- p53 responsive elements in human retrotransposons
[作者:Harris, CR; DeWan, A; Zupnick, A; Normart, R; Gabriel, A; Prives, C; Levine, AJ; Hoh, J,期刊:Oncogene, 页码:3857-3865 , 文章类型: Article,,卷期:2009年28-44]
- Long interspersed nuclear elements-1 (L1s) are highly repetitive DNA elements that are capable of altering the human genome through retrotransposition. To protect against L1 retroposition, the cell downregulates the expr...
- Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling
[作者:Ashley, N; Poulton, J,期刊:Oncogene, 页码:3880-3891 , 文章类型: Article,,卷期:2009年28-44]
- Many anticancer drugs, such as doxorubicin (DXR), intercalate into nuclear DNA of cancer cells, thereby inhibiting their growth. However, it is not well understood how such drugs interact with mitochondrial DNA (mtDNA). ...
- The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation
[作者:Shah, KM; Stewart, SE; Wei, W; Woodman, CBJ; O'Neil, JD; Dawson, CW; Young, LS,期刊:Oncogene, 页码:3903-3914 , 文章类型: Article,,卷期:2009年28-44]
- Although frequently expressed in Epstein-Barr virus (EBV)-positive malignancies, the role that latent membrane protein 2A and 2B (LMP2A and LMP2B) have in the oncogenic process remains obscure. Here we show a novel funct...
- The prolyl cis/trans isomerase cyclophilin 18 interacts with the tumor suppressor p53 and modifies its functions in cell cycle regulation and apoptosis
[作者:Baum, N; Schiene-Fischer, C; Frost, M; Schumann, M; Sabapathy, K; Ohlenschlager, O; Grosse, F; Schlott, B,期刊:Oncogene, 页码:3915-3925 , 文章类型: Article,,卷期:2009年28-44]
- The functional diversity of the tumor suppressor protein p53 is mainly regulated by protein interactions. In this study, we describe a new interaction with the peptidylprolyl cis/trans isomerase cyclophilin 18 (Cyp18). T...
- Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis
[作者:Seckinger, A; Meissner, T; Moreaux, J; Goldschmidt, H; Fuhler, GM; Benner, A; Hundemer, M; Reme, T; Shaughnessy, JD; Barlogie, B; Bertsch, U; Hillengass, J; Ho, AD; Pantesco, V; Jauch, A; De Vos, J; Rossi, JF; Mohler, T; Klein, B; Hose, D,期刊:Oncogene, 页码:3866-3879 , 文章类型: Article,,卷期:2009年28-44]
- Pathogenesis of multiple myeloma is associated with an aberrant expression of pro-proliferative, pro-angiogenic and bone-metabolism-modifying factors by malignant plasma cells. Given the frequently long time span from di...
- Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines
[作者:Leivonen, SK; Makela, R; Ostling, P; Kohonen, P; Haapa-Paananen, S; Kleivi, K; Enerly, E; Aakula, A; Hellstrom, K; Sahlberg, N; Kristensen, VN; Borresen-Dale, AL; Saviranta, P; Perala, M; Kallioniemi, O,期刊:Oncogene, 页码:3926-3936 , 文章类型: Article,,卷期:2009年28-44]
- Predicting the impact of microRNAs (miRNAs) on target proteins is challenging because of their different regulatory effects at the transcriptional and translational levels. In this study, we applied a novel protein lysat...
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