- Ferritin binds and activates p53 under oxidative stress
[作者:Lee, JH; Jang, H; Cho, EJ; Youn, HD,期刊:Biochemical and Biophysical Research Communications, 页码:399-404 , 文章类型: Article,,卷期:2009年389-3]
- Ferritin, an iron storage protein, plays an essential role in iron homeostasis and a wide range of physiologic processes. Ferritin alleviates oxidative stress by regulating cellular labile iron concentration. The tumor s...
- Ghrelin reverses experimental diabetic neuropathy in mice
[作者:Kyoraku, I; Shiomi, K; Kangawa, K; Nakazato, M,期刊:Biochemical and Biophysical Research Communications, 页码:405-408 , 文章类型: Article,,卷期:2009年389-3]
- Ghrelin, an acylated peptide produced in the stomach, increases food intake and growth hormone secretion, suppresses inflammation and oxidative stress, and promotes cell survival and proliferation. We investigated the ph...
- Erkitinib, a novel EGFR tyrosine kinase inhibitor screened using a ProteoChip system from a phytochemical library
[作者:Kim, EY; Choi, YJ; Park, CW; Kang, IC,期刊:Biochemical and Biophysical Research Communications, 页码:415-419 , 文章类型: Article,,卷期:2009年389-3]
- Receptor tyrosine kinases (PTKs) play key roles in the pathogenesis Of numerous human diseases, including cancer. Therefore PTK inhibitors are currently Under intensive investigation as potential drug candidates. Herein,...
- Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands
[作者:Rullinkov, G; Tamme, R; Sarapuu, A; Lauren, J; Sepp, M; Palm, K; Timmusk, T,期刊:Biochemical and Biophysical Research Communications, 页码:420-425 , 文章类型: Article,,卷期:2009年389-3]
- Delta-Notch signaling is a universal cell-cell communication pathway crucial for numerous developmental and physiological processes. Several proteins interact with and regulate the Notch pathway, including the E3 ubiquit...
- Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems
[作者:Okada, K; Shoda, J; Taguchi, K; Maher, JM; Ishizaki, K; Inoue, Y; Ohtsuki, M; Goto, N; Sugimoto, H; Utsunomiya, H; Oda, K; Warabi, E; Ishii, T; Yamamoto, M,期刊:Biochemical and Biophysical Research Communications, 页码:431-436 , 文章类型: Article,,卷期:2009年389-3]
- The transcription factor Nrf2 is a key regulator for hepatic induction of detoxilying enzymes, antioxidative stress genes and Mrp efflux transporters. We aimed to investigate whether Nrf2 activation counteracts liver inj...
- Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropeptides NPY and AgRP in mice
[作者:Kim, SJ; Lee, SJ; Lee, S; Chae, S; Han, MD; Mar, W; Nam, KW,期刊:Biochemical and Biophysical Research Communications, 页码:437-442 , 文章类型: Article,,卷期:2009年389-3]
- Orexigenic neuropeptides NPY and AgRP play major roles in feeding and are closely related to obesity and diabetic metabolic syndrome. This study explored the inhibitory effect of rutecarpine on feeding and obesity in hig...
- Expression of human beta-defensin-2 gene induced by CpG-DNA in human B cells
[作者:Han, SH; Kim, YE; Park, JA; Park, JB; Kim, YS; Lee, Y; Choi, IG; Kwon, HJ,期刊:Biochemical and Biophysical Research Communications, 页码:443-448 , 文章类型: Article,,卷期:2009年389-3]
- Defensins have a broad range of antimicrobial activity against bacteria, fungi, and viruses. The expression of human beta-defensin-2 (hBD-2) is prevalently observed in epithelial cells and is induced by bacterial infecti...
- The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
[作者:Greggio, E; Taymans, JM; Zhen, EY; Ryder, J; Vancraenenbroeck, R; Beilina, A; Sun, P; Deng, JP; Jaffe, H; Baekelandt, V; Merchant, K; Cookson, MR,期刊:Biochemical and Biophysical Research Communications, 页码:449-454 , 文章类型: Article,,卷期:2009年389-3]
- Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common Cause of inherited Parkinson's disease (PD). The protein is large and complex, but pathogenic mutations cluster in a region containing GTPase and kinase doma...
- Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins
[作者:Wang, RX; He, H; Sun, XJ; Xu, JC; Marshall, FF; Zhau, HY; Chung, LWK; Fu, HA; He, DL,期刊:Biochemical and Biophysical Research Communications, 页码:455-460 , 文章类型: Article,,卷期:2009年389-3]
- We have reported isolation and characterization of the prostate-specific and androgen-regulated PrLZ gene abnormally expressed in prostate cancer. PrLZ is a potential biomarker for prostate cancer and a candidate oncogen...
- Leber's hereditary optic neuropathy is associated with mitochondrial ND6 T14502C mutation
[作者:Zhao, FX; Guan, MQ; Zhou, XT; Yuan, MX; Liang, M; Liu, Q; Liu, Y; Zhang, YM; Yang, L; Tong, Y; Wei, QP; Sun, YH; Qu, J; Guan, MX,期刊:Biochemical and Biophysical Research Communications, 页码:466-472 , 文章类型: Article,,卷期:2009年389-3]
- We repel there the clinical, genetic, and molecular characterization of three Chinese families with Leber's hereditary optic neuropathy (LHON). There were variable severity and age of onset in visual impairment among the...
- Expression of stanniocalcin-1 in gastrointestinal tracts of neonatal and mature rats
[作者:Kobayashi, R; Nakagomi, Y; Shimura, Y; Mochizuki, M; Kobayashi, K; Sugita, K; Ohyama, K,期刊:Biochemical and Biophysical Research Communications, 页码:478-483 , 文章类型: Article,,卷期:2009年389-3]
- Stanniocalcin-1 (STC-1) produced by ovaries endocrinologically targets to mammary glands and is secreted into milk during lactation. The decline of mother's serum level by STC-1 antiserum administration reduced the milk ...
- Inhibition of hepatitis B virus replication with linear DNA sequences expressing antiviral micro-RNA shuttles
[作者:Chattopadhyay, S; Ely, A; Bloom, K; Weinberg, MS; Arbuthnot, P,期刊:Biochemical and Biophysical Research Communications, 页码:484-489 , 文章类型: Article,,卷期:2009年389-3]
- RNA interference (RNAi) may be harnessed to inhibit viral gene expression and this approach is being developed to counter chronic infection with hepatitis B virus (HBV). Compared to synthetic RNAi activators, DNA express...
|