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  • Clonal Architecture of Secondary Acute Myeloid Leukemia
    [作者:Walter, MJ; Shen, D; Ding, L; Shao, J; Koboldt, DC; Chen, K; Larson, DE; McLellan, MD; Dooling, D; Abbott, R; Fulton, R; Magrini, V; Schmidt, H; Kalicki-Veizer, J; O'Laughlin, M; Fan, X; Grillot, M; Witowski, S; Heath, S; Frater, JL; Eades, W; Tomasson, M; Westervelt, P; DiPersio, JF; Link, DC; Mardis, ER; Ley, TJ; Wilson, RK; Graubert, TA,期刊:New England Journal of Medicine, 页码:1090-1098 , 文章类型: Article,,卷期:2012年366-12]
  • BACKGROUND The myelodysplastic syndromes are a group of hematologic disorders that often evolve into secondary acute myeloid leukemia (AML). The genetic changes that underlie progression from the myelodysplastic syndrome...
  • Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
    [作者:Patel, JP; Gonen, M; Figueroa, ME; Fernandez, H; Sun, ZX; Racevskis, J; Van Vlierberghe, P; Dolgalev, I; Thomas, S; Aminova, O; Huberman, K; Cheng, J; Viale, A; Socci, ND; Heguy, A; Cherry, A; Vance, G; Higgins, RR; Ketterling, RP; Gallagher, RE; Litzow, M; van den Brink, MRM; Lazarus, HM; Rowe, JM; Luger, S; Ferrando, A; Paietta, E; Tallman, MS; Melnick, A; Abdel-Wahab, O; Levine, RL,期刊:New England Journal of Medicine, 页码:1079-1089 , 文章类型: Article,,卷期:2012年366-12]
  • BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated in...