- Rheumatoid arthritis and pregnancy: Disease activity, pregnancy outcomes, and treatment options during pregnancy and lactation
[作者:Gogia, M; Furst, DE,期刊:Drug Development Research, 页码:689-702 , 文章类型: Article,,卷期:2011年72-8]
- The present work reviews the available data on rheumatoid arthritis (RA) during pregnancy and the postpartum period. The data generally support some improvement in RA during pregnancy, but these data are not consistent, ...
- Nanomedicine development for autoimmune diseases
[作者:Yuan, F; Thiele, GM; Wang, D,期刊:Drug Development Research, 页码:703-716 , 文章类型: Article,,卷期:2011年72-8]
- Autoimmune diseases result from a dysfunctional immune system in which the body attacks its own organs, tissues, cells, and macromolecules. This group of diseases consists of more than 80 chronic diseases that often lead...
- Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for the treatment of autoimmune disorders
[作者:Tanaka, T; Hagihara, K; Shima, Y; Narazaki, M; Ogata, A; Kumanogoh, A,期刊:Drug Development Research, 页码:717-732 , 文章类型: Article,,卷期:2011年72-8]
- The cytokine interleukin (IL)-6 has a wide range of biological activities. It contributes to host defense against pathogens by inducing immune responses, hematopoiesis, and acute-phase reactions. However, dysregulation o...
- Azathioprine in ulcerative colitis: Why, when, how and how long to use it
[作者:Ribeiro, TCD; Chebli, LA; Gaburri, PD; Chebli, JMF,期刊:Drug Development Research, 页码:733-738 , 文章类型: Article,,卷期:2011年72-8]
- Ulcerative colitis (UC) is a lifelong, immune-mediated inflammatory condition of the colonic mucosa characterized by a relapsing and remitting course. The mainstay of treatment used to be the 5-aminosalicylates (5-ASA) a...
- Bosentan treatment of digital ulcers related to autoimmune disorders
[作者:Cantisani, C; Mattozzi, C; Giancristoforo, S; D'Epiro, S; Richetta, AG,期刊:Drug Development Research, 页码:750-755 , 文章类型: Article,,卷期:2011年72-8]
- Endothelin 1, a powerful endogenous vasoconstrictor and mitogen, may be causal to pulmonary hypertension. Evidence also suggests that endothelin (ET) may have a fundamental role in scleroderma pathogenesis, including pul...
- Potential for phosphodiesterase inhibitors in the management of autoimmune diseases
[作者:Shenoy, P; Agarwal, V; Agarwal, A; Misra, R; Naik, S,期刊:Drug Development Research, 页码:772-778 , 文章类型: Article,,卷期:2011年72-8]
- Phosphodiesterases (PDEs) and their substrates, cAMP and cGMP, are ubiquitously expressed in the immune system. Inhibiting PDEs may represent a novel approach for regulating immune functions and have a therapeutic potent...
- Beyond transitional selection: New roles for BLyS in peripheral tolerance
[作者:Oropallo, MA; Kiefer, K; Marshak-Rothstein, A; Cancro, MP,期刊:Drug Development Research, 页码:779-787 , 文章类型: Article,,卷期:2011年72-8]
- B-cell targeted therapies have enjoyed recent success in the treatment of systemic autoimmune diseases. Among these, Belimumab, which blocks the B-cell survival cytokine BLyS, was recently approved for the treatment of s...
|