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  • Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast Cancer
    [作者:Baselga, J; Campone, M; Piccart, M; Burris, HA; Rugo, HS; Sahmoud, T; Noguchi, S; Gnant, M; Pritchard, KI; Lebrun, F; Beck, JT; Ito, Y; Yardley, D; Deleu, I; Perez, A; Bachelot, T; Vittori, L; Xu, ZY; Mukhopadhyay, P; Lebwohl, D; Hortobagyi, GN,期刊:New England Journal of Medicine, 页码:520-529 , 文章类型: Article,,卷期:2012年366-6]
  • Background Resistance to endocrine therapy in breast cancer is associated with activation of the mammalian target of rapamycin (mTOR) intracellular signaling pathway. In early studies, the mTOR inhibitor everolimus added...
  • Antenatal Thyroid Screening and Childhood Cognitive Function
    [作者:Lazarus, JH; Bestwick, JP; Channon, S; Paradice, R; Maina, A; Rees, R; Chiusano, E; John, R; Guaraldo, V; George, LM; Perona, M; Dall'Amico, D; Parkes, AB; Joomun, M; Wald, NJ,期刊:New England Journal of Medicine, 页码:493-501 , 文章类型: Article,,卷期:2012年366-6]
  • Background Children born to women with low thyroid hormone levels have been reported to have decreased cognitive function. Methods We conducted a randomized trial in which pregnant women at a gestation of 15 weeks 6 days...