- The Insulin-Like Growth Factor Receptor I Promotes Motility and Invasion of Bladder Cancer Cells through Akt- and Mitogen-Activated Protein Kinase-Dependent Activation of Paxillin
[作者：Metalli, D; Lovat, F; Tripodi, F; Genua, M; Xu, SQ; Spinelli, M; Alberghina, L; Vanoni, M; Baffa, R; Gomella, LG; Iozzo, RV; Morrione, A,期刊：American Journal of Pathology, 页码：2997-3006 , 文章类型： Article，,卷期：2010年176-6]
- The insulin-like growth factor receptor I (IGF-IR) plays an essential role in transformation by promoting cell growth and protecting cancer cells from apoptosis. Aberrant IGF-IR signaling is implicated in several types o...
- Overexpression of Galectin-7, A Myoepithelial Cell Marker, Enhances Spontaneous Metastasis of Breast Cancer Cells
[作者：Demers, M; Rose, AAN; Grosset, AA; Biron-Pain, K; Gaboury, L; Siegel, PM; St-Pierre, Y,期刊：American Journal of Pathology, 页码：3023-3031 , 文章类型： Article，,卷期：2010年176-6]
- Galectins are members of a family of beta-galactosidesbinding proteins that have recently emerged as novel modulators in different aspects of cancer. The expression of galectins in tumors and/or the tissue surrounding th...
- Podocalyxin EBP50 Ezrin Molecular Complex Enhances the Metastatic Potential of Renal Cell Carcinoma Through Recruiting Rac1 Guanine Nucleotide Exchange Factor ARHGEF7
[作者：Hsu, YH; Lin, WL; Hou, YT; Pu, YS; Shun, CT; Chen, CL; Wu, YY; Chen, JY; Chen, TH; Jou, TS,期刊：American Journal of Pathology, 页码：3050-3061 , 文章类型： Article，,卷期：2010年176-6]
- Podocalyxin was initially identified in glomerular podocytes to critically maintain the structural and functional integrity of the glomerular ultrafiltrative apparatus. Lately, it has emerged as a malignant marker in tum...
- Pathogenesis of Middle Ear Cholesteatoma A New Model of Experimentally Induced Cholesteatoma in Mongolian Gerbils
[作者：Yamamoto-Fukuda, T; Hishikawa, Y; Shibata, Y; Kobayashi, T; Takahashi, H; Koji, T,期刊：American Journal of Pathology, 页码：2602-2606 , 文章类型： Article，,卷期：2010年176-6]
- Middle ear cholesteatoma is characterized by enhanced proliferation of epithelial cells with aberrant morphological characteristics. To investigate the origin of the cholesteatoma cells, we analyzed spontaneously occurri...
- A Rat Model for Choroidal Neovascularization Using Subretinal Lipid Hydroperoxide Injection
[作者：Baba, T; Bhutto, IA; Merges, C; Grebe, R; Emmert, D; McLeod, DS; Armstrong, D; Lutty, GA,期刊：American Journal of Pathology, 页码：3085-3097 , 文章类型： Article，,卷期：2010年176-6]
- The purpose of this study was to develop and characterize a rat model of choroidal neovascularization (CNV) as occurs in age-related macular degeneration. The lipid hydroperoxide 13(S)-hydroperoxy-9Z,11E-octadecadienoic ...
- The Association of CCND1 Overexpression and Cisplatin Resistance in Testicular Germ Cell Tumors and Other Cancers
[作者：Noel, EE; Yeste-Velasco, M; Mao, XY; Perry, J; Kudahetti, SC; Li, NF; Sharp, S; Chaplin, T; Xue, LY; McIntyre, A; Shan, L; Powles, T; Oliver, RTD; Young, BD; Shipley, J; Berney, DM; Joel, SP; Lu, YJ,期刊：American Journal of Pathology, 页码：2607-2615 , 文章类型： Article，,卷期：2010年176-6]
- Development of chemoresistance limits the clinical efficiency of platinum-based therapy. Although many resistance mechanisms have been demonstrated, genetic/molecular alterations responsible for drug resistance in the ma...
- 2p24 Gain Region Harboring MYCN Gene Compared with MYCN Amplified and Nonamplified Neuroblastoma Biological and Clinical Characteristics
[作者：Jeison, M; Ash, S; Halevy-Berko, G; Mardoukh, J; Luria, D; Avigad, S; Feinberg-Gorenshtein, G; Goshen, Y; Hertzel, G; Kapelushnik, J; Ben Barak, AL; Attias, D; Steinberg, R; Stein, J; Stark, B; Yaniv, I,期刊：American Journal of Pathology, 页码：2616-2625 , 文章类型： Article，,卷期：2010年176-6]
- Although the role of MYCN amplification in neuroblastoma is well established, the biological and clinical characteristics of the 2p gain region harboring the MYCN gene remain unclear. The aim of this study was to compare...
- Pathologic Caveolin-1 Regulation of PTEN in Idiopathic Pulmonary Fibrosis
[作者：Xia, H; Khalil, W; Kahm, J; Jessurun, J; Kleidon, J; Henke, CA,期刊：American Journal of Pathology, 页码：2626-2637 , 文章类型： Article，,卷期：2010年176-6]
- Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disorder refractory to current pharmacological therapies. Fibroblasts isolated from IPF patients display pathological activation of PI3K/Akt caused ...
- Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2
[作者：Derbali, H; Bosse, Y; Cote, N; Pibarot, P; Audet, A; Pepin, A; Arsenault, B; Couture, C; Despres, JP; Mathieu, P,期刊：American Journal of Pathology, 页码：2638-2645 , 文章类型： Article，,卷期：2010年176-6]
- Aortic stenosis (AS) is the most common valvular heart disease, and it is suspected that atherosclerotic mechanisms are involved in the development of this disorder. Therefore, the retention of lipids within the aortic v...
- Loss of Negative Feedback Control of Nuclear Factor-kappa B2 Activity in Lymphocytes Leads to Fatal Lung Inflammation
[作者：Yang, LQ; Cui, HJ; Wang, Z; Zhang, BC; Ding, J; Liu, L; Ding, HF,期刊：American Journal of Pathology, 页码：2646-2657 , 文章类型： Article，,卷期：2010年176-6]
- Proteolytic processing of the nuclear factor (NF)-kappa B2 precursor protein p100 generates the active NF-kappa B2 subunit p52, which in turn transcriptionally up-regulates p100 expression. p100 also functions as an I ka...
- A Highly Toxic Cellular Prion Protein Induces a Novel, Nonapoptotic Form of Neuronal Death
[作者：Christensen, HM; Dikranian, K; Li, AM; Baysac, KC; Walls, KC; Olney, JW; Roth, KA; Harris, DA,期刊：American Journal of Pathology, 页码：2695-2706 , 文章类型： Article，,卷期：2010年176-6]
- Several different deletions within the N-terminal tail of the prion protein (PrP) induce massive neuronal death when expressed in transgenic mice. This toxicity is dose-dependently suppressed by coexpression of full-leng...
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