- Flaky Tail Mouse Denotes Human Atopic Dermatitis in the Steady State and by Topical Application with Dermatophagoides pteronyssinus Extract
[作者：Moniaga, CS; Egawa, G; Kawasaki, H; Hara-Chikuma, M; Honda, T; Tanizaki, H; Nakajima, S; Otsuka, A; Matsuoka, H; Kubo, A; Sakabe, J; Tokura, Y; Miyachi, Y; Amagai, M; Kabashima, K,期刊：American Journal of Pathology, 页码：2385-2393 , 文章类型： Article，,卷期：2010年176-5]
- The barrier abnormality, a loss-of-function mutation In the gene encoding filaggrin (FLG), which is linked to the incidence of atopic dermatitis (AD), is a recently discovered but important factor in the pathogenesis of ...
- Critical Roles of Lysosomal Acid Lipase in Myelopoiesis
[作者：Qu, P; Shelley, WC; Yoder, MC; Wu, LY; Du, H; Yan, C,期刊：American Journal of Pathology, 页码：2394-2404 , 文章类型： Article，,卷期：2010年176-5]
- Lysosomal acid lipase (LAL) is a key enzyme that cleaves cholesteryl esters and triglycerides to generate free fatty acids and cholesterol in lysosomes. Genetic ablation of the lal gene (lal(-/-)) in mice has resulted in...
- Genetic Background Affects Properties of Satellite Cells and mdx Phenotypes
[作者：Fukada, S; Morikawa, D; Yamamoto, Y; Yoshida, T; Sumie, N; Yamaguchi, M; Ito, T; Miyagoe-Suzuki, Y; Takeda, S; Tsujikawa, K; Yamamoto, H,期刊：American Journal of Pathology, 页码：2414-2424 , 文章类型： Article，,卷期：2010年176-5]
- Duchenne muscular dystrophy (DMD) is the most common lethal genetic disorder of children. The mdx (C57BL/10 background, C57BL/10-mdx) mouse is a widely used model of DMD, but the histopathological hallmarks of DMD, such ...
- CXCR3/Ligands Are Significantly Involved in the Tumorigenesis of Basal Cell Carcinomas
[作者：Lo, BKK; Yu, M; Zloty, D; Cowan, B; Shapiro, J; McElwee, KJ,期刊：American Journal of Pathology, 页码：2435-2446 , 文章类型： Article，,卷期：2010年176-5]
- Basal cell carcinoma (BCC) is the most common skin malignancy encountered worldwide. We hypothesized that CXC chemokines, small cytokines involved in inducing directed leukocyte chemotaxis, could play a key role in the m...
- Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice
[作者：Murphy, KT; Ryall, JG; Snell, SM; Nair, L; Koopman, R; Krasney, PA; Ibebunjo, C; Holden, KS; Loria, PM; Salatto, CT; Lynch, GS,期刊：American Journal of Pathology, 页码：2425-2434 , 文章类型： Article，,卷期：2010年176-5]
- Duchenne muscular dystrophy (DMD) is characterized by progressive skeletal muscle wasting and weakness, leading to premature death from respiratory and/or cardiac failure. A clinically relevant question is whether myosta...
- Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells
[作者：Liu, YL; Xiang, XY; Zhuang, XY; Zhang, SY; Liu, CR; Cheng, ZQ; Michalek, S; Grizzle, W; Zhang, HG,期刊：American Journal of Pathology, 页码：2490-2499 , 文章类型： Article，,卷期：2010年176-5]
- In this study we observed that mice pretreated with tumor exosomes had a significant acceleration of tumor metastasis in the lung. Tumor metastasis correlated significantly with an increase in recruitment of more Myeloid...
