- Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis
[作者:Li, Y; Ye, X; Tan, C; Hongo, JA; Zha, J; Liu, J; Kallop, D; Ludlam, MJC; Pei, L,期刊:Oncogene, 页码:3442-3455 , 文章类型: Article,,卷期:2009年28-39]
- Dysregulation of Axl and its ligand growth arrest-specific 6 is implicated in the pathogenesis of several human cancers. In this study, we have used RNAi and monoclonal antibodies to assess further the oncogenic potentia...
- Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence
[作者:Helmbold, H; Komm, N; Deppert, W; Bohn, W,期刊:Oncogene, 页码:3456-3467 , 文章类型: Article,,卷期:2009年28-39]
- The different pocket proteins are established as negative cell cycle regulators. With regard to the repressor functions of pocket proteins in cellular senescence, studies so far have mainly focused on pRb/p105. Here, we ...
- Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival
[作者:Sarangi, A; Valadez, JG; Rush, S; Abel, TW; Thompson, RC; Cooper, MK,期刊:Oncogene, 页码:3468-3476 , 文章类型: Article,,卷期:2009年28-39]
- Hedgehog pathway activity has been demonstrated in malignant glioma. However, its role in tumor growth has not been determined. Here we demonstrate that pharmacological inhibition of the Hedgehog pathway in established o...
- Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation
[作者:Novosyadlyy, R; Vijayakumar, A; Lann, D; Fierz, Y; Kurshan, N; LeRoith, D,期刊:Oncogene, 页码:3477-3486 , 文章类型: Article,,卷期:2009年28-39]
- Polyoma virus middle T antigen (PyVmT) is a powerful viral oncogene; however, the mechanisms of PyVmT activation are poorly understood. The insulin-like growth factor I receptor (IGF-IR) and the insulin receptor (IR) are...
- The role of SPARC in the TRAMP model of prostate carcinogenesis and progression
[作者:Said, N; Frierson, HF; Chernauskas, D; Conaway, M; Motamed, K; Theodorescu, D,期刊:Oncogene, 页码:3487-3498 , 文章类型: Article,,卷期:2009年28-39]
- SPARC (Secreted Protein Acidic and Rich in Cysteine), is a matricellular glycoprotein that is produced by tumor and/or neighboring stroma. In human prostate cancer, SPARC immunoreactivity is highest in metastatic lesions...
- PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers
[作者:Klanrit, P; Taebunpakul, P; Flinterman, MB; Odell, EW; Riaz, MA; Melino, G; Salomoni, P; Mymryk, JS; Gaken, J; Farzaneh, F; Tavassoli, M,期刊:Oncogene, 页码:3499-3512 , 文章类型: Article,,卷期:2009年28-39]
- Epidermal growth factor receptor (EGFR) tyrosine kinase is commonly overexpressed in human cancers; however, the cellular mechanisms regulating EGFR expression remain unclear. p53, p63 and p73 are transcription factors r...
- 5q-myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics
[作者:Eisenmann, KM; Dykema, KJ; Matheson, SF; Kent, NF; DeWard, AD; West, RA; Tibes, R; Furge, KA; Alberts, AS,期刊:Oncogene, 页码:3429-3441 , 文章类型: Review,,卷期:2009年28-39]
- Complete loss or interstitial deletions of chromosome 5 are the most common karyotypic abnormality in myelodysplastic syndromes (MDSs). Isolated del(5q)/5q- MDS patients have a more favorable prognosis than those with ad...
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