- Smad, but not MAPK, pathway mediates the expression of type I collagen in radiation induced fibrosis
[作者:Yano, H; Hamanaka, R; Nakamura, M; Sumiyoshi, H; Matsuo, N; Yoshioka, H,期刊:Biochemical and Biophysical Research Communications, 页码:457-463 , 文章类型: Article,,卷期:2012年418-3]
- Radiation induced fibrosis occurs following a therapeutic or accidental radiation exposure in normal tissues. Tissue fibrosis is the excessive accumulation of collagen and other extracellular matrix components. This stud...
- Proinsulin C-peptide interferes with insulin fibril formation
[作者:Landreh, M; Stukenborg, JB; Willander, H; Soder, O; Johansson, J; Jornvall, H,期刊:Biochemical and Biophysical Research Communications, 页码:489-493 , 文章类型: Article,,卷期:2012年418-3]
- Insulin aggregation can prevent rapid insulin uptake and cause localized amyloidosis in the treatment of type-1 diabetes. In this study, we investigated the effect of C-peptide, the 31-residue peptide cleaved from proins...
- The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis
[作者:Ogata, A; Endo, M; Aoi, J; Takahashi, O; Kadomatsu, T; Miyata, K; Tian, Z; Jinnin, M; Fukushima, S; Ihn, H; Oike, Y,期刊:Biochemical and Biophysical Research Communications, 页码:494-499 , 文章类型: Article,,卷期:2012年418-3]
- Dermatomyositis (DM) is an autoimmune disease marked by chronic inflammation of skin and muscle tissues and characterized clinically by proximal muscle weakness and skin eruption, including heliotrope rash, and Gottron's...
- Inhibition of RhoA but not ROCK induces chondrogenesis of chick limb mesenchymal cells
[作者:Kim, MJ; Kim, S; Kim, Y; Jin, EJ; Sonn, JK,期刊:Biochemical and Biophysical Research Communications, 页码:500-505 , 文章类型: Article,,卷期:2012年418-3]
- Cell shape change and cytoskeletal reorganization are known to be involved in the chondrogenesis. Negative role of RhoA, a cytoskeleton-regulating protein, and its downstream target, Rho-associated protein kinase (ROCK) ...
- Membrane topology of murine glycerol-3-phosphate acyltransferase 2
[作者:Nakagawa, T; Harada, N; Miyamoto, A; Kawanishi, Y; Yoshida, M; Shono, M; Mawatari, K; Takahashi, A; Sakaue, H; Nakaya, Y,期刊:Biochemical and Biophysical Research Communications, 页码:506-511 , 文章类型: Article,,卷期:2012年418-3]
- Glycerol-3-phosphate acyltransferase (GPAT) is a rate-limiting enzyme in mammalian triacylglycerol biosynthesis. GPAT is a target for the treatment of metabolic disorders associated with high lipid accumulation. Although...
- SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components
[作者:Jung, I; Sohn, DH; Choi, J; Kim, JM; Jeon, S; Seol, JH; Seong, RH,期刊:Biochemical and Biophysical Research Communications, 页码:512-517 , 文章类型: Article,,卷期:2012年418-3]
- The murine SWI/SNF-like BAF complex is an ATP-dependent chromatin remodeling complex that functions as a transcriptional regulator in cell proliferation, differentiation and development. The SWI/SNF-like BAF complex cons...
- Structural analysis and serological test of arginine periplasmic binding protein 2 from Chlamydophila pneumoniae
[作者:Park, SH; Chang, JE; Hawkes, HJK; Kang, YH; Hwang, KY,期刊:Biochemical and Biophysical Research Communications, 页码:518-524 , 文章类型: Article,,卷期:2012年418-3]
- The 'art' genes encode specific arginine uptake proteins, and are repressed by the repressible promoters of ArgR, affecting transcription of artJ [1,2]. Cpb0502, the arginine-binding periplasmic protein 2 precursor from ...
- High copies of SUM1 enhance the stability of wild-type microtubules against adverse conditions in Saccharomyces cerevisiae
[作者:Haldar, S; Sarkar, S; Singh, V; Sinha, P,期刊:Biochemical and Biophysical Research Communications, 页码:525-530 , 文章类型: Article,,卷期:2012年418-3]
- The budding yeast transcriptional repressor Sum1p binds to several promoters and recruits Hst1p, an NAD(+)-dependent histone deacetylase, at these promoters with the help of another protein Rfm1p. Hst1p causes repression...
- Sorafenib down-regulates c-IAP expression post-transcriptionally in hepatic carcinoma cells to suppress apoptosis
[作者:Li, XF; Gong, RY; Wang, M; Yan, ZL; Yuan, B; Wang, K; Shi, LH,期刊:Biochemical and Biophysical Research Communications, 页码:531-536 , 文章类型: Article,,卷期:2012年418-3]
- Hepatocellular carcinoma (HCC) is one of leading causes of cancer-related death with a heterogeneous patient demographic and divergent pathogenic pathways. Sorafenib is the first effective drug approved for the treatment...
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