- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
[作者：Gerlinger, M; Rowan, AJ; Horswell, S; Larkin, J; Endesfelder, D; Gronroos, E; Martinez, P; Matthews, N; Stewart, A; Tarpey, P; Varela, I; Phillimore, B; Begum, S; McDonald, NQ; Butler, A; Jones, D; Raine, K; Latimer, C; Santos, CR; Nohadani, M; Eklund, AC; Spencer-Dene, B; Clark, G; Pickering, L; Stamp, G; Gore, M; Szallasi, Z; Downward, J; Futreal, PA; Swanton, C,期刊：New England Journal of Medicine, 页码：883-892 , 文章类型： Article，,卷期：2012年366-10]
- BACKGROUND Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS To examine intratumor heterogenei...
- A 12-Month Phase 3 Study of Pasireotide in Cushing's Disease
[作者：Colao, A; Petersenn, S; Newell-Price, J; Findling, JW; Gu, F; Maldonado, M; Schoenherr, U; Mills, D; Salgado, LR; Biller, BMK,期刊：New England Journal of Medicine, 页码：914-924 , 文章类型： Article，,卷期：2012年366-10]
- BACKGROUND Cushing's disease is associated with high morbidity and mortality. Pasireotide, a potential therapy, has a unique, broad somatostatin-receptor-binding profile, with high binding affinity for somatostatin-recep...
- Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease
[作者：Howard, R; McShane, R; Lindesay, J; Ritchie, C; Baldwin, A; Barber, R; Burns, A; Dening, T; Findlay, D; Holmes, C; Hughes, A; Jacoby, R; Jones, R; Jones, R; McKeith, I; Macharouthu, A; O'Brien, J; Passmore, P; Sheehan, B; Juszczak, E; Katona, C; Hills, R; Knapp, M; Ballard, C; Brown, R; Banerjee, S; Onions, C; Griffin, M; Adams, J; Gray, R; Johnson, T; Bentham, P; Phillips, P,期刊：New England Journal of Medicine, 页码：893-903 , 文章类型： Article，,卷期：2012年366-10]
- BACKGROUND Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer's disease. It is not known whether treatment benefits continue after the progression to mode...
- Enzyme-Replacement Therapy in Life-Threatening Hypophosphatasia
[作者：Whyte, MP; Greenberg, CR; Salman, NJ; Bober, MB; McAlister, WH; Wenkert, D; Van Sickle, BJ; Simmons, JH; Edgar, TS; Bauer, ML; Hamdan, MA; Bishop, N; Lutz, RE; McGinn, M; Craig, S; Moore, JN; Taylor, JW; Cleveland, RH; Cranley, WR; Lim, R; Thacher, TD; Mayhew, JE; Downs, M; Millan, JL; Skrinar, AM; Crine, P; Landy, H,期刊：New England Journal of Medicine, 页码：904-913 , 文章类型： Article，,卷期：2012年366-10]
- BACKGROUND Hypophosphatasia results from mutations in the gene for the tissue-nonspecific isozyme of alkaline phosphatase (TNSALP). Inorganic pyrophosphate accumulates extracellularly, leading to rickets or osteomalacia....
- Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma
[作者：Postow, MA; Callahan, MK; Barker, CA; Yamada, Y; Yuan, JD; Kitano, S; Mu, ZY; Rasalan, T; Adamow, M; Ritter, E; Sedrak, C; Jungbluth, AA; Chua, R; Yang, AS; Roman, RA; Rosner, S; Benson, B; Allison, JP; Lesokhin, AM; Gnjatic, S; Wolchok, JD,期刊：New England Journal of Medicine, 页码：925-931 , 文章类型： Article，,卷期：2012年366-10]
- The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immu...
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