- Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate
[作者：Clarke, R; Cook, KL; Hu, R; Facey, COB; Tavassoly, I; Schwartz, JL; Baumann, WT; Tyson, JJ; Xuan, JH; Wang, Y; Warri, A; Shajahan, AN,期刊：Cancer research, 页码：1321-1331 , 文章类型： Review，,卷期：2012年72-6]
- How breast cancer cells respond to the stress of endocrine therapies determines whether they will acquire a resistant phenotype or execute a cell-death pathway. After a survival signal is successfully executed, a cell mu...
- Acetylation: A Novel Link between Double-Strand Break Repair and Autophagy
[作者：Shubassi, G; Robert, T; Vanoli, F; Minucci, S; Foiani, M,期刊：Cancer research, 页码：1332-1335 , 文章类型： Review，,卷期：2012年72-6]
- Histone deacetylase (HDAC) inhibitors are clinically relevant because they are used as anticancer drugs. Recent evidence sheds light on an intriguing connection among the DNA damage response (DDR), protein acetylation, a...
- Direct Therapeutic Applications of Calcium Electroporation to Effectively Induce Tumor Necrosis
[作者：Frandsen, SK; Gissel, H; Hojman, P; Tramm, T; Eriksen, J; Gehl, J,期刊：Cancer research, 页码：1336-1341 , 文章类型： Article，,卷期：2012年72-6]
- Electroporation of cells with short, high-voltage pikes causes a transient permeabilization of cell membranes that permits passage of otherwise nonpermeating ions and molecules. In this study, we illustrate how electropo...
- Proinflammatory Characteristics of SMAC/DIABLO-Induced Cell Death in Antitumor Therapy
[作者：Emeagi, PU; Van Lint, S; Goyvaerts, C; Maenhout, S; Cauwels, A; McNeish, LA; Bos, T; Heirman, C; Thielennans, K; Aerts, JL; Breckpot, K,期刊：Cancer research, 页码：1342-1352 , 文章类型： Article，,卷期：2012年72-6]
- Molecular mimetics of the caspase activator second mitochondria-derived activator of caspase (SMAC) are being investigated for use in cancer therapy, but an understanding of in vivo effects remains incomplete. In this st...
- Extracellular Matrix Protein CCN1 Limits Oncolytic Efficacy in Glioma
[作者：Haseley, A; Boone, S; Wojton, J; Yu, LB; Yoo, JY; Yu, JH; Kurozurni, K; Glorioso, JC; Caligiuri, MA; Kaur, B,期刊：Cancer research, 页码：1353-1362 , 文章类型： Article，,卷期：2012年72-6]
- Oncolytic viral therapy has been explored widely as an option for glioma treatment but its effectiveness has remained limited. Cysteine rich 61 (CCN1) is an extracellular matrix (ECM) protein elevated in cancer cells tha...
- Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2-mTOR Pathway
[作者：Chen, W; Ma, T; Shen, XN; Xia, XF; Xu, GD; Bai, XI; Liang, TB,期刊：Cancer research, 页码：1363-1372 , 文章类型： Article，,卷期：2012年72-6]
- Tumor-associated macrophages (TAM) have multifaceted roles in tumor development but they have been associated particularly closely with tumor angiogenesis. However, although the accumulation of TAM (M2 phenotype) promote...
- Aptamer-Mediated Blockade of IL4R alpha Triggers Apoptosis of MDSCs and Limits Tumor Progression
[作者：Roth, F; De La Fuente, AC; Vella, JL; Zoso, A; Inverardi, L; Serafini, P,期刊：Cancer research, 页码：1373-1383 , 文章类型： Article，,卷期：2012年72-6]
- In addition to promoting tumor progression and metastasis by enhancing angiogenesis and invasion, myeloid-derived suppressor cells (MDSC) and tumor-associated macrophage (TAM) also inhibit antitumor T-cell functions and ...
- Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition
[作者：Gao, DC; Joshi, N; Choi, HJ; Ryu, SH; Hahn, M; Catena, R; Sadik, H; Argani, P; Wagner, P; Vahdat, LT; Port, JL; Stiles, B; Sukumar, S; Altorki, NK; Rafii, S; Mittal, V,期刊：Cancer research, 页码：1384-1394 , 文章类型： Article，,卷期：2012年72-6]
- Tumors systemically initiate metastatic niches in distant target metastatic organs. These niches, composed of bone marrow-derived hematopoietic cells, provide permissive conditions for future metastases. however, the mec...
- Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma
[作者：Corre, J; Labat, E; Espagnolle, N; Hebraud, B; Avet-Loiseau, H; Roussel, M; Huynh, A; Gadelorge, M; Cordelier, P; Klein, B; Moreau, P; Facon, T; Fournie, JJ; Attal, M; Bourin, P,期刊：Cancer research, 页码：1395-1406 , 文章类型： Article，,卷期：2012年72-6]
- Overexpression of growth differentiation factor 15 (GDF15) by bone marrow mesenchymal stern cells occurs widely in patients with multiple myeloma, but the pathophysiologic effects of GDF15 in this setting remain undefine...
- Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity
[作者：Pietra, G; Manzini, C; Rivara, S; Vitale, M; Cantoni, C; Petretto, A; Balsamo, M; Conte, R; Benelli, R; Minghelli, S; Solari, N; Gualco, M; Queirolo, P; Moretta, L; Mingari, MC,期刊：Cancer research, 页码：1407-1415 , 文章类型： Article，,卷期：2012年72-6]
- Natural killer (NK) cells play a key role in tumor immune surveillance. However, adoptive immunotherapy protocols using NK cells have shown limited clinical efficacy to date, possibly due to tumor escape mechanisms that ...
- Leptin Mediates Tumor-Stromal Interactions That Promote the Invasive Growth of Breast Cancer Cells
[作者：Barone, I; Catalano, S; Gelsomino, L; Marsico, S; Giordano, C; Panza, S; Bonofiglio, D; Bossi, G; Covington, KR; Fuqua, SAW; Ando, S,期刊：Cancer research, 页码：1416-1427 , 文章类型： Article，,卷期：2012年72-6]
- Obesity confers risks to cancer development and progression but the mechanisms underlying these risks remain unclear. In this study, we identify a role for the obesity cytokine leptin, which has been implicated previousl...
- Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin alpha 6 beta 1 in Glioblastoma
[作者：Huang, P; Rani, MRS; Ahluwalia, MS; Bae, E; Prayson, RA; Weil, RJ; Nowacki, AS; Hedayat, H; Sloan, AE; Lathia, JD; Rich, JN; Tibbs, R; Gladson, CL,期刊：Cancer research, 页码：1428-1437 , 文章类型： Article，,卷期：2012年72-6]
- Activation of TNF receptor 1 (TNF-) can generate signals that promote either apoptosis or survival. In this study, we show that these signals can be determined by the character of the extra.cellular matrix in the tumor m...
- Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells
[作者：Tamada, M; Nagano, O; Tateyama, S; Ohmura, M; Yae, T; Ishimoto, T; Sugihara, E; Onishi, N; Yamamoto, T; Yanagawa, H; Suematsu, M; Saya, H,期刊：Cancer research, 页码：1438-1448 , 文章类型： Article，,卷期：2012年72-6]
- An increased glycolytic flux accompanied by activation of the pentose phosphate pathway (PPP) is implicated in chemoresistance of cancer cells. In this study, we found that CD44, a cell surface marker for cancer stem cel...
- CD44 Proteolysis Increases CREB Phosphorylation and Sustains Proliferation of Thyroid Cancer Cells
[作者：De Falco, V; Tamburrino, A; Ventre, S; Castellone, MD; Malek, M; Manie, SN; Santoro, M,期刊：Cancer research, 页码：1449-1458 , 文章类型： Article，,卷期：2012年72-6]
- CD44 is a marker of cancer stem-like cells and epithelial-mesenchymal transition that is overexpressed in many cancer types, including thyroid carcinoma. At extracellular and intramembranous domains, CD44 undergoes seque...
- Dietary Cadmium Exposure and Risk of Postmenopausal Breast Cancer: A Population-Based Prospective Cohort Study
[作者：Julin, B; Wolk, A; Bergkvist, L; Bottai, M; Akesson, A,期刊：Cancer research, 页码：1459-1466 , 文章类型： Article，,卷期：2012年72-6]
- The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure ...
- 3 '-UTR and Functional Secretor Haplotypes in Mannose-Binding Lectin 2 Are Associated with Increased Colon Cancer Risk in African Americans
[作者：Zanetti, KA; Haznadar, M; Welsh, JA; Robles, AI; Ryan, BM; McClary, AC; Bowman, ED; Goodman, JE; Bernig, T; Chanock, SJ; Harris, CC,期刊：Cancer research, 页码：1467-1477 , 文章类型： Article，,卷期：2012年72-6]
- Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer s...
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