个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共29条记录   Copper-Catalyzed Electrophilic Amination of Organoboron Compounds [作者：LALIC GOJKO; RUCKER RICHARD P,期刊：SYNLETT, 页码：269-275 , 文章类型： Article，,卷期：2013年-3] A new procedure for direct transformation of alkenes to tertiary alkylamines based on hydroboration and copper-catalyzed amination of alkylboranes is described. The new method is presented in a broader context provided b... An Update on Catalytic Strategies for the Synthesis of alpha-Hydroxyketones [作者：STREUFF JAN,期刊：SYNLETT, 页码：276-280 , 文章类型： Article，,卷期：2013年-3] The catalytic asymmetric synthesis of alpha-oxygenated ketones is still a challenge to modern methodology. This SYNPACTS gives an overview on recent developments in this area and besides direct alpha-oxidation protocols,... Stereoselective Organocatalytic Alkylations with Carbenium Ions [作者：GUALANDI ANDREA; COZZI PIER GIORGIO,期刊：SYNLETT, 页码：281-296 , 文章类型： Article，,卷期：2013年-3] Diastereoselective S(N)1-type reactions have been known for many years and have been used in the synthesis of many natural products. It has recently been shown that chiral nucleophiles, obtained using organocatalytic met... Cluster Preface: Process Chemistry [作者：YASUDA NOBUYOSHI,期刊：SYNLETT, 页码：298-300 , 文章类型： Article，,卷期：2013年-3] The goal of process chemistry is to identify cost-effective, robust and environmentally friendly manufacturing routes for drug candidates. This article outlines the importance of scientific innovation to overcome the man... Development of a Scalable Synthesis of a VEGFR Inhibitor [作者：CHEN YING; CROCKETT RICHARD D; WANG XIN; LARSEN ROBERT D; CUI SHENG; FAUL MARGARET M,期刊：SYNLETT, 页码：301-304 , 文章类型： Article，,卷期：2013年-3] Process development and salt selection for a novel VEGFR inhibitor are described. The overall convergent synthesis involved coupling of three key fragments, 2-chloronicotinoyl chloride, 4-isopropyl-3-methylaniline and 7-... Evolution of the Process for the Preparation of a Selective ErbB VEGF Receptor Inhibitor [作者：MUDRYK BOGUSLAW; JOSHI AMIT; ORTIZ ADRIAN; YOUNG IAN S; SAWYER JAMES R; ZHENG BIN; SUGIYAMA MASANO; SHI ZHONGPING; MUESLEHIDDINOGLU JALE; CORBETT R MICHAEL; KRONENTHAL DAVID R; CONLON DAVID A,期刊：SYNLETT, 页码：305-312 , 文章类型： Article，,卷期：2013年-3] An efficient synthetic route to the potent and selective ErbB VEGF receptor inhibitor, BMS-690514 (1) is described. Strategic modifications in both approach and procedure addressed several issues, which led to a safe, ef... New Synthesis of 2 ',4 '-Functionalized Nucleotides via Stereospecific Hydrogenation and Azidation Reactions [作者：HOUPIS IOANNIS N; LEMAIRE SEBASTIEN; FARINA VITTORIO; XIAO TINGTING; LIU RENMAO; NETTEKOVEN ULRIKE; WANG YOUCHU,期刊：SYNLETT, 页码：313-316 , 文章类型： Article，,卷期：2013年-3] The synthesis of an anti-infective nucleoside derivative was accomplished through selective hydrogenation using an achiral ligand to establish the stereochemistry of the 2' stereogenic center. The quaternary 4' center wa... Development of a Practical Synthesis of 4-[6-(Morpholinomethyl)-pyridin-3-yl]naphthalen-1-amine, a Key Intermediate for the Synthesis of BIRB 1017, a Potent p38 MAP Kinase Inhibitor [作者：LU BRUCE Z; LI GUISHENG; RODRIGUEZ SONIA; LIU JIANXU; ERIKSSON MAGNUS C; TAN ZHULIN; SONG JINHUA J; YEE NATHAN K; FARINA VITTORIO; SENANAYAKE CHRIS H,期刊：SYNLETT, 页码：317-322 , 文章类型： Article，,卷期：2013年-3] The development of synthetic routes to 4-[6-(morpholinomethyl)pyridin-3-yl]naphthalen-1-amine, the key intermediate of p38 MAP kinase inhibitor BIRB 1017, via (1) trialkylmagnesium ate complex mediated metalation and bor... Process Development of Halaven (R): Synthesis of the C1-C13 Fragment from D-(-)-Gulono-1,4-lactone [作者：CHASE CHARLES E; FANG FRANCIS G; LEWIS BRYAN M; WILKIE GORDON D; SCHNADERBECK MATTHEW J; ZHU XIAOJIE,期刊：SYNLETT, 页码：323-326 , 文章类型： Article，,卷期：2013年-3] A 12-step kilogram-scale synthesis of the C1-C13 fragment, common to halichondrin B and the