- Progressive Secondary Neurodegeneration and Microcalcification Co-Occur in Osteopontin-Deficient Mice
[作者:Maetzler, W; Berg, D; Funke, C; Sandmann, F; Stunitz, H; Maetzler, C; Nitsch, C,期刊:American Journal of Pathology, 页码:829-839 , 文章类型: Article,,卷期:2010年177-2]
- In the brain, osteopontin (OPN) may function in a variety of pathological conditions, including neurodegeneration, microcalcification, and inflammation. In this study, we addressed the role of OPN in primary and secondar...
- Gastrointestinal Tract Disorder in Natriuretic Peptide Receptor B Gene Mutant Mice
[作者:Sogawa, C; Abe, A; Tsuji, T; Koizumi, M; Saga, T; Kunieda, T,期刊:American Journal of Pathology, 页码:822-828 , 文章类型: Article,,卷期:2010年177-2]
- Natriuretic peptide receptor B (NPR-B), which has high affinity for C-type natriuretic peptide (CNP) and synthesizes intracellular cGMP, may be involved in gastrointestinal tract (GIT) regulation. A mutant allele of the ...
- Loss of Estrogen Receptor 1 Enhances Cervical Cancer Invasion
[作者:Zhai, YL; Bommer, GT; Feng, Y; Wiese, AB; Fearon, ER; Cho, KR,期刊:American Journal of Pathology, 页码:884-895 , 文章类型: Article,,卷期:2010年177-2]
- If left untreated, some cervical high-grade squamous intraepithelial lesions will progress to invasive squamous cell carcinoma (SCC), but the molecular events conferring invasive potential remain poorly defined. In prior...
- Engraftment of Cells from Porcine Islets of Langerhans and Normalization of Glucose Tolerance Following Transplantation of Pig Pancreatic Primordia in Nonimmune-Suppressed Diabetic Rats
[作者:Rogers, SA; Mohanakumar, T; Liapis, H; Hammerman, MR,期刊:American Journal of Pathology, 页码:854-864 , 文章类型: Article,,卷期:2010年177-2]
- Transplantation therapy for human diabetes is limited by the toxicity of immunosuppressive drugs. However, even if toxicity can be minimalized, there will still be a shortage of human donor organs. Xenotransplantation of...
- Polo-Like Kinase 1 as Predictive Marker and Therapeutic Target for Radiotherapy in Rectal Cancer
[作者:Rodel, F; Keppner, S; Capalbo, G; Bashary, R; Kaufmann, M; Rodel, C; Strebhardt, K; Spankuch, B,期刊:American Journal of Pathology, 页码:918-929 , 文章类型: Article,,卷期:2010年177-2]
- The ability to predict tumor sensitivity toward radiotherapy may significantly impact the selection of patients for preoperative combined-modality therapy. The aim of the present study was to test the predictive value of...
- Deregulated Expression of the Polycomb-Group Protein SUZ12 Target Genes Characterizes Mantle Cell Lymphoma
[作者:Martin-Perez, D; Sanchez, E; Maestre, L; Suela, J; Vargiu, P; Di Lisio, L; Martinez, N; Alves, J; Piris, MA; Sanchez-Beato, M,期刊:American Journal of Pathology, 页码:930-942 , 文章类型: Article,,卷期:2010年177-2]
- Polycomb proteins are known to be of great importance in human cancer pathogenesis. SUZ12 is a component of the Polycomb PRC2 complex that, along with EZH2, is involved in embryonic stem cell differentiation. EZH2 plays ...
- Identification of a Structural Motif in the Tumor-Suppressive Protein GRIM-19 Required for Its Antitumor Activity
[作者:Nallar, SC; Kalakonda, S; Sun, P; Ohmori, Y; Hiroi, M; Mori, K; Lindner, DJ; Kalvakolanu, DV,期刊:American Journal of Pathology, 页码:896-907 , 文章类型: Article,,卷期:2010年177-2]
- We have previously isolated GRIM-19, a novel growth suppressor, using a genetic method. GRIM-19 ablates cell growth by inhibiting the transcription factor signal transducer and activator of transcription 3 (STAT3). Up-re...
- Role of ES Cell-Expressed Ras (ERas) in Tumorigenicity of Gastric Cancer
[作者:Kubota, E; Kataoka, H; Aoyama, M; Mizoshita, T; Mori, Y; Shimura, T; Tanaka, M; Sasaki, M; Takahashi, S; Asai, K; Joh, T,期刊:American Journal of Pathology, 页码:955-963 , 文章类型: Article,,卷期:2010年177-2]
- ERas, a unique member of the Ras family, was initially found only in embryonic stem (ES) cells, where it plays a crucial role in the transformation of transplanted ES cells to teratomas. ERas is involved in ES cell survi...
- Tumor Necrosis Factor Receptor Expression and Signaling in Renal Cell Carcinoma
[作者:Al-Lamki, RS; Sadler, TJ; Wang, J; Reid, MJ; Warren, AY; Movassagh, M; Lu, WH; Mills, IG; Neal, DE; Burge, J; Vandenebeele, P; Pober, JS; Bradley, JR,期刊:American Journal of Pathology, 页码:943-954 , 文章类型: Article,,卷期:2010年177-2]
- Clear cell renal cell carcinoma (ccRCC), a tubular epithelial cell (TEC) malignancy, frequently secretes tumor necrosis factor (TNF). TNF signals via two distinct receptors (TNFRs). TNFR1, expressed in normal kidney prim...
- Tumor Lymphangiogenesis and Metastasis to Lymph Nodes Induced by Cancer Cell Expression of Podoplanin
[作者:Cueni, LN; Hegyi, I; Shin, JW; Albinger-Hegyi, A; Gruber, S; Kunstfeld, R; Moch, H; Detmar, M,期刊:American Journal of Pathology, 页码:1004-1016 , 文章类型: Article,,卷期:2010年177-2]
- The membrane glycoprotein podoplanin is expressed by several types of human cancers and might be associated with their malignant progression. Its exact biological function and molecular targets are unclear, however. Here...
- Vascular-Leukocyte Interactions Mechanisms of Human Decidual Spiral Artery Remodeling in Vitro
[作者:Hazan, AD; Smith, SD; Jones, RL; Whittle, W; Lye, SJ; Dunk, CE,期刊:American Journal of Pathology, 页码:1017-1030 , 文章类型: Article,,卷期:2010年177-2]
- Transformation of uterine spiral arteries is critical for healthy human pregnancy. We recently proposed a role for maternal leukocytes in decidual spiral artery remodeling and suggested that matrix metalloprotease (MMP) ...
- Mast Cells Are Novel Independent Prognostic Markers in Prostate Cancer and Represent a Target for Therapy
[作者:Johansson, A; Rudolfsson, S; Hammarsten, P; Halin, S; Pietras, K; Jones, J; Stattin, P; Egevad, L; Granfors, T; Wikstrom, P; Bergh, A,期刊:American Journal of Pathology, 页码:1031-1041 , 文章类型: Article,,卷期:2010年177-2]
- Mast cells affect growth in various human tumors, but their role in prostate cancer (PC) is unclear. Here, we identify mast cells as independent prognostic markers in PC using a large cohort of untreated PC patients with...
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