem cells How...
- Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
[作者：Corbin, AS; Agarwal, A; Loriaux, M; Cortes, J; Deininger, MW; Druker, BJ,期刊：Journal of clinical investigation, 页码：396-409 , 文章类型： Article，,卷期：2011年121-1]
- Imatinib therapy, which targets the oncogene product BCR-ABL, has transformed chronic myeloid leukemia (CML) from a life-threatening disease into a chronic condition Most patients, however, harbor residual leukemia cells...
- Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions
[作者：Zibert, JR; Wallbrecht, K; Schon, M; Mir, LM; Jacobsen, GK; Trochon-Joseph, V; Bouquet, C; Villadsen, LS; Cadossi, R; Skov, L; Schon, MP,期刊：Journal of clinical investigation, 页码：410-421 , 文章类型： Article，,卷期：2011年121-1]
- Dysregulated angiogenesis is a hallmark of chronic inflammatory diseases, including psoriasis, a common skin disorder that affects approximately 2% of the population Studying both human psoriasis in 2 complementary xenot...
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