totally synthetic analogue Halaven (R) (E7389, INN eribulin mesylate), is described. The synthesis features four crystalline int... Process Development of Halaven (R): Synthesis of the C14-C35 Fragment via Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization [作者：AUSTAD BRIAN C; BENAYOUD FARID; CALKINS TREVOR L; CAMPAGNA SILVIO; CHASE CHARLES E; CHOI HYEONGWOOK; CHRIST WILLIAM; COSTANZO ROBERT; CUTTER JAMES; ENDO ATSUSHI; FANG FRANCIS G; HU YONGBO; LEWIS BRYAN M; LEWIS MICHAEL D; MCKENNA SHAWN; NOLAND THOMAS A; ORR JOHN D; PESANT MARC; SCHNADERBECK MATTHEW J; WILKIE GORDON D; ABE TAICHI; ASAI NAOKI; ASAI YUMI; KAYANO AKIO; KIMOTO YUICHI; KOMATSU YUKI; KUBOTA MANABU; KURODA HIROFUMI; MIZUNO MASANORI; NAKAMURA TAIJU; OMAE TAKAO; OZEKI NAOKI; SUZUKI TAEKO; TAKIGAWA TEIJI; WATANABE TOMOHIRO; YOSHIZAWAB KAZUHIRO,期刊：SYNLETT, 页码：327-332 , 文章类型： Article，,卷期：2013年-3] Multikilogram manufacturing process of the Halaven (R) C14-C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment. Commercial Manufacture of Halaven (R): Chemoselective Transformations En Route to Structurally Complex Macrocyclic Ketones [作者：AUSTAD BRIAN C; CALKINS TREVOR L; CHASE CHARLES E; FANG FRANCIS G; HORSTMANN THOMAS E; HU YONGBO; LEWIS BRYAN M; NIU XIANG; NOLAND THOMAS A; ORR JOHN D; SCHNADERBECK MATTHEW J; ZHANG HUIMING; ASAKAWA NAOKI; ASAI NAOKI; CHIBA HIROYUKI; HASEBE TAKASHI; HOSHINO YORIHISA; ISHIZUKA HIROYUKI; KAJIMA TAKASHI; KAYANO AKIO; KOMATSU YUKI; KUBOTA MANABU; KURODA HIROFUMI; MIYAZAWA MAMORU; TAGAMI KATSUYA; WATANABEB TOMOHIRO,期刊：SYNLETT, 页码：333-337 , 文章类型： Article，,卷期：2013年-3] The evolution of the synthesis of Halaven (R) (E7389, INN eribulin mesylate) from a medicinal chemistry process to the execution of the final process on pilot scale is described. The completion of the synthesis of Halave... High Surface Area CeO2 Promoted Suzuki-Miyaura Cross-Coupling of Arylboronic Acids and Aryl Iodides [作者：GRAZIANO MAYER MARILYN; NADOR FABIANA; ALICIA VOLPE MARIA; RADIVOY GABRIEL,期刊：SYNLETT, 页码：338-342 , 文章类型： Article，,卷期：2013年-3] High surface area cerium oxide (240 m(2)/g) efficiently promoted the Suzuki-Miyaura cross-coupling of aryl iodides with arylboronic acids, in the absence of palladium or any other transition-metal catalyst. Excellent sel... Stereocontrolled Synthesis of 5 '- and 6 '-Epimeric Analogues of Muraymycin Nucleoside Antibiotics [作者：SPORK ANATOL P; DUCHO CHRISTIAN,期刊：SYNLETT, 页码：343-346 , 文章类型： Article，,卷期：2013年-3] Naturally occurring nucleoside antibiotics, for example, Streptomyces-produced muraymycins, represent a promising class of potential lead structures for the development of novel antimicrobial agents. The efficient prepar... Mechanistic Insights into Palladium Leaching in Novel Pd/C-Catalyzed Boron-Heck Reaction of Arylboronic Acid [作者：DIGHE MAHESH G; LONKAR SACHIN L; DEGANI MARIAM S,期刊：SYNLETT, 页码：347-350 , 文章类型： Article，,卷期：2013年-3] For the first time, Pd/C has been used for the Boron-Heck reaction, and the detailed mechanistic aspects of the reaction have been proven experimentally by a leaching test as well as by cyclic voltammetry studies. The re... Fast Assembly of 1H-Imidazo[1,2-a]imidazol-5-amines via Groebke-Blackburn-Bienayme Reaction with 2-Aminoimidazoles [作者：PERESHIVKO OLGA P; PESHKOV VSEVOLOD A; ERMOLATEV DENIS S; VAN DER EYCKEN ERIK V,期刊：SYNLETT, 页码：351-354 , 文章类型： Article，,卷期：2013年-3] A novel microwave-assisted protocol allowing the successful application of 2-aminoimidazoles in the Groebke-Blackburn-Bienayme reaction for the facile construction of the 1H-imidazo[1,2-a]imidazol-5-amine core was develo... Palladium-Catalyzed Hydroarylation of Diazoacetic Ester [作者：TITANYUK IGOR D; BELETSKAYA IRINA P,期刊：SYNLETT, 页码：355-358 , 文章类型： Article，,卷期：2013年-3] The novel procedure for the Pd-catalyzed hydroarylation of alpha-diazoacetic ester is reported. In the presence of a catalytic amount of PdCl2(PPh3)(2) the three-component reaction of aryl iodides, ethyl diazoacetate, an...