- Detailed Structural-Functional Analysis of the Kruppel-like Factor 16 (KLF16) Transcription Factor Reveals Novel Mechanisms for Silencing Sp/KLF Sites Involved in Metabolism and Endocrinology
[作者:Daftary, GS; Lomberk, GA; Buttar, NS; Allen, TW; Grzenda, A; Zhang, JS; Zheng, Y; Mathison, AJ; Gada, RP; Calvo, E; Iovanna, JL; Billadeau, DD; Prendergast, FG; Urrutia, R,期刊:Journal of Biological Chemistry, 页码:7010-7025 , 文章类型: Article,,卷期:2012年287-10]
- Kruppel-like factor (KLF) proteins have elicited significant attention due to their emerging key role in metabolic and endocrine diseases. Here, we extend this knowledge through the biochemical characterization of KLF16,...
- Interactions Between beta-Catenin and Transforming Growth Factor-beta Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP)
[作者:Zhou, BY; Liu, YX; Kahn, M; Ann, DK; Han, A; Wang, HJ; Nguyen, C; Flodby, P; Zhong, Q; Krishnaveni, MS; Liebler, JM; Minoo, P; Crandall, ED; Borok, Z,期刊:Journal of Biological Chemistry, 页码:7026-7038 , 文章类型: Article,,卷期:2012年287-10]
- Interactions between transforming growth factor-beta (TGF-beta) and Wnt are crucial to many biological processes, although specific targets, rationale for divergent outcomes (differentiation versus block of epithelial pr...
- Phosphorylation of alpha-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property in Caenorhabditis elegans
[作者:Kuwahara, T; Tonegawa, R; Ito, G; Mitani, S; Iwatsubo, T,期刊:Journal of Biological Chemistry, 页码:7098-7109 , 文章类型: Article,,卷期:2012年287-10]
- alpha-Synuclein is causative for autosomal dominant familial Parkinson disease and dementia with Lewy bodies, and the phosphorylation of alpha-synuclein at residue Ser-129 is a key posttranslational modification detected...
- Synergistic Roles for G-protein gamma(3) and gamma(7) Subtypes in Seizure Susceptibility as Revealed in Double Knock-out Mice
[作者:Schwindinger, WF; Mirshahi, UL; Baylor, KA; Sheridan, KM; Stauffer, AM; Usefof, S; Stecker, MM; Mirshahi, T; Robishaw, JD,期刊:Journal of Biological Chemistry, 页码:7121-7133 , 文章类型: Article,,卷期:2012年287-10]
- The functions of differentG-protein alpha beta gamma subunit combinations are traditionally ascribed to their various alpha components. However, the discovery of similarly diverse gamma subtypes raises the possibility th...
- A Conserved Lipid-binding Loop in the Kindlin FERM F1 Domain Is Required for Kindlin-mediated alpha IIb beta 3 Integrin Coactivation
[作者:Bouaouina, M; Goult, BT; Huet-Calderwood, C; Bate, N; Brahme, NN; Barsukov, IL; Critchley, DR; Calderwood, DA,期刊:Journal of Biological Chemistry, 页码:6979-6990 , 文章类型: Article,,卷期:2012年287-10]
- The activation of heterodimeric integrin adhesion receptors from low to high affinity states occurs in response to intracellular signals that act on the short cytoplasmic tails of integrin beta subunits. Binding of the t...
- Regulation of Insulin Signaling and Glucose Transporter 4 (GLUT4) Exocytosis by Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) Phosphatase, Skeletal Muscle, and Kidney Enriched Inositol Polyphosphate Phosphatase (SKIP)
[作者:Ijuin, T; Takenawa, T,期刊:Journal of Biological Chemistry, 页码:6991-6999 , 文章类型: Article,,卷期:2012年287-10]
- The glucose transporter 4 (GLUT4) is responsible for glucose uptake in the skeletal muscle. Insulin-induced translocation of GLUT4 to the plasma membrane requires phosphatidylinositol 3-kinase activation-mediated generat...
- The Signaling Protein CD38 Is Essential for Early Embryonic Development
[作者:Churamani, D; Geach, TJ; Ramakrishnan, L; Prideaux, N; Patel, S; Dale, L,期刊:Journal of Biological Chemistry, 页码:6974-6978 , 文章类型: Article,,卷期:2012年287-10]
- CD38 is a multifunctional protein possessing ADP-ribosyl cyclase activity responsible for both the synthesis and the degradation of several Ca2+-mobilizing second messengers. Although a variety of functions have been asc...
- Structural Insights into Apoptotic DNA Degradation by CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans
[作者:Lin, JLJ; Nakagawa, A; Lin, CL; Hsiao, YY; Yang, WZ; Wang, YT; Doudeva, LG; Skeen-Gaar, RR; Xue, D; Yuan, HNS,期刊:Journal of Biological Chemistry, 页码:7110-7120 , 文章类型: Article,,卷期:2012年287-10]
- Endonuclease G (EndoG) is a mitochondrial protein that traverses to the nucleus and participates in chromosomal DNA degradation during apoptosis in yeast, worms, flies, and mammals. However, it remains unclear how EndoG ...
- Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-Dithiol-Iron Complexes: Long-lived NO That Is Trafficked by Interacting Proteins
[作者:Rahmanto, YS; Kalinowski, DS; Lane, DJR; Lok, HC; Richardson, V; Richardson, DR,期刊:Journal of Biological Chemistry, 页码:6960-6968 , 文章类型: Review,,卷期:2012年287-10]
- Nitrogen monoxide (NO) markedly affects intracellular iron metabolism, and recent studies have shown that molecules traditionally involved in drug resistance, namely GST and MRP1 (multidrug resistance-associated protein ...
- Structure-guided Engineering Enhances a Phytochrome-based Infrared Fluorescent Protein
[作者:Auldridge, ME; Satyshur, KA; Anstrom, DM; Forest, KT,期刊:Journal of Biological Chemistry, 页码:7000-7009 , 文章类型: Article,,卷期:2012年287-10]
- Phytochrome is a multidomain dimeric red light photoreceptor that utilizes a chromophore-binding domain (CBD), a PHY domain, and an output module to induce cellular changes in response to light. A promising biotechnology...
- A Blood Fluke Serine Protease Inhibitor Regulates an Endogenous Larval Elastase
[作者:Quezada, LAL; Sajid, M; Lim, KC; McKerrow, JH,期刊:Journal of Biological Chemistry, 页码:7074-7083 , 文章类型: Article,,卷期:2012年287-10]
- The larvae of Schistosoma mansoni invade their mammalian host by utilizing a serine protease, cercarial elastase (SmCE), to degrade macromolecular proteins in host skin. The catalytic activity of serine and cysteine prot...
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