- The NADPH Oxidase Subunit p22(phox) Inhibits the Function of the Tumor Suppressor Protein Tuberin
[作者：Block, K; Gorin, Y; New, DD; Eid, A; Chelmicki, T; Reed, A; Choudhury, GG; Parekh, DJ; Abboud, HE,期刊：American Journal of Pathology, 页码：2447-2455 , 文章类型： Article，,卷期：2010年176-5]
- Mutations in the von Hippel-Lindau (VHL) gene give rise to renal cell carcinoma. Reactive oxygen species, generated by Nox oxidases, are involved in tumorigenesis. We have previously demonstrated that in VHL-deficient ce...
- MicroRNA-193b Represses Cell Proliferation and Regulates Cyclin D1 in Melanoma
[作者：Chen, JM; Feilotter, HE; Pare, GC; Zhang, XA; Pemberton, JGW; Garady, C; Lai, D; Yang, XL; Tron, VA,期刊：American Journal of Pathology, 页码：2520-2529 , 文章类型： Article，,卷期：2010年176-5]
- Cutaneous melanoma is an aggressive form of human skin cancer characterized by high metastatic potential and poor prognosis. To better understand the role of microRNAs (miRNAs) in melanoma, the expression of 470 miRNAs w...
- Reduction of IKK alpha Expression Promotes Chronic Ultraviolet B Exposure-Induced Skin Inflammation and Carcinogenesis
[作者：Xia, XJ; Park, E; Liu, BG; Willette-Brown, J; Gong, WH; Wang, JM; Mitchell, D; Fischer, SM; Hu, YL,期刊：American Journal of Pathology, 页码：2500-2508 , 文章类型： Article，,卷期：2010年176-5]
- Ultraviolet B light (UVB) is a common cause of human skin cancer. UVB irradiation induces mutations in the tumor suppressor p53 gene as well as chronic inflammation, which are both essential for UVB carcinogenesis. Inhib...
- Desmosomal Plakophilins in the Prostate and Prostatic Adenocarcinomas Implications for Diagnosis and Tumor Progression
[作者：Breuninger, S; Reidenbach, S; Sauer, CG; Strobel, P; Pfitzenmaier, J; Trojan, L; Hofmann, I,期刊：American Journal of Pathology, 页码：2509-2519 , 文章类型： Article，,卷期：2010年176-5]
- The plakophilins, members of the armadillo-repeat family, consist of three different proteins (PKP1-3) that are specifically recruited to desmosomal plaques in a highly cell type-specific manner. Using immunofluorescence...
- Cathepsin L in Bone Marrow-Derived Cells Is Required for Retinal and Choroidal Neovascularization
[作者：Shimada, N; Ohno-Matsui, K; Iseki, S; Koike, M; Uchiyama, Y; Wang, JY; Yoshida, T; Sato, T; Peters, C; Mochizuki, M; Morita, I,期刊：American Journal of Pathology, 页码：2571-2580 , 文章类型： Article，,卷期：2010年176-5]
- Many vision-threatening diseases are characterized by intraocular neovascularization, (e.g., proliferative diabetic retinopathy and age-related macular degeneration). Although a new therapy with anti-VEGF antibodies is b...
- Overexpression of Bcl-2 in Vascular Endothelium Inhibits the Microvascular Lesions of Diabetic Retinopathy
[作者：Kern, TS; Du, YP; Miller, CM; Hatala, DA; Levin, LA,期刊：American Journal of Pathology, 页码：2550-2558 , 文章类型： Article，,卷期：2010年176-5]
- Recent studies on the pathogenesis of diabetic retinopathy have focused on correcting adverse biochemical alterations, but there have been fewer efforts to enhance prosurvival pathways. Bcl-2 is the archetypal member of ...
- Diagnostic Utility of Galectin-3 in Thyroid Cancer
[作者：Chiu, CG; Strugnell, SS; Griffith, OL; Jones, SJM; Gown, AM; Walker, B; Nabi, IR; Wiseman, SM,期刊：American Journal of Pathology, 页码：2067-2081 , 文章类型： Review，,卷期：2010年176-5]
- Galectin-3 (Gal-3), which has received significant recent attention for its utility as a diagnostic marker for thyroid cancer, represents the most well-studied molecular candidate for thyroid cancer diagnosis. Gal-3 is a...